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Table 1 Comparison general characteristics, clinical, and laboratory parameters of participants according to MC4R rs17782313 genotypes

From: Melanocortin-4 receptor (MC4R) rs17782313 polymorphism interacts with Dietary Approach to Stop Hypertension (DASH) and Mediterranean Dietary Score (MDS) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals

 

Women

Men

 

TT

TC

CC

P*

 

TT

TC

CC

P*

Age (year)

38.46 (8.95)

39.07 (8.32)

36.31 (8.54)

0.628

39.21 (6.75)

37.26 (6.07)

40.44 (3.64)

0.527

WC

103.06 (10.43)

105.33 (9.31)

101.14 (7.14)

0.439

113.54 (5.89)

113.57 (7.45)

112.56 (5.20)

0.651

BMI (kg/m2)

35.02 (4.25)

35.27 (3.41)

34.99 (3.80)

0.990

33.90 (2.45)

33.55 (2.85)

33.64 (2.53)

0.622

Physical activity level (%)

   

0.129

   

0.778

 Low

33.3

42.9

23.8

 

51.7

34.5

13.8

 

 Moderate

26.7

46.6

26.7

 

44.4

44.4

11.2

 

 High

66.7

20.0

13.3

 

54.6

22.7

22.7

 

Marital status (%)

   

0.883

   

0.827

 Married

36.7

36.7

22.6

 

49.1

35.6

15.3

 

 Single

40.0

40.0

20.0

 

60.0

20.0

20.0

 

SES (%)

        

 Low

0

50.0

50.0

0.024

0

0

0

0.904

 Middle

37.0

38.9

24.1

 

59.1

18.2

22.7

 

 High

57.2

35.7

7.1

 

46.8

40.4

12.8

 

Depressing (%)

   

0.503

   

0.439

 Normal

45.8

37.5

16.7

 

48.7

30.8

20.5

 

 Mild

18.2

54.5

27.3

 

45.5

54.5

0.0

 

 Moderate

33.3

23.8

42.9

 

53.8

30.8

15.4

 

 Severe

42.8

28.6

28.6

 

66.7

0.0

33.3

 

 Extremely severe

22.2

66.7

11.1

 

66.7

33.3

0.0

 

Anxiety (%)

   

0.550

   

0.909

 Normal

40.0

45.0

15.0

 

48.4

35.5

16.1

 

 Mild

50.0

37.5

12.5

 

40.0

40.0

20.0

 

 Moderate

33.3

38.9

27.8

 

61.1

33.3

5.6

 

 Severe

37.5

25.0

37.5

 

50.0

25.0

25.0

 

 Extremely severe

38.9

38.9

22.2

 

42.8

28.6

28.6

 

Stress (%)

   

0.275

   

0.602

 Normal

34.8

43.5

21.7

 

50.0

35.3

14.7

 

 Mild

30.8

30.8

38.4

 

41.7

33.3

25.0

 

 Moderate

42.9

38.1

19.0

 

50.0

35.7

14.3

 

 Severe

38.5

46.1

15.4

 

80.0

0.0

20.0

 

 Extremely severe

100.0

0.0

0.0

 

50.0

50.0

0.0

 

Appetite

32.39 (9.49)

31.89 (6.80)

33.75 (7.62)

0.783

34.21 (10.75)

34.70 (10.00)

35.78 (7.93)

0.880

LDL-C (mg/dl)

126.9 (29.6)

118.56 (31.06)

108.91 (28.09)

0.161

121.48 (25.94)

118.30 (30.01)

117.58 (22.48)

0.471

HDL (mg/dl)

48.46 (10.27)

46.37 (10.19)

49.44 (6.46)

0.549

40.91 (6.79)

43.35 (9.22)

45.00 (10.46)

0.388

Cholesterol (mg/dl)

197.71 (33.88)

185.74 (35.45)

177.75 (28.62)

0.146

188.88 (28.64)

187.78 (31.20)

193.56 (28.58)

0.918

TG (mg/dl)

98.5 (77.75, 141.00)

93.00 (76.00, 125.00)

98.50 (73.25, 109.75)

0.638

120.00 (78.00, 168.50)

121.00 (90.00, 164.00)

123.00 (93.00, 176.50)

0.869

AIP

− 0.02 (0.24)

− 0.03 (0.23)

− .09 (0.17)

0.631

0.11 (0.26)

0.09 (0.25)

0.12 (0.29)

0.907

Glucose (mg/dl)

92.00 (85.25, 95.00)

91.00 (81.00, 101.00)

90.00 (85.25, 94.00)

0.834

93.00 (87.00, 101.50)

90.00 (83.00, 97.00)

101.00 (89.00, 159.50)

0.040

Insulin, U/ml

13.55 (9.28, 24.10)

19.60 (9.70, 27.30)

13.75 (9.00, 16.23)

0.306

11.40 (8.35, 17.70)

10.90 (8.40, 19.50)

11.00 (9.75, 25.80)

0.507

HOMA-IR

3.17 (2.00, 5.56)

4.82 (2.01, 6.58)

3.15 (2.09, 3.86)

0.409

2.70 (1.76, 4.06)

2.61 (1.87, 5.04)

4.16 (2.75, 6.99)

0.077

QUICKI

0.32 (0.03)

0.32 (0.04)

0.33 (0.03)

0.466

0.33 (0.03)

0.33 (0.03)

0.31 (0.03)

0.126

SBP (mmHg)

111.86 (14.48)

117.26 (16.85)

111.19 (14.40)

0.404

116.67 (11.43)

118.70 (15.83)

116.67 (14.14)

0.816

DBP (mmHg)

76.50 (10.11)

79.15 (14.55)

75.50 (11.68)

0.644

76.51 (10.86)

78.26 (10.93)

75.56 (12.10)

0.584

α-MSH (ng/l)

2.16 (2.12–2.20)

2.26 (2.17–2.36)

2.26 (2.11–2.41)

0.153

2.29 (2.20–2.37)

2.39 (2.25–2.52)

2.18 (2.09–2.27)

0.105

AgRP (pg/ml)

1.33 (1.29–1.37)

1.44 (1.36–1.51)

1.41 (1.29–1.53)

0.082

1.49 (1.42–1.57)

1.57 (1.46–1.68)

1.33 (1.25–1.41)

0.025

  1. Data are presented as mean (SD) or median (25 and 75 percentiles)
  2. BMI body mass index, WC waist circumference, SES socio-economic status, HOMA-IR homeostasis model assessment of insulin resistance, LDL-C low density lipoprotein cholesterol, HDL high-density lipoprotein, SBP systolic blood pressure, DBP diastolic blood pressure, TG triglyceride, QUICKI quantitative insulin sensitivity check index, AgRP agouti-related protein, α-MSH alpha melanocyte stimulating hormone, AIP atherogenic index of plasma
  3. *Analysis of variance for continuous variables and χ2 test for categorical variables