Serum iron status and the risk of breast cancer in the European population: a two-sample Mendelian randomisation study

Table 1 Effect of iron concentration GWAS identified variants on breast cancer

SNPs	Chr: BP (Build 37)	Locus	Effect/other allele	Iron (μmol/L)		Overall breast cancer		ER-positive breast cancer		ER-negative breast cancer
SNPs	Chr: BP (Build 37)	Locus	Effect/other allele	Beta^b (SE)	P value	Beta^c (SE)	P value	Beta^c (SE)	P value	Beta^c (SE)	P value
rs8177240	3: 133,477,701	TF	T/G	−0.066(0.007)	6.65E−20	−0.014 (0.007)	0.040	−0.014 (0.008)	0.072	−0.012 (0.012)	0.304
rs1800562^a	6: 26,093,141	HFE	A/G	0.328(0.016)	2.72E−97	−0.003 (0.014)	0.831	0.010 (0.016)	0.535	−0.027 (0.025)	0.288
rs7385804	7: 100,235,970	TFR2	A/C	0.064(0.007)	1.36E−18	0.016 (0.007)	0.015	0.010 (0.008)	0.225	0.017 (0.012)	0.151
rs855791^a	22: 37,462,936	TMPRSS6	A/G	−0.181(0.007)	1.32E−139	−0.003 (0.006)	0.627	0.001 (0.008)	0.852	−0.013 (0.012)	0.255
rs1799945^a	6: 26,091,179	HFE	C/G	−0.189(0.010)	1.10E−81	−0.001 (0.009)	0.913	−0.003 (0.011)	0.804	−0.014 (0.016)	0.380

^a3 SNPs used in the conservative analyses. GWAS genome-wide association studies, SNPs single nucleotide polymorphisms, Chr chromosome, BP base pair, SE standard error, ER oestrogen receptor
^bBeta units are per-allele effect estimates in iron concentrations
^cPer-allele logarithm of the odds ratios between breast cancer cases and controls

ISSN: 1865-3499