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Table 2 The serum parameters of sham-operated (control) and castrated-male rats fed either normal diet or high-fat diet at 8-h fasted state

From: Testosterone deficiency caused by castration increases adiposity in male rats in a tissue-specific and diet-dependent manner

Item Normal diet   High-fat diet P   
  Control Castration Control Castration Castration Diet Interaction
Testosterone, pg/mL 8.30 ± 1.04a 2.39 ± 0.13b 11.0 ± 1.57a 1.73 ± 0.39b < 0.001 NS NS
Free fatty acid, μEq/L 439 ± 43.3b 649 ± 41.3a 418 ± 31.7b 533 ± 25.4b < 0.001 NS NS
Insulin, ng/mL 4.27 ± 0.38a 4.25 ± 0.23a 2.43 ± 0.34b 1.38 ± 0.31b NS < 0.001 NS
Total cholesterol, mg/dL 78.5 ± 2.87b 105 ± 3.74a 97.5 ± 4.50a 112 ± 6.17a < 0.001 0.02 NS
LDL cholesterol, mg/dL 7.1 ± 0.56b 10.2 ± 1.57a 15.7 ± 1.30a 13.2 ± 0.69a NS < 0.001 0.04
HDL cholesterol, mg/dL 69.4 ± 2.76b 95.1 ± 4.59a 83.3 ± 5.03a 95.7 ± 5.00a < 0.001 NS NS
Triglyceride mg/dL 100 ± 12.3 93.7 ± 8.30 81.7 ± 8.35 78.1 ± 7.24 NS NS NS
Glucose, mg/dL 179 ± 17.1b 237 ± 10.9a 190 ± 16.2b 215 ± 10.1ab 0.01 NS NS
  1. Mean ± SE (n = 7–8)
  2. NS not significant
  3. a-bMeans in row with different superscripts differ (P < 0.05)