Table 2 The positive findings of the associations between vitamin D pathway genes polymorphisms and clinical features of PTB patients
SNP | Allele | Clinical features | Group | Genetypes n (%) | P value | Alleles n (%) | P value | |||
|---|---|---|---|---|---|---|---|---|---|---|
(M/m) | MM | Mm | mm | M | m | |||||
CYP27A1 | Â | |||||||||
 rs17470271 | A/T | Leukopenia | + | 32 (96.97) | 1 (3.03) | 0 | 0.106 | 65 (98.48) | 1 (1.52) | 0.039 |
|  |  |  | − | 374 (82.93) | 75 (16.63) | 2 (0.44) |  | 823 (91.24) | 79 (8.76) |  |
 rs933994 | C/T | Drug resistance | + | 59 (78.67) | 15 (20.00) | 1 (1.33) | 0.149 | 133 (88.67) | 17 (11.33) | 0.047 |
|  |  |  | − | 276 (67.81) | 116 (28.50) | 15 (3.69) |  | 668 (82.03) | 146 (17.94) |  |
GC | Â | |||||||||
 rs7041 | A/C | Pulmonary infection | + | 57 (53.77) | 39 (36.79) | 10 (9.43) | 0.031 | 153 (72.17) | 59 (27.83) | 0.050 |
|  |  |  | − | 229 (60.58) | 136 (35.98) | 13 (3.44) |  | 594 (78.57) | 162 (21.43) |  |
 rs3733359 | G/A | Fever | + | 34 (39.08) | 40 (45.98) | 13 (14.94) | 0.094 | 108 (62.07) | 66 (37.93) | 0.027 |
|  |  |  | − | 198 (50.38) | 159 (40.46) | 36 (9.16) |  | 555 (70.61) | 231 (29.39) |  |
 rs16847024 | C/T | Fever | + | 59 (67.82) | 23 (26.44) | 5 (5.75) | 0.036 | 141 (81.03) | 33 (18.97) | 0.009 |
|  |  |  | − | 310 (78.88) | 75 (19.08) | 8 (2.04) |  | 695 (88.42) | 91 (11.58) |  |
 rs16847024 | C/T | DILI | + | 48 (68.57) | 18 (25.71) | 4 (5.71) | 0.092 | 114 (81.42) | 26 (18.58) | 0.027 |
|  |  |  | − | 325 (78.50) | 80 (19.32) | 9 (2.17) |  | 730 (88.16) | 98 (11.84) |  |
DHCR7 | Â | |||||||||
 rs12785878 | G/T | Pulmonary infection | + | 42 (39.62) | 45 (42.45) | 19 (17.92) | 0.047 | 129 (60.85) | 83 (39.15) | 0.024 |
|  |  |  | − | 103 (27.25) | 188 (49.74) | 87 (23.01) |  | 394 (52.12) | 362 (47.88) |  |