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Table 2 Main characteristics of 11 selected plasma vitamin C genetic variants

From: Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer’s disease

SNP Chromosome Position (GRCh37) EA NEA EAF Beta SE P value Gene R2a R2b
rs6693447 1 2330190 T G 0.551 0.039 0.006 6.25E−10 RER1 0.08% 0.08%
rs13028225 2 220031255 T C 0.857 0.102 0.009 2.38E−30 SLC23A3 0.25% 0.26%
rs33972313 5 138715502 C T 0.968 0.36 0.018 4.61E−90 SLC23A1 0.76% 0.80%
rs10051765 5 176799992 C T 0.342 0.039 0.007 3.64E−09 RGS14 0.06% 0.07%
rs7740812 6 52725787 G A 0.594 0.038 0.006 1.88E−09 GSTA5 0.08% 0.07%
rs174547 11 61570783 C T 0.328 0.036 0.007 3.84E−08 FADS1 0.05% 0.06%
rs117885456 12 96249111 A G 0.087 0.078 0.012 1.70E−11 SNRPF 0.08% 0.10%
rs2559850 12 102093459 A G 0.598 0.058 0.006 6.30E−20 CHPT1 0.18% 0.16%
rs10136000 14 105253581 A G 0.283 0.04 0.007 1.33E−08 AKT1 0.06% 0.06%
rs56738967 16 79740541 C G 0.321 0.041 0.007 7.62E−10 MAF 0.07% 0.07%
rs9895661 17 59456589 T C 0.817 0.063 0.008 1.05E−14 BCAS3 0.12% 0.12%
  1. SNP single-nucleotide polymorphism, EA effect allele, NEA non-effect allele, EAF effect allele frequency, SE standard error. Beta is the regression coefficient based on the vitamin C raising allele (effect allele); R2, the proportion of vitamin C variance explained by the selected genetic variants; a and b, the proportion of plasma vitamin C variance R2 explained by the selected genetic variants was calculated using the first formula and the second formula