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Table 3 Associations between serum folate level and risk of EPL and ESCC

From: Moderately high folate level may offset the effects of aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and precancerous lesions

Serum folate (μg/L)

Control

EPL

ESCC

n (%)

n (%)

OR (95% CI)a

p value

n (%)

OR (95% CI)a

p value

Q1 (< 24.43)

50 (25.0)

80 (40.0)

1.00 (referent)

 

90 (45.0)

1.00 (referent)

 

Q2 (24.43–29.14)

50 (25.0)

68 (34.0)

0.73 (0.41–1.30)

0.290

55 (27.5)

0.67 (0.39–1.152)

0.147

Q3 (29.14–36.24)

50 (25.0)

24 (12.0)

0.32 (0.16–0.62)

0.001

44 (22.0)

0.51 (0.29–0.89)

0.017

Q4 (> 36.24)

50 (25.0)

28 (14.0)

0.26 (0.13–0.54)

< 0.001

11 (5.5)

0.15 (0.07–0.32)

< 0.001

  1. aAdjusted for gender, age, tobacco smoking, and alcohol drinking