Skip to main content

Table 4 KEGG pathways of differentially expressed miRNAs in early glycaemic impairment

From: The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study

 

p

n. of genes

n. of miRNAs

A) KEGG pathway

 Huntington’s disease

0.000000019

3

1

 Hippo signalling pathway

0.0000013

18

2

 Lysine degradation

0.000046

8

1

 Protein processing in endoplasmic reticulum

0.000239

25

1

 Proteoglycans in cancer

0.002373

22

1

 Viral carcinogenesis

0.004420

26

1

 Glycosaminoglycan biosynthesis - chondroitin sulfate/dermatan sulfate

0.007630

2

1

 Colorectal cancer

0.013249

3

1

 Central carbon metabolism in cancer

0.023230

9

1

 Endocytosis

0.026468

22

1

 Transcriptional misregulation in cancer

0.027697

4

1

 Thyroid hormone signalling pathway

0.038555

13

1

 FoxO signalling pathway

0.041500

17

1

 Adherens junction

0.041500

10

1

B) KEGG pathway

 Hippo signalling pathway

0.00000139

18

2

  1. A) Pathways enrichment analysis of single deregulated miRNAs. B) Pathways union of miRNAs is also reported. Pathways were classified according to KEGG functional annotations to identify top pathways that were actively regulated by miRNAs. Merged p-value is extracted by combining calculated significance levels using Fisher’s exact test (hypergeometric distribution) with a p-value threshold=0.05 and MicroT threshold=0.8