Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer’s disease

Genes & Nutrition

Table 3 GWAS summary statistics corresponding to 11 vitamin C genetic variants in IGAP and UK Biobank

SNP	Plasma vitamin C GWAS			AD GWAS from IGAP		AD proxy GWAS from UK Biobank		Maternal AD group from UK Biobank		Paternal AD group from UK Biobank		Cognitive performance GWAS
SNP	EA	NEA	EAF	Beta	6. SE	Beta	7. SE	Beta	SE	Beta	SE	Beta	SE
rs10051765	C	T	0.342	−0.0126	0.016	−0.019	0.01	−0.009	0.012	−0.036	0.017	0.00272	0.00305
rs10136000	A	G	0.283	−0.0368	0.018	0.005	0.01	−0.006	0.012	0.025	0.017	−0.00183	0.00320
rs117885456	A	G	0.087	−0.0407	0.032	−0.004	0.01	−0.004	0.012	−0.005	0.017	0.00227	0.00497
rs13028225	T	C	0.857	0.0071	0.0208	0.012	0.01	0.006	0.012	0.023	0.017	0.00557	0.00412
rs174547	C	T	0.328	−0.012	0.0151	−0.002	0.01	−0.014	0.012	0.021	0.017	0.01375	0.00300
rs2559850	A	G	0.598	−0.012	0.015	−0.011	0.01	−0.014	0.012	−0.005	0.017	−0.00145	0.00290
rs33972313	C	T	0.968	0.0144	0.0428	−0.032	0.01	−0.05	0.012	0.001	0.017	−0.00561	0.00784
rs56738967^a	C	G	0.321	0.0154	0.0166	0.006	0.01	−0.003	0.012	0.023	0.017	0.00322	0.00307
rs6693447	T	G	0.551	−0.0025	0.0148	0.01	0.01	0.007	0.012	0.015	0.017	0.00003	0.00288
rs7740812	G	A	0.594	−0.0137	0.0145	0.008	0.01	0.012	0.012	0.002	0.017	−0.00565	0.00293
rs9895661	T	C	0.817	−0.0024	0.0192	−0.014	0.01	−0.008	0.013	−0.025	0.018	−0.00288	0.00382

SNP single-nucleotide polymorphism, EA effect allele, NEA non-effect allele, EAF effect allele frequency, SE standard error. Beta is the regression coefficient based on the vitamin C raising allele (effect allele); ^awe selected the rs17689159 variant (C/T, C with the MAF = 0.29) in high linkage disequilibrium with rs56738967 (r² = 1 and D’ = 1)

ISSN: 1865-3499