Inhibition of the TCONS_00230836 alleviated stearic acid-induced insulin secretion reduction in islets and β-TC6 cells. a The expression of the lncRNA TCONS_00230836 in islets under high-stearic acid diet. b The lncRNA TCONS_00230836 level in β-TC6 cells under stearic acid treatment. c Representative images of FISH in β-TC6 cells showing the change of lncRNA TCONS_00230836 expression after transfection of the lncRNA TCONS_00230836 Smart Silencer in the presence of stearic acid. Scale bar, 10 μm. d Effect of the lncRNA TCONS_00230836 Smart Silencer on GSIS in the islets isolated from mice in the presence of stearic acid. e Restoration of stearic acid-induced glucose-stimulated insulin secretion (GSIS) impairment after transfection of the lncRNA TCONS_00230836 Smart Silencer in β-TC6 cells. Ctrl control group, SA stearic acid, si-lnc836 Smart Silencer for lncRNA TCONS_00230836. *p < 0.05, **p < 0.01 versus the control group; ^p < 0.05, ^^p < 0.01 versus the stearic acid group. n =5 and 4 independent animal experiments per group in A and D, respectively. n = 4 independent cell cultures per group.