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Table 3 Frequency of CYP11A1, CYP24A1, CYP27A1 and CYP2R1 variants in EUR, EAS and AFR groups

From: Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations

 Sample sets (subjects)Mean allelic frequency (95% CI)*  Distribution pattern#
 EUREASAFRpr2
CYP11A1
 rs1163269860 (2357)0.57 (0.54–0.60)0.20a (0.17–0.23)0.20a (0.17–0.23)3.37e–250.86EUR ≠ AFR and EAS
 rs207347560 (2352)0.16 (0.13–0.16)0.45 (0.42–0.48)0.58 (0.55–0.61)1.89e–270.88EUR ≠ AFR ≠ EAS
CYP24A1
 rs378755760 (2349)0.13 (0.11–0.16)0.27 (0.24–0.29)0.00 (− 0.02–0.03)3.55e–220.82EUR ≠ AFR ≠ EAS
 rs92765060 (2380)0.47 (0.44–0.49)0.27 (0.25–0.30)0.18 (0.16–0.21)4.52e–220.82EUR ≠ AFR ≠ EAS
 rs91250560 (2356)0.21 (0.18–0.25)0.62 (0.59–0.65)0.45 (0.41–0.48)1.04e–230.84EUR ≠ AFR ≠ EAS
 rs276292969 (2356)0.58 (0.55–0.61)0.30a (0.26–0.33)0.25a (0.22–0.29)1.40e–200.79EUR ≠ AFR and EAS
 rs480995645 (1854)0.81 (0.77–0.86)0.43a (0.39–0.47)0.40a (0.36–0.44)2.23e–180.85EUR ≠ AFR and EAS
CYP27A1
 rs756819660 (2355)0.40 (0.35-0.44)0.06a (0.02–0.11)0.18a (0.13–0.22)3.20e–140.65EUR ≠ AFR and EAS
 rs467433860 (2301)0.58 (0.56–0.61)0.93 (0.91–0.96)0.74 (0.71–0.76)1.94e–270.88EUR ≠ AFR ≠ EAS
 rs1301351060 (2356)0.51 (0.47–0.54)0.19 (0.15–0.22)0.65 (0.62–0.69)5.91e–260.87EUR ≠ AFR ≠ EAS
 rs69141460 (2356)1.00a (0.98–1.02)1.00a (0.98–1.02)0.78 (0.76–0.79)1.31e–280.89AFR ≠ EUR and EAS
 rs69229060 (2356)1.00a (0.98–1.02)1.00a (0.98–1.02)0.60 (0.58–0.62)2.20e–420.96AFR ≠ EUR and EAS
CYP2R1
 rs1693062560 (2356)0.08a (0.06–0.11)0.12a,b (0.10–0.15)0.19b (0.17–0.21)1.03e–070.41AFR ≠ EUR
 rs1102337460 (2342)0.28 (0.26–0.31)0.09a (0.06–0.11)0.02a (− 0.01–0.04)1.35e–200.79EUR ≠ AFR and EAS
  1. *Frequency values notated with the same letter are not significantly different from each other
  2. #EUR ≠ AFR ≠ EAS; allelic frequency differed between all geographic groups, EUR ≠ AFR and EAS; allelic frequency differed between EUR and both AFR and EAS, AFR ≠ EUR and EAS; allelic frequency differed between AFR and both EUR and EAS, allelic frequency differed between AFR and EUR.