Fig. 2
Heatmaps representing the top 20 GO biological processes for the comparison of insulin-resistant to insulin-sensitive individuals, for the upregulated (A) and downregulated (B) genes. Three models were used: adjusted for sex, BMI, and age (model 1); additionally adjusted for the WBC profile (model 2); and additionally adjusted for lipid and glucose-lowering medication (model 3). The GO biological processes were ranked based on their nominal p < 0.05. The color was based on the log2 fold change of the genes that were used as an input for the GO enrichment analysis; red gradients indicate upregulation and blue gradients downregulation. NA indicates that the process was not enriched