Table 6 Statistics for the genes identified by the NASFinder as involved in the TF pathways. These genes show significant changes at 384 h in their methylation level and gene expression. Four of them are differentially expressed also at the proteomic level. Changes between 384 and 0 h are displayed for each studied omics, together with the adjusted p value. The region on the gene where the DMR was found is added in the table
From: DNA methylation during human adipogenesis and the impact of fructose
Gene | DMR location | Delta Me | FDR Me | Log FC GE | adj Pval GE | Log FC Pr | adj Pval Pr |
|---|---|---|---|---|---|---|---|
ABCA1 | Intron | − 1.17E−01 | 5.39E−03 | 1.66E+00 | 1.46E−05 | – | – |
APAF1 | Promoter | 3.13E−02 | 1.29E−03 | − 3.00E+00 | 7.51E−11 | – | – |
BID | Promoter | − 3.31E−02 | 4.20E−02 | − 1.91E+00 | 7.89E−07 | – | – |
CITED2 | Promoter | 1.67E−02 | 1.17E−02 | − 1.14E+00 | 3.89E−03 | – | – |
ETS2 | Exon | − 5.49E−01 | 1.80E−02 | − 3.29E+00 | 1.65E−12 | – | – |
HMOX1 | Promoter | − 7.67E−02 | 4.73E−02 | 4.44E+00 | 1.23E−15 | – | – |
HSD17B4 | Promoter | − 1.19E−01 | 1.31E−02 | 1.74E+00 | 7.11E−06 | – | – |
ICAM1 | Promoter | − 4.91E−02 | 3.30E−03 | − 2.43E+00 | 1.19E−08 | − 7.39E−01 | 2.45E−05 |
MEF2D | Promoter | 2.51E−02 | 1.45E−02 | − 1.62E+00 | 1.17E−05 | – | – |
NCOR2* | Intron | − 1.26E−01 | 5.26E−03 | − 1.31E+00 | 5.45E−04 | – | – |
NR1H3 | Promoter | 2.05E−02 | 2.27E−02 | 4.83E+00 | 4.54E−18 | – | – |
PCNA | Promoter | − 6.65E−02 | 4.51E−02 | − 2.70E+00 | 2.02E−09 | – | – |
PRKCA | Promoter | − 7.76E−02 | 4.56E−02 | − 3.34E+00 | 6.50E−13 | − 1.26E+00 | 1.97E−06 |
RAC1*° | Promoter | − 9.51E−02 | 8.33E−03 | − 3.32E+00 | 1.56E−12 | − 8.47E−01 | 1.40E−05 |
RAN | Promoter | 2.87E−02 | 1.25E−02 | − 1.77E+00 | 4.33E−06 | − 8.19E−01 | 2.36E−05 |
ROCK1 | Promoter | − 2.05E−01 | 3.59E−02 | − 1.16E+00 | 5.75E−03 | – | – |
SREBF1 | Promoter | − 1.41E−01 | 3.96E−02 | 4.62E+00 | 2.43E−15 | – | – |
STAT5A | Promoter | − 1.30E−01 | 2.63E−02 | 3.03E+00 | 1.56E−11 | – | – |