Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

Liao, Jun Long; Qin, Qiang; Zhou, Yong Sheng; Ma, Ru Ping; Zhou, He Chao; Gu, Mao Rong; Feng, Yun Ping; Wang, Bo Yuan; Yang, Ling

doi:10.1186/s12263-020-00679-9

Table 3 The distribution of VDR BsmI genotypes for postmenopausal osteoporosis and controls

From: Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

BsmI rs1544410 (G > A)	Publication year	Ethnicity	Osteoporosis			Control			p^a
BsmI rs1544410 (G > A)	Publication year	Ethnicity	BB	Bb	bb	BB	Bb	bb	p^a
Marozik et al. [19]	2018	Caucasian	53	64	32	35	73	64	0.098
Ahmad et al. [20]	2018	Caucasian	54	137	63	54	152	48	0.002
Moran et al. [21]	2015	Caucasian	18	65	67	3	19	8	0.097
Marozik et al. [22]	2013	Caucasian	12	31	11	11	26	40	0.061
Gonzalez et al. [23]	2013	Caucasian	54	28	6	46	38	4	0.267
Efesoy et al. [24]	2011	Caucasian	5	23	12	5	15	10	0.876
Tanriover et al. [25]	2010	Caucasian	15	19	16	19	7	24	< 0.001
Mansour et al. [26]	2010	Caucasian	27	15	8	1	2	17	0.050
Musumeci et al. [27]	2009	Caucasian	30	55	15	13	60	27	0.025
Mencej et al. [28]	2009	Caucasian	103	110	27	88	100	40	0.215
Seremak et al. [29]	2009	Caucasian	27	66	70	10	27	26	0.506
Perez et al. [30]	2008	Caucasian	17	35	12	20	32	16	0.647
Uysal et al. [31]	2008	Caucasian	18	48	34	24	78	44	0.283
Quevedo et al. [32]	2008	Caucasian	11	46	10	9	37	13	0.050
Wengreen et al. [33]	2006	Caucasian	154	393	272	140	376	338	0.043
Garnero et al. [34]	2005	Caucasian	25	62	33	65	224	180	0.724
Mitra et al. [35]	2006	Caucasian	51	46	22	19	38	40	0.080
Duman et al. [36]	2004	Caucasian	18	54	3	17	42	7	0.014
Douroudis et al. [37]	2003	Caucasian	3	12	20	10	29	5	0.026
Lisker et al. [38]	2003	Caucasian	15	17	34	13	38	6	0.008
Borjas et al. [39]	2003	Caucasian	28	20	6	11	36	8	0.020
Zajickova et al. [40]	2002	Caucasian	21	24	20	10	13	10	0.223
Pollak et al. [41]	2001	Caucasian	13	38	24	16	67	60	0.675
Valimaki et al. [42]	2001	Caucasian	44	175	153	20	55	36	0.899
Aerssens et al. [43]	2000	Caucasian	26	60	49	52	125	62	0.459
Garrofe et al. [44]	2000	Caucasian	9	49	17	10	22	19	0.434
Gomez et al. [45]	1999	Caucasian	7	20	10	20	51	51	0.241
Gennari et al. [46]	1998	Caucasian	40	92	28	11	76	57	0.035
Vandevyver et al. [55]	1997	Caucasian	12	50	24	127	368	203	0.076
Houston et al. [56]	1996	Caucasian	8	19	17	9	19	16	0.450
Berg et al. [11]	1996	Caucasian	4	8	7	8	11	11	0.156
Melhus et al. [1]	1994	Caucasian	14	29	27	7	35	34	0.637
Techapatiphandee et al. [12]	2018	Asian	85	19	1	103	25	4	0.123
Zhang et al. [13]	2011	Asian	9	25	86	16	36	8	0.086
Zhu et al. [47]	2004	Asian	6	26	8	7	105	46	< 0.001
Chen et al. [48]	2003	Asian	0	7	33	0	3	18	0.724
Leng et al. [49]	2002	Asian	0	11	11	7	19	20	0.488
Ly et al. [50]	2002	Asian	0	4	6	1	5	7	0.935
Zhang et al. [51]	2000	Asian	2	15	17	7	36	35	0.598
Zhang et al. [52]	1998	Asian	0	3	14	0	14	148	0.565
Yanagi et al. [53]	1996	Asian	12	12	22	2	7	57	0.013
Ramalho et al. [54]	1998	mix	13	23	20	7	11	18	0.050
Quevedo et al. [32]	2008	mix	11	46	10	9	37	13	0.050

The bold values emphasize that the data does not conform to the Hardy–Weinberg equilibrium, to facilitate the readers to scan the content
^a p value for Hardy–Weinberg equilibrium in the control group

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