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Fig. 9 | Genes & Nutrition

Fig. 9

From: TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis

Fig. 9

Alterations of candidate ER stress-related mRNAs expressions after transfection of lncRNA TCONS_00230836 Smart Silencer. a, b The positive and negative co-expression network of lncRNA TCONS_00230836 and target mRNAs (positively related: Hp, Icam1, SAA3, Lcn2, Alpk1, Serping1, Vnn3, Rgs16, Gm16685, Lats2, Zc3h12a. Negatively related: Prn, Bcas3, Otub2, Afmid, Snapin, Srgap2, 2010107G23Rik, Sult1a1, Ipo9, Gm15350, Gm16272, Ncor2) specifically in stearic acid-treated β-TC6 cells. Red circle nodes represent upregulated lncRNA TCONS_00230836. Genes labeled with yellow and blue squares refer to upregulated and downregulated mRNAs, respectively. Red lines represent a positive correlation and green lines refer to negative correlation. c Effect of lncRNA TCONS_00230836 Smart Silencer on stearic acid-increased ER stress-related mRNAs expressions. d Changes in the downregulated ER stress-related mRNAs after silencing lncRNA TCONS_00230836. n=3,  *p < 0.05, **p < 0.01, ***p < 0.001, versus the ctrl group; ^p < 0.05, ^^p < 0.01, ^^^p < 0.001 versus SA group

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Genes & Nutrition

ISSN: 1865-3499

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