|
Dietary BCAAs (mg/g protein)
|
GRS in classified mode
|
GRS in continuous mode
|
|---|
|
< 22
|
22–24
|
≥ 25
|
P for Trend
|
P for interaction
|
Per 1 allele
|
P value
|
P for interaction
|
|---|
|
Total BCAAs
| | | | |
0.001
| | |
< 0.001
|
|
T1 (n = 289)
|
1
|
0.71 (0.34–1.36)
|
0.63 (0.32–1.24)
|
0.19
| |
0.95 (0.88–1.01)
|
0.11
| |
|
T2 (n = 290)
|
1
|
1.00 (0.53–1.90)
|
2.22 (1.12–4.12)
|
0.012
| |
1.10 (1.02–1.17)
|
0.006
| |
|
T3 (n = 289)
|
1
|
2.30 (1.19–4.46)
|
2.98 (1.54–5.76)
|
0.001
| |
1.13 (1.06–1.21)
|
< 0.001
| |
|
Isoleucine
| | | | |
< 0.001
| | |
< 0.001
|
|
T1 (n = 289)
|
1
|
0.63 (0.32–1.22)
|
0.58 (0.29–1.13)
|
0.12
| |
0.94 (0.88–1.01)
|
0.08
| |
|
T2 (n = 290)
|
1
|
1.15 (0.61–2.18)
|
2.39 (1.29–4.44)
|
0.006
| |
1.10 (1.03–1.17)
|
0.005
| |
|
T3 (n = 289)
|
1
|
2.13 (1.11–4.07)
|
2.95 (1.53–5.68)
|
0.001
| |
1.13 (1.06–1.21)
|
< 0.001
| |
|
Leucine
| | | | |
0.001
| | |
< 0.001
|
|
T1 (n = 289)
|
1
|
0.71 (0.37–1.37)
|
0.62 (0.32–1.23)
|
0.18
| |
0.94 (0.88–1.01)
|
0.10
| |
|
T2 (n = 290)
|
1
|
1.08 (0.57–2.04)
|
2.26 (1.22–4.19)
|
0.011
| |
1.10 (1.03–1.17)
|
0.006
| |
|
T3 (n = 289)
|
1
|
2.16 (1.11–4.18)
|
3.00 (1.56–5.81)
|
0.001
| |
1.14 (1.06–1.21)
|
< 0.001
| |
|
Valine
| | | | |
0.003
| | |
0.001
|
|
T1 (n = 289)
|
1
|
0.72 (0.37–1.39)
|
0.78 (0.40–1.52)
|
0.48
| |
0.96 (0.90–1.03)
|
0.25
| |
|
T2 (n = 290)
|
1
|
1.12 (0.59–2.14)
|
1.88 (1.01–3.50)
|
0.046
| |
1.09 (1.02–1.16)
|
0.014
| |
|
T3 (n = 289)
|
1
|
2.10 (1.08–4.08)
|
2.95 (1.52–5.72)
|
0.001
| |
1.13 (1.05–1.20)
|
0.001
| |
- The multivariate logistic regression was used for estimation of ORs and 95% confidence interval (CI)
- BCAAs branched-chain amino acids, GRS genetic risk score, T2D type 2 diabetes
- aResults were adjusted for age, sex, BMI, current drinkers, current smokers, exercise regularly, family history of diabetes, cardiovascular disease, red meat intake, and total energy intake
