Effect of AMY1 copy number variation and various doses of starch intake on glucose homeostasis: data from a cross-sectional observational study and a crossover meal study

Table 5 Postprandial responses for capillary blood glucose and plasma insulin following consumption of 40 g and 80 g starch (n = 19)

	Low AMY1 CN (n = 9)	High AMY1 CN (n = 10)	P value¹
Blood glucose, mmol/L
iAUC 40 g	125.6 (57.1)	229.7 (110.4)	0.02
iAUC 80 g	201.7 (73.8)	275.8 (138.6)	0.17
P value²	0.02	0.02
Individual differences in iAUC between 40 g and 80 g	76.0 (75.7)	46.1 (54.1)	0.33
Plasma insulin, pmol/L
iAUC 40 g	12,486 (5685)	22,056 (12,076)	0.05
iAUC 80 g	24,465 (11,235)	33,729 (22,216)	0.07
P value²	0.005	0.02
Individual differences in iAUC between 40 g and 80 g	11,979 (9246)	11,673 (13,706)	0.28

Values are presented as the mean (SD)
¹P value testing differences between AMY1 groups are determined with unpaired t tests
²P value testing differences between doses within AMY1 groups are determined with paired t tests
AMY1, salivary α-amylase gene; CN, copy number, iAUC, incremental area under the curve

ISSN: 1865-3499