Fig. 1From: Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesisWorkflow of methods of analysis of included papers after literature search. Where no raw or normalised global gene expression data was available, papers were summarised narratively. Normalisation was conducted using the ArrayAnalysis online workflow (available at: arrayanalysis.org) according to the microarray chip type. Where only normalised global gene expression data was available, the data entered the pipeline after the normalisation step. High responders were defined as those that lost ≥ 5% body weight over the intervention period. Comparisons between included papers were made at the pathway level. DEGs, differentially expressed genes, defined as any gene with an adjusted p value < 0.05; HR, high responder; LR, low responderBack to article page