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Table 1 Demographic profiles about the selected AD and AD proxy phenotype GWAS datasets

From: Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer’s disease

GWAS datasets AD or AD proxy Controls or proxy controls
N % female Mean AAO (s.d) N % female Mean AAE (s.d)
IGAP ADGC 14,428 59.3 71.1 (17.3) 14,562 59.3 76.2 (9.9)
IGAP CHARGE 2137 67.3 82.6 (12) 13,474 55.8 76.7 (8.2)
IGAP EADI 2240 65 75.4 (9.1) 6631 60.6 78.9 (7.0)
IGAP GERAD 3177 64 73.0 (0.2) 7277 51.8 51.0 (0.1)
UK Biobank AD proxy 42,034 65.9 - 272,244 - -
Maternal AD group from UK Biobank 27,696 100 - 260,980 - -
Paternal AD group from UK Biobank 14,338 0 - 245,941 - -
  1. AD Alzheimer’s disease, AAO age at onset, AAE age at examination