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Table 2 The positive findings of the associations between vitamin D pathway genes polymorphisms and clinical features of PTB patients

From: Association of vitamin D pathway genes polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population

SNP Allele Clinical features Group Genetypes n (%) P value Alleles n (%) P value
(M/m) MM Mm mm M m
CYP27A1  
 rs17470271 A/T Leukopenia + 32 (96.97) 1 (3.03) 0 0.106 65 (98.48) 1 (1.52) 0.039
    374 (82.93) 75 (16.63) 2 (0.44)   823 (91.24) 79 (8.76)  
 rs933994 C/T Drug resistance + 59 (78.67) 15 (20.00) 1 (1.33) 0.149 133 (88.67) 17 (11.33) 0.047
    276 (67.81) 116 (28.50) 15 (3.69)   668 (82.03) 146 (17.94)  
GC  
 rs7041 A/C Pulmonary infection + 57 (53.77) 39 (36.79) 10 (9.43) 0.031 153 (72.17) 59 (27.83) 0.050
    229 (60.58) 136 (35.98) 13 (3.44)   594 (78.57) 162 (21.43)  
 rs3733359 G/A Fever + 34 (39.08) 40 (45.98) 13 (14.94) 0.094 108 (62.07) 66 (37.93) 0.027
    198 (50.38) 159 (40.46) 36 (9.16)   555 (70.61) 231 (29.39)  
 rs16847024 C/T Fever + 59 (67.82) 23 (26.44) 5 (5.75) 0.036 141 (81.03) 33 (18.97) 0.009
    310 (78.88) 75 (19.08) 8 (2.04)   695 (88.42) 91 (11.58)  
 rs16847024 C/T DILI + 48 (68.57) 18 (25.71) 4 (5.71) 0.092 114 (81.42) 26 (18.58) 0.027
    325 (78.50) 80 (19.32) 9 (2.17)   730 (88.16) 98 (11.84)  
DHCR7  
 rs12785878 G/T Pulmonary infection + 42 (39.62) 45 (42.45) 19 (17.92) 0.047 129 (60.85) 83 (39.15) 0.024
    103 (27.25) 188 (49.74) 87 (23.01)   394 (52.12) 362 (47.88)