Table 4 The interaction between dietary BCAAs and GRS on the circulating BCAA level
Dietary BCAAs (mg) | Genetic risk score | Effect size | P for trend | P for interaction | |
|---|---|---|---|---|---|
< 4 (n = 424) | ≥ 4 (n = 444) | ||||
Total BCAAs | 0.015 | ||||
 T1 (n = 289) | 139.95 (29.48) | 139.53 (26.71) | 0.55 (3.34) | 0.87 | |
 T2 (n = 290) | 140.36 (24.87) | 144. 80 (28.06) | 1.93 (3.27) | 0.56 | |
 T3 (n = 289) | 139.10 (29.80) | 147.43 (29.10)* | 9.19 (3.31) | 0.006 | |
Isoleucine | 0.054 | ||||
 T1 (n = 289) | 23.80 (9.47) | 24.38 (9.64) | 0.61 (1.13) | 0.59 | |
 T2 (n = 290) | 23.73 (8.94) | 24.77 (9.55) | 0.98 (1.17) | 0.40 | |
 T3 (n = 289) | 24.06 (8.18) | 24.45 (10.08) | 0.93 (1.07) | 0.39 | |
Leucine | 0.64 | ||||
 T1 (n = 289) | 15.47 (7.06) | 15.42 (6.86) | − 0.55 (0.84) | 0.52 | |
 T2 (n = 290) | 15.44 (5.55) | 15.20 (6.52) | − 0.64 (0.77) | 0.41 | |
 T3 (n = 289) | 16.54 (8.22) | 16.42 (10.17) | 0.70 (1.07) | 0.52 | |
Valine | 0.046 | ||||
 T1 (n = 289) | 101.57 (26.03) | 100.54 (21.70) | 0.37 (2.91) | 0.90 | |
 T2 (n = 290) | 100.49 (20.81) | 104.34 (22.44) | 1.99 (2.70) | 0.46 | |
 T3 (n = 289) | 98.22 (21.91) | 106.30 (21.51)* | 7.34 (2.58) | 0.005 | |