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Table 4 Circulating BCAAs by classified and continuous mode of GRSa

From: Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese

Circulating BCAAs

GRS in classified mode

GRS in continuous mode

< 22 (n = 293)

22–24 (n = 279)

≥ 25 (n = 296)

Effect size

P for trend

Effect size

P value

Total BCAAs

139.5(26.8)

140.5(25.7)

146.3(31.5)b

3.6(1.1)

0.002

0.028(0.010)

0.003

Isoleucine

24.3(8.6)

23.5(8.76)

24.9 (8.8)

0.4 (0.4)

0.27

0.004(0.007)

0.59

Leucine

16.1(7.1)

15.6(8.32)

15.9(7.9)

0.09(0.3)

0.29

-0.001(0.007)

0.86

Valine

99.1(21.9)

101.4(20.5)

106.0(25.0)b

3.0(0.9)

0.001

0.031(0.009)

0.001

  1. The general linear model was used for estimation of mean (SD) for circulating BCAAs and linear regression model for β coefficient (SE)
  2. BCAAs branched-chain amino acids, GRS genetic risk score, T2D type 2 diabetes
  3. aResults were adjusted for age, sex, BMI, current drinkers, current smokers, exercise regularly, family history of diabetes, cardiovascular disease, red meat intake, and total energy intake.
  4. bComparing to the lowest GRS group, P < 0.05.