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Table 2 Main characteristics of 11 selected plasma vitamin C genetic variants

From: Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer’s disease

SNP

Chromosome

Position (GRCh37)

EA

NEA

EAF

Beta

SE

P value

Gene

R2a

R2b

rs6693447

1

2330190

T

G

0.551

0.039

0.006

6.25E−10

RER1

0.08%

0.08%

rs13028225

2

220031255

T

C

0.857

0.102

0.009

2.38E−30

SLC23A3

0.25%

0.26%

rs33972313

5

138715502

C

T

0.968

0.36

0.018

4.61E−90

SLC23A1

0.76%

0.80%

rs10051765

5

176799992

C

T

0.342

0.039

0.007

3.64E−09

RGS14

0.06%

0.07%

rs7740812

6

52725787

G

A

0.594

0.038

0.006

1.88E−09

GSTA5

0.08%

0.07%

rs174547

11

61570783

C

T

0.328

0.036

0.007

3.84E−08

FADS1

0.05%

0.06%

rs117885456

12

96249111

A

G

0.087

0.078

0.012

1.70E−11

SNRPF

0.08%

0.10%

rs2559850

12

102093459

A

G

0.598

0.058

0.006

6.30E−20

CHPT1

0.18%

0.16%

rs10136000

14

105253581

A

G

0.283

0.04

0.007

1.33E−08

AKT1

0.06%

0.06%

rs56738967

16

79740541

C

G

0.321

0.041

0.007

7.62E−10

MAF

0.07%

0.07%

rs9895661

17

59456589

T

C

0.817

0.063

0.008

1.05E−14

BCAS3

0.12%

0.12%

  1. SNP single-nucleotide polymorphism, EA effect allele, NEA non-effect allele, EAF effect allele frequency, SE standard error. Beta is the regression coefficient based on the vitamin C raising allele (effect allele); R2, the proportion of vitamin C variance explained by the selected genetic variants; a and b, the proportion of plasma vitamin C variance R2 explained by the selected genetic variants was calculated using the first formula and the second formula