Table 6 Association between foods rich in folate with p16 methylation status and the risk of EPL and ESCC
Food intake frequency | EPL [OR (95% CI)a, p for interaction] | ESCC [OR (95% CI)a, p for interaction] | ||||||
|---|---|---|---|---|---|---|---|---|
p16U | p value | p16M | p value | p16U | p value | p16M | p value | |
Spinach | ||||||||
 Never | 1.00 (reference) | - | 0.80 (0.16–4.12) | 0.790 | 1.00 (reference) | - | 2.80 (0.78–10.02) | 0.113 |
 Less than once per week | 1.20 (0.41–3.53) | 0.740 | 1.52 (0.50–4.63) | 0.459 | 0.34 (0.13–0.93) | 0.035 | 0.76 (0.28–2.07) | 0.592 |
 Once per week or more | 0.84 (0.29–2.41) | 0.749 | 1.23 (0.41–3.64) | 0.714 | 0.29 (0.11–0.75) | 0.011 | 1.02 (0.39–2.63) | 0.974 |
Chinese cabbage | ||||||||
 Never | 1.00 (reference) | - | 1.45 (0.92–2.29) | 0.110 | 1.00 (reference) | - | 3.27 (2.01–5.30) | < 0.001 |
 Less than once per week | 0.78 (0.25–2.42) | 0.240 | 0.91 (0.22–3.77) | 0.901 | 2.62 (0.96–7.19) | 0.062 | 5.42 (1.68–17.51) | 0.005 |
 Once per week or more | 0.22 (0.10–0.47) | <0.001 | 0.43 (0.17–1.10) | 0.077 | 0.48 (0.23–1.03) | 0.059 | 1.44 (0.64–3.28) | 0.379 |
Livers | ||||||||
 Never | 1.00 (reference) | - | 1.58 (1.03–2.43) | 0.038 | 1.00 (reference) | - | 3.12 (1.99–4.87) | < 0.001 |
 Less than once per week | 0.36 (0.15–0.83) | 0.017 | 0.71 (0.12–4.34) | 0.710 | 0.82 (0.38–1.76) | 0.609 | 6.01 (1.61–22.41) | 0.008 |
 Once per week or more | 1.06 (0.30–3.79) | 0.924 | 0.27 (0.03–2.42) | 0.240 | 0.33 (0.04–2.87) | 0.314 | 0.41 (0.05–3.75) | 0.430 |
Beans | ||||||||
 Never | 1.00 (reference) | - | 0.76 (0.38–1.53) | 0.445 | 1.00 (reference) | - | 2.58 (1.26–5.32) | 0.010 |
 Less than once per week | 1.14 (0.80–2.24) | 0.712 | 1.99 (0.80–4.95) | 0.137 | 1.22 (0.55–2.69) | 0.626 | 3.79 (1.45–9.87) | 0.006 |
 Once per week or more | 0.47 (0.24–0.93) | 0.029 | 1.25 (0.59–2.63) | 0.566 | 0.83 (0.39–1.75) | 0.619 | 3.59 (1.65–7.82) | 0.001 |