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Fig. 8 | Genes & Nutrition

Fig. 8

From: TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis

Fig. 8

Inhibition of the lncRNA TCONS_00230836 apparently recovered ER stress-related proteins in stearic acid-treated mice islets. a The expression of Phospho-PERK and Phospho-eIF2α proteins in mice islet under high-stearic-acid treatment by the lncRNA TCONS_00230836 Smart Silencer. b The alteration of ATF-6 and IRE1α protein levels after transfection of the TCONS_00230836 Smart Silencer in islet exposed to high level of stearic-acid. NS not significant, SA stearic-acid, si-lnc836 transfection of the Smart Silencer for the lncRNA TCONS_00230836. *p < 0.05 versus the control group; ^p < 0.05 versus SA group. n = 5 independent animal experiments per group

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Genes & Nutrition

ISSN: 1865-3499

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