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Table 1 Summary of the study design. DNA methylation and gene expression were assayed at 6 different time points for control adipocytes, proteomics only at four time points (24 and 48 h excluded). DNA methylation, gene expression, and proteins changes in the fructose-treated adipocytes were examined at 192 and 384 h, following the addition of 3 different doses of fructose (2.5 mM, 5 mM, 10 mM)

From: DNA methylation during human adipogenesis and the impact of fructose

Hours

Glucose (mM)

Fructose (mM)

Methylation

Gene expression

Proteomics

0

5

0

24 (1 day)

5

0

48 (2 days)

5

0

96 (4 days)

5

0

192 (8 days)

5

0, 2.5, 5, 10

384 (16 days)

5

0, 2.5, 5, 10