Testosterone deficiency caused by castration increases adiposity in male rats in a tissue-specific and diet-dependent manner

Table 2 The serum parameters of sham-operated (control) and castrated-male rats fed either normal diet or high-fat diet at 8-h fasted state

Item	Normal diet		High-fat diet		P
	Control	Castration	Control	Castration	Castration	Diet	Interaction
Testosterone, pg/mL	8.30 ± 1.04^a	2.39 ± 0.13^b	11.0 ± 1.57^a	1.73 ± 0.39^b	< 0.001	NS	NS
Free fatty acid, μEq/L	439 ± 43.3^b	649 ± 41.3^a	418 ± 31.7^b	533 ± 25.4^b	< 0.001	NS	NS
Insulin, ng/mL	4.27 ± 0.38^a	4.25 ± 0.23^a	2.43 ± 0.34^b	1.38 ± 0.31^b	NS	< 0.001	NS
Total cholesterol, mg/dL	78.5 ± 2.87^b	105 ± 3.74^a	97.5 ± 4.50^a	112 ± 6.17^a	< 0.001	0.02	NS
LDL cholesterol, mg/dL	7.1 ± 0.56^b	10.2 ± 1.57^a	15.7 ± 1.30^a	13.2 ± 0.69^a	NS	< 0.001	0.04
HDL cholesterol, mg/dL	69.4 ± 2.76^b	95.1 ± 4.59^a	83.3 ± 5.03^a	95.7 ± 5.00^a	< 0.001	NS	NS
Triglyceride mg/dL	100 ± 12.3	93.7 ± 8.30	81.7 ± 8.35	78.1 ± 7.24	NS	NS	NS
Glucose, mg/dL	179 ± 17.1^b	237 ± 10.9^a	190 ± 16.2^b	215 ± 10.1^ab	0.01	NS	NS

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