Table 3 Frequency of CYP11A1, CYP24A1, CYP27A1 and CYP2R1 variants in EUR, EAS and AFR groups

 rs11632698

60 (2357)

0.57 (0.54–0.60)

0.20^a (0.17–0.23)

0.20^a (0.17–0.23)

3.37e–25

0.86

EUR ≠ AFR and EAS

 rs2073475

60 (2352)

0.16 (0.13–0.16)

0.45 (0.42–0.48)

0.58 (0.55–0.61)

1.89e–27

0.88

EUR ≠ AFR ≠ EAS

 rs3787557

60 (2349)

0.13 (0.11–0.16)

0.27 (0.24–0.29)

0.00 (− 0.02–0.03)

3.55e–22

0.82

EUR ≠ AFR ≠ EAS

 rs927650

60 (2380)

0.47 (0.44–0.49)

0.27 (0.25–0.30)

0.18 (0.16–0.21)

4.52e–22

0.82

EUR ≠ AFR ≠ EAS

 rs912505

60 (2356)

0.21 (0.18–0.25)

0.62 (0.59–0.65)

0.45 (0.41–0.48)

1.04e–23

0.84

EUR ≠ AFR ≠ EAS

 rs2762929

69 (2356)

0.58 (0.55–0.61)

0.30^a (0.26–0.33)

0.25^a (0.22–0.29)

1.40e–20

0.79

EUR ≠ AFR and EAS

 rs4809956

45 (1854)

0.81 (0.77–0.86)

0.43^a (0.39–0.47)

0.40^a (0.36–0.44)

2.23e–18

0.85

EUR ≠ AFR and EAS

 rs7568196

60 (2355)

0.40 (0.35-0.44)

0.06^a (0.02–0.11)

0.18^a (0.13–0.22)

3.20e–14

0.65

EUR ≠ AFR and EAS

 rs4674338

60 (2301)

0.58 (0.56–0.61)

0.93 (0.91–0.96)

0.74 (0.71–0.76)

1.94e–27

0.88

EUR ≠ AFR ≠ EAS

 rs13013510

60 (2356)

0.51 (0.47–0.54)

0.19 (0.15–0.22)

0.65 (0.62–0.69)

5.91e–26

0.87

EUR ≠ AFR ≠ EAS

 rs691414

60 (2356)

1.00^a (0.98–1.02)

1.00^a (0.98–1.02)

0.78 (0.76–0.79)

1.31e–28

0.89

AFR ≠ EUR and EAS

 rs692290

60 (2356)

1.00^a (0.98–1.02)

1.00^a (0.98–1.02)

0.60 (0.58–0.62)

2.20e–42

0.96

AFR ≠ EUR and EAS

 rs16930625

60 (2356)

0.08^a (0.06–0.11)

0.12^a,b (0.10–0.15)

0.19^b (0.17–0.21)

1.03e–07

0.41

AFR ≠ EUR

 rs11023374

60 (2342)

0.28 (0.26–0.31)

0.09^a (0.06–0.11)

0.02^a (− 0.01–0.04)

1.35e–20

0.79

EUR ≠ AFR and EAS