|
SNP
|
Chromosome
|
Position (GRCh37)
|
EA
|
NEA
|
EAF
|
Beta
|
SE
|
P value
|
Gene
|
R2a
|
R2b
|
|---|
|
rs6693447
|
1
|
2330190
|
T
|
G
|
0.551
|
0.039
|
0.006
|
6.25E−10
|
RER1
|
0.08%
|
0.08%
|
|
rs13028225
|
2
|
220031255
|
T
|
C
|
0.857
|
0.102
|
0.009
|
2.38E−30
|
SLC23A3
|
0.25%
|
0.26%
|
|
rs33972313
|
5
|
138715502
|
C
|
T
|
0.968
|
0.36
|
0.018
|
4.61E−90
|
SLC23A1
|
0.76%
|
0.80%
|
|
rs10051765
|
5
|
176799992
|
C
|
T
|
0.342
|
0.039
|
0.007
|
3.64E−09
|
RGS14
|
0.06%
|
0.07%
|
|
rs7740812
|
6
|
52725787
|
G
|
A
|
0.594
|
0.038
|
0.006
|
1.88E−09
|
GSTA5
|
0.08%
|
0.07%
|
|
rs174547
|
11
|
61570783
|
C
|
T
|
0.328
|
0.036
|
0.007
|
3.84E−08
|
FADS1
|
0.05%
|
0.06%
|
|
rs117885456
|
12
|
96249111
|
A
|
G
|
0.087
|
0.078
|
0.012
|
1.70E−11
|
SNRPF
|
0.08%
|
0.10%
|
|
rs2559850
|
12
|
102093459
|
A
|
G
|
0.598
|
0.058
|
0.006
|
6.30E−20
|
CHPT1
|
0.18%
|
0.16%
|
|
rs10136000
|
14
|
105253581
|
A
|
G
|
0.283
|
0.04
|
0.007
|
1.33E−08
|
AKT1
|
0.06%
|
0.06%
|
|
rs56738967
|
16
|
79740541
|
C
|
G
|
0.321
|
0.041
|
0.007
|
7.62E−10
|
MAF
|
0.07%
|
0.07%
|
|
rs9895661
|
17
|
59456589
|
T
|
C
|
0.817
|
0.063
|
0.008
|
1.05E−14
|
BCAS3
|
0.12%
|
0.12%
|
- SNP single-nucleotide polymorphism, EA effect allele, NEA non-effect allele, EAF effect allele frequency, SE standard error. Beta is the regression coefficient based on the vitamin C raising allele (effect allele); R2, the proportion of vitamin C variance explained by the selected genetic variants; a and b, the proportion of plasma vitamin C variance R2 explained by the selected genetic variants was calculated using the first formula and the second formula
