GO term (BP) | DMGs associated |
---|---|
Dorsal/ventral neural tube patterning | 5 genes: Psen1 (hypermethylated), Gsc, Kif3a, Pax7, Ptch1 (hypomethylated) |
Neural crest cell migration | 14 genes: Pax6, Coro1c, Sema5a, Sema6d, Sema3b (hypermethylated), Ret, Efnb1, Kitlg, Isl1, Sox8, Sema6c, Sema7a, Gbx2, Sema4b (hypomethylated) |
Brain development, hippocampus development, orbitofrontal cortex development, cerebellum development | 59 genes: Fgfr1, Stk36, Hmgcs1, Pax6, Ptprs, Cdk5, Tp73, Bbs2, Casp3, Acat2, Cttnbp2, Ace, Ndrg4, Synj2, Ntf3, Gsx2, Ak2, Ager, Notch1, Psen1, Snrpb, Pygo2 (hypermethylated), Cast, Pfkfb3, Phlpp2, Lmx1a, Ogdh, Igf1r, Atp2b4, Akap5, Dclk2, Lhx5, Reln, Pafah1b1, Rara, Eif2b4, Fgfr2, Sstr1, Glud1, Gbx2, Sdf4, Rere, Dmrta2, Tmem57, Cxcr4, Sharpin, Unc5c, Irs2, Col4a1, Mdga1, Gabra5, Dpysl2, Pcdh19, Ddit4, Ptpn11, Hes5, Abcb1b, Ptch1, Cln5 (hypomethylated) |
Neuron differentiation, neuron projection development, positive regulation of neuron projection development, negative regulation of neuron projection development, axonogenesis, negative regulation of axonogenesis, axon guidance, negative regulation of axon extension involved in axon guidance, axon regeneration, negative regulation of axon regeneration, negative regulation of dendrite development | 112 genes: Wnt10a, Wnt5b, Cebpb, Fgfr1, Ncdn, Ager, Cdk5, Wnt7b, Cd44, Prkci, Kidins220, Fam134c, Nme2, Ndrg4, Ntrk1, Neu1, Tmem30a, Lrp1, Actb, Erbb3, Lrtm2, Flot1, Pax6, Slitrk2, Notch1, Gas7, Casp3, Sema5a, Sema6d, Sema3b, Dhfr, Folr1, Klk8, Fat3, Cyth2, Bag1, Psen1, Mbp, Ntf3, Kif5a, Etv1, B3gnt2 (hypermethylated), Ret, Sox11, Neurog1, Pld2, Ptprm, Vapa, Rb1, Itgb1, Pten, Uhmk1, Igf1r, Lingo1, App, Sema7a, Camsap1, Map4, Runx3, Arsb, Ltk, Katnb1, Ankrd1, Kif3c, Bcl11a, Ntrk2, Adamts1, Reln, Ngfr, Scarb2, Bag5, Mag, Fkbp4, Adcy5, Cspg4, Lrig2, Pafah1b1, Paqr3, Fgfr2, Adcy1, Atl1, Stk11, Nkx2-8, Lrrn3, Rtn4r, Ptpn11, Picalm, Lmx1a, Isl1, Ddit4, Wnt3, Kdm2a, Sema6c, Sema4b, Jak2, Ctnna1, Epha4, Arf6, Hes5, Ppia, Acsl4, Runx2, Wnt7a, Lrp4, Efna2, Efnb1, Dpysl2, Ttc8, Gbx2, Unc5c, Kif26a, Kif26b (hypomethylated) |
Astrocyte differentiation, oligodendrocyte differentiation | 11 genes: Notch1, S100b, Pax6, Bnip3, Cdk5 (hypermethylated), Hes5, Ptprj, Ntrk2, Olig1, Sox8, Nkx6-1 (hypomethylated) |
Synapse organization | 7 genes: Sncg, Wnt7b, Klk8 (hypermethylated), LRRTM1, Lmx1a, Wnt7a, Lrp4 (hypomethylated) |
Synaptic transmission, glutamatergic, positive regulation of synaptic transmission, glutamatergic | 13 genes: P2rx1, Cnih2, Grin2d, Grin1, Cdk5, Egfr, Cckbr, Ntrk1 (hypermethylated), Clcn3, Unc13b, Ntrk2, Reln, Ngfr (hypomethylated) |
Learning or memory, memory, associative learning | 29 genes: Egfr, Casp3, Sts, Psen1, S100b, Dyx1c1, Prkar1b, Ntrk1, Grin1, Abca7, Klk8, Cebpb, Paip2, Th, Nrgn, Cdk5 (hypermethylated), Pafah1b1, Pten, Igf2, Lmx1a, Itpr3, Sorcs3, Adrb1, Plk2, Reln, Chrnb2, Cacna1d, Gabra5, Neurod2 (hypomethylated) |