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Fig. 5 | Genes & Nutrition

Fig. 5

From: TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis

Fig. 5

The lncRNA TCONS_00230836 did not significantly reverse stearic acid-induced β-TC6 cell apoptosis. a, b Effect of the Smart Silencer for TCONS_00230836 on stearic acid-induced cell viability by CCK8 assay and cell death by LDH measurement, separately. c FCM revealed that the number of apoptotic cells was not altered after TCONS_00230836 inhibition under stearic acid treatment. d No significant changes in the expression of cleaved-caspase3, cleaved-Parp1, and Bcl-2 after inhibition of the lncRNA TCONS_00230836 by western blot analysis. NS not significant, SA stearic acid, si-lnc836 Smart Silencer for lncRNA TCONS_00230836. n = 3 independent cell cultures per group. *p < 0.05, **p < 0.01 versus the control group; ^p < 0.05, ^^p < 0.01 versus the stearic acid group

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