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Table 4 ORs and 95% CI for postmenopausal osteoporosis and the VDR BsmI polymorphism under different genetic models

From: Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

Genetic model

Population

Pooled OR [95% CI] p

Heterogeneity p value*

Publication bias

Begg’s test p value

Additive (b vs. B)

Caucasian

0.809 [0.678~0.965] 0.019

< 0.001

0.893

 

Asian

1.353 [0.628~2.915] 0.440

< 0.001

0.881

 

Mix

0.778 [0.530~1.144] 0.202

0.594

0.317

 

overall

0.880 [0.729~1.063] 0.185

< 0.001

0.856

Recessive (bb vs. Bb/BB)

Caucasian

0.736 [0.568~0.955] 0.021

< 0.001

0.853

 

Asian

1.340 [0.442~4.061] 0.605

< 0.001

0.652

 

Mix

0.585 [0.314~1.090] 0.091

0.862

0.317

 

overall

0.813 [0.619~1.066] 0.134

< 0.001

0.815

Dominant (Bb/bb vs. BB)

Caucasian

0.810 [0.654~1.004] 0.055

0.009

0.833

 

Asian

2.107 [0.768~5.784] 0.148

0.033

0.806

 

Mix

0.860 [0.426~1.736] 0.673

0.848

1

 

overall

0.884 [0.715~1.092] 0.253

0.001

0.813

Bb vs. BB

Caucasian

0.880 [0.754~1.027] 0.105

0.427

0.579

 

Asian

1.206 [0.738~1.969] 0.455

0.627

0.117

 

Mix

1.061 [0.501~2.248] 0.878

0.896

0.317

 

overall

0.911 [0.788~1.053] 0.206

0.615

0.510

bb vs. BB

Caucasian

0.701 [0.511~0.962] 0.028

< 0.001

0.895

 

Asian

3.146 [0.566~17.50] 0.190

0.007

0.117

 

Mix

0.612 [0.270~1.391] 0.241

0.952

0.317

 

overall

0.811 [0.576~1.141] 0.228

< 0.001

0.937

  1. CI confidence interval
  2. * p value for heterogeneity test; random-effects model was used when p value for heterogeneity test < 0.05