Table 1 The Solute Carrier 15 (proton oligopeptide cotransporter) family members in human (Homo sapiens) and zebrafish (Danio rerio)
Human | Zebrafish | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
From http://zfin.org | |||||||||||
SLC name | Protein name | Aliases | Transport type | Substrates | Tissue and cellular expression | Substrates | slc name | EST profile | Tissue and cellular expression | Stage range | References |
SLC15A1 | PEPT1 | Oligopeptide transporter 1, H+-peptide transporter 1 | C/H+ | Di- and tripeptides, protons, β-lactam antibiotics | Small intestine, kidney, pancreas, bile duct, liver | Endogenous substrates: 5-aminolevulinic acid, dipeptides, protons, tripeptides. Other substrates: fMet-Leu-Phe, muramyl dipeptide, D-Ala-Lys-AMCA, β-Ala-Lys-AMCA, His-Leu-lopinavir, alafosfalin. | slc15a1a (Chr 9) | – | Details in this study | Details in this study | This study |
slc15a1b (Chr 6) | Developmental stage|larval > adult Adult|intestine | Digestive system, gut, intestinal bulb, intestinal bulb enterocyte, intestinal epithelium, liver, muscle, squamous epithelial cell, whole organism | Prim-5 to adult | ||||||||
SLC15A2 | PEPT2 | Oligopeptide transporter 2, H+-peptide transporter 2 | C/H+ | Di- and tripeptides, protons, β-lactam antibiotics | Apical surface of epithelial cells from kidney and choroid plexus; neurons, astrocytes (neonates), lung, mammary gland, spleen, enteric nervous system | Endogenous substrates: 5-aminolevulinic acid, dipeptides, protons, tripeptides. Other substrates: muramyl dipeptide, D-Ala-Lys-AMCA, β-Ala-Lys-AMCA, alafosfalin, γ-iE-DAP. | slc15a2 (Chr 9) | Developmental stage|adult Adult|intestine >> kidney > reproductive system | Brain, eye, gill, gut, kidney, musculature system, otic vesicle, semicircular canal, ventricular system, whole organism | 26+ somites to day 6; days 30–44; adult | |
SLC15A3 | PHT2 | Peptide/histidine transporter 2, PTR3 | C/H+ | Di- and tripeptides, protons, β-lactam antibiotics | Lung, spleen, thymus, intestine (faintly in brain, liver, adrenal gland, heart) | Endogenous substrates: L-histidine, dipeptides, protons, tripeptides. Other substrates: muramyl dipeptide, MDP-rhodamine, Tri-DAP | n.p. | n.p. | n.p. | n.p. | n.p. |
SLC15A4 | PHT1 | Peptide/histidine transporter 1, PTR4 | C/H+ | Di- and tripeptides, protons, β-lactam antibiotics | Brain, eye, intestine (faintly in lung and spleen) | Endogenous substrates: L-histidine, carnosine Other substrates: valacyclovir, muramyl dipeptide, His-Leu-lopinavir, glycyl-sarcosine, MDP-rhodamine, Tri-DAP, C12-iE-DAP | slc15a4 (Chr 8) | Developmental stage|adult Adult|brain ≈ reproductive system ≥ fin | Epidermis, eye, immature eye, midbrain, periderm, ventricular zone, yolk syncytial layer | 50%-epiboly to Long-pec | [24] |