Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer’s disease

Genes & Nutrition

Table 2 Main characteristics of 11 selected plasma vitamin C genetic variants

SNP	Chromosome	Position (GRCh37)	EA	NEA	EAF	Beta	SE	P value	Gene	R^2a	R^2b
rs6693447	1	2330190	T	G	0.551	0.039	0.006	6.25E−10	RER1	0.08%	0.08%
rs13028225	2	220031255	T	C	0.857	0.102	0.009	2.38E−30	SLC23A3	0.25%	0.26%
rs33972313	5	138715502	C	T	0.968	0.36	0.018	4.61E−90	SLC23A1	0.76%	0.80%
rs10051765	5	176799992	C	T	0.342	0.039	0.007	3.64E−09	RGS14	0.06%	0.07%
rs7740812	6	52725787	G	A	0.594	0.038	0.006	1.88E−09	GSTA5	0.08%	0.07%
rs174547	11	61570783	C	T	0.328	0.036	0.007	3.84E−08	FADS1	0.05%	0.06%
rs117885456	12	96249111	A	G	0.087	0.078	0.012	1.70E−11	SNRPF	0.08%	0.10%
rs2559850	12	102093459	A	G	0.598	0.058	0.006	6.30E−20	CHPT1	0.18%	0.16%
rs10136000	14	105253581	A	G	0.283	0.04	0.007	1.33E−08	AKT1	0.06%	0.06%
rs56738967	16	79740541	C	G	0.321	0.041	0.007	7.62E−10	MAF	0.07%	0.07%
rs9895661	17	59456589	T	C	0.817	0.063	0.008	1.05E−14	BCAS3	0.12%	0.12%

SNP single-nucleotide polymorphism, EA effect allele, NEA non-effect allele, EAF effect allele frequency, SE standard error. Beta is the regression coefficient based on the vitamin C raising allele (effect allele); R², the proportion of vitamin C variance explained by the selected genetic variants; ^a and ^b, the proportion of plasma vitamin C variance R² explained by the selected genetic variants was calculated using the first formula and the second formula

ISSN: 1865-3499