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Table 4 ORs and 95% CI for postmenopausal osteoporosis and the VDR BsmI polymorphism under different genetic models

From: Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

Genetic model Population Pooled OR [95% CI] p Heterogeneity p value* Publication bias
Begg’s test p value
Additive (b vs. B) Caucasian 0.809 [0.678~0.965] 0.019 < 0.001 0.893
  Asian 1.353 [0.628~2.915] 0.440 < 0.001 0.881
  Mix 0.778 [0.530~1.144] 0.202 0.594 0.317
  overall 0.880 [0.729~1.063] 0.185 < 0.001 0.856
Recessive (bb vs. Bb/BB) Caucasian 0.736 [0.568~0.955] 0.021 < 0.001 0.853
  Asian 1.340 [0.442~4.061] 0.605 < 0.001 0.652
  Mix 0.585 [0.314~1.090] 0.091 0.862 0.317
  overall 0.813 [0.619~1.066] 0.134 < 0.001 0.815
Dominant (Bb/bb vs. BB) Caucasian 0.810 [0.654~1.004] 0.055 0.009 0.833
  Asian 2.107 [0.768~5.784] 0.148 0.033 0.806
  Mix 0.860 [0.426~1.736] 0.673 0.848 1
  overall 0.884 [0.715~1.092] 0.253 0.001 0.813
Bb vs. BB Caucasian 0.880 [0.754~1.027] 0.105 0.427 0.579
  Asian 1.206 [0.738~1.969] 0.455 0.627 0.117
  Mix 1.061 [0.501~2.248] 0.878 0.896 0.317
  overall 0.911 [0.788~1.053] 0.206 0.615 0.510
bb vs. BB Caucasian 0.701 [0.511~0.962] 0.028 < 0.001 0.895
  Asian 3.146 [0.566~17.50] 0.190 0.007 0.117
  Mix 0.612 [0.270~1.391] 0.241 0.952 0.317
  overall 0.811 [0.576~1.141] 0.228 < 0.001 0.937
  1. CI confidence interval
  2. * p value for heterogeneity test; random-effects model was used when p value for heterogeneity test < 0.05
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