Table 5 The ten most significant pathways from the NASFinder TFs analysis on the 1437 significant DMRs at 384 h are displayed. The p value, the Network Activity Score (NAS), the identified TF, and the DMRs involved in each pathway are added
From: DNA methylation during human adipogenesis and the impact of fructose
| Pathways | NAS | p value | DMRs in the pathway | TF |
|---|---|---|---|---|
| BioCarta phospholipase C D1 in phospholipid-associated cell signaling | 0.322 | 0.005 | PRKCA | JUNB |
| BioCarta CBL-mediated ligand-induced downregulation of EGF receptors | 0.191 | 0.008 | PRKCA | MET |
| BioCarta activation of PKC through G protein-coupled receptor | 0.186 | 0.003 | PRKCA | NFKBIA |
| BioCarta apoptotic signaling in response to DNA damage | 0.167 | 0.011 | APAF1, BID, PRKCA | TP53 |
| BioCarta role of MEF2D in T cell apoptosis | 0.163 | 0.018 | MEF2D, PRKCA | EP300 |
| BioCarta FXR and LXR regulation of cholesterol metabolism | 0.115 | 0.010 | ABCA1, NR1H3 | RXRA |
| BioCarta cadmium induces DNA synthesis and proliferation in macrophages | 0.088 | 0.013 | PRKCA | MYC |
| BioCarta TPO signaling pathway | 0.064 | 0.029 | PRKCA, STAT5A | STAT3 |
| BioCarta effects of calcineurin in keratinocyte differentiation | 0.060 | 0.022 | PRKCA | SP3 |
| Reactome regulation of gene expression by hypoxia-inducible factor | 0.056 | 0.012 | CITED2 | HIF1A |