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Table 3 The odds ratio of T2D by dietary BCAAs in classified and continuous form according to GRS in thirdsa

From: Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese

GRS

Dietary BCAAs in classified mode

Dietary BCAAs in continuous mode

T1

T2

T3

P for trend

P for interaction

Per 10 mg/g protein

P value

P for interaction

Total BCAAs

    

0.001

  

0.038

 < 22 (n = 293)

1

0.56 (0.28–1.10)

0.46 (0.22–0.95)

0.040

 

0.95 (0.88–1.03)

0.20

 

 22–24 (n = 279)

1

1.11 (0.59–2.08)

2.22 (1.15–4.31)

0.021

 

1.05 (0.98–1.12)

0.17

 

 ≥ 25 (n = 296)

1

2.19 (1.17–4.10)

2.90 (1.54–5.47)

0.001

 

1.07 (1.00–1.15)

0.049

 

Isoleucine

    

< 0.001

  

0.038

 < 22 (n = 293)

1

0.60 (0.30–1.18)

0.50 (0.24–1.18)

0.07

 

0.80 (0.57–1.13)

0.21

 

 22–24 (n = 279)

1

1.36 (0.72–2.56)

2.36 (1.21–4.59)

0.012

 

1.23 (0.92–1.65)

0.16

 

 ≥ 25 (n = 296)

1

2.53 (1.34–4.76)

3.29 (1.74–6.25)

< 0.001

 

1.38 (1.00–1.89)

0.047

 

Leucine

    

0.001

  

0.039

 < 22 (n = 293)

1

0.55 (0.28–1.10)

0.47 (0.22–0.98)

0.050

 

0.91 (0.79–1.05)

0.21

 

 22–24 (n = 279)

1

1.22 (0.65–2.28)

2.24 (1.15–4.35)

0.019

 

1.09 (0.96–1.24)

0.17

 

 ≥ 25 (n = 296)

1

2.23 (1.19–4.19)

3.06 (1.61–5.79)

0.001

 

1.15 (1.00–1.32)

0.047

 

Valine

    

0.003

  

0.037

 < 22 (n = 293)

1

0.59 (0.30–1.17)

0.49 (0.24–1.03)

0.06

 

0.81 (0.60–1.09)

0.17

 

 22–24 (n = 279)

1

1.12 (0.60–2.10)

2.07 (1.07–4.01)

0.035

 

1.19 (0.92–1.54)

0.20

 

 ≥ 25 (n = 296)

1

1.53 (0.82–2.86)

2.49 (1.33–4.67)

0.004

 

1.31 (0.99–1.74)

0.06

 
  1. The multivariate logistic regression was used for estimation of ORs and 95% confidence interval (CI)
  2. BCAAs branched-chain amino acids, GRS genetic risk score, T2D type 2 diabetes
  3. aResults were adjusted for age, sex, BMI, current drinkers, current smokers, exercise regularly, family history of diabetes, cardiovascular disease, red meat intake, and total energy intake