Table 4 Association between serum folate level with p16 methylation status and the risk of EPL and ESCC

From: Moderately high folate level may offset the effects of aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and precancerous lesions

Serum folate (μg/L)	EPL [OR (95% CI)^a, p for interaction]		ESCC [OR (95% CI)^a, p for interaction]
Serum folate (μg/L)	p16U	p16M	p16U	p16M
Q1 (< 24.43)	1.00 (reference)	1.63 (0.79–3.35), 0.183	1.00 (reference)	2.96 (1.45–6.05), 0.003
Q2 (24.43–29.14)	0.82 (0.42–1.59), 0.559	1.60 (0.75–3.42), 0.226	0.57 (0.27–1.20), 0.137	2.12 (0.98–4.58), 0.056
Q3 (29.14–36.24)	0.41 (0.19–0.87), 0.021	0.27 (0.10–0.72), 0.009	0.52 (0.24–1.11), 0.090	1.31 (0.61–2.80), 0.489
Q4 (> 36.24)	0.35 (0.16–0.76), 0.008	0.62 (0.25–1.51), 0.294	0.15 (0.05–0.43), < 0.001	0.39 (0.13–1.13), 0.082

U unmethylated, M methylated
^aAdjusted for gender, age, tobacco smoking, and alcohol drinking

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