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Table 2 The odds ratio of T2D by GRS in classified and continuous form according to dietary BCAAs in thirdsa

From: Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese

Dietary BCAAs (mg/g protein)

GRS in classified mode

GRS in continuous mode

< 22

22–24

≥ 25

P for Trend

P for interaction

Per 1 allele

P value

P for interaction

Total BCAAs

    

0.001

  

< 0.001

 T1 (n = 289)

1

0.71 (0.34–1.36)

0.63 (0.32–1.24)

0.19

 

0.95 (0.88–1.01)

0.11

 

 T2 (n = 290)

1

1.00 (0.53–1.90)

2.22 (1.12–4.12)

0.012

 

1.10 (1.02–1.17)

0.006

 

 T3 (n = 289)

1

2.30 (1.19–4.46)

2.98 (1.54–5.76)

0.001

 

1.13 (1.06–1.21)

< 0.001

 

Isoleucine

    

< 0.001

  

< 0.001

 T1 (n = 289)

1

0.63 (0.32–1.22)

0.58 (0.29–1.13)

0.12

 

0.94 (0.88–1.01)

0.08

 

 T2 (n = 290)

1

1.15 (0.61–2.18)

2.39 (1.29–4.44)

0.006

 

1.10 (1.03–1.17)

0.005

 

 T3 (n = 289)

1

2.13 (1.11–4.07)

2.95 (1.53–5.68)

0.001

 

1.13 (1.06–1.21)

< 0.001

 

Leucine

    

0.001

  

< 0.001

 T1 (n = 289)

1

0.71 (0.37–1.37)

0.62 (0.32–1.23)

0.18

 

0.94 (0.88–1.01)

0.10

 

 T2 (n = 290)

1

1.08 (0.57–2.04)

2.26 (1.22–4.19)

0.011

 

1.10 (1.03–1.17)

0.006

 

 T3 (n = 289)

1

2.16 (1.11–4.18)

3.00 (1.56–5.81)

0.001

 

1.14 (1.06–1.21)

< 0.001

 

Valine

    

0.003

  

0.001

 T1 (n = 289)

1

0.72 (0.37–1.39)

0.78 (0.40–1.52)

0.48

 

0.96 (0.90–1.03)

0.25

 

 T2 (n = 290)

1

1.12 (0.59–2.14)

1.88 (1.01–3.50)

0.046

 

1.09 (1.02–1.16)

0.014

 

 T3 (n = 289)

1

2.10 (1.08–4.08)

2.95 (1.52–5.72)

0.001

 

1.13 (1.05–1.20)

0.001

 
  1. The multivariate logistic regression was used for estimation of ORs and 95% confidence interval (CI)
  2. BCAAs branched-chain amino acids, GRS genetic risk score, T2D type 2 diabetes
  3. aResults were adjusted for age, sex, BMI, current drinkers, current smokers, exercise regularly, family history of diabetes, cardiovascular disease, red meat intake, and total energy intake