An interferon-related signature characterizes the whole blood transcriptome profile of insulin-resistant individuals—the CODAM study

Table 3 Differences in the WBC profile of the study participants, adjusted for smoking status, and lipid- and glucose-lowering medication

	Without adjustment (reference)	Smoking status	Lipid-lowering medication	Glucose-lowering medication	p Smoking status vs reference	p Lipid-lowering medication vs reference	p Glucose-lowering medication vs reference
B cells (%)	9 ± 4	9 ± 4	9 ± 4	9 ± 4	0.734	0.948	0.911
NK cells (%)	11 ± 6	11 ± 6	10 ± 6	11 ± 6	0.959	0.956	0.821
CD4T cells (%)	27 ± 12	26 ± 12	27 ± 12	27 ± 12	0.820	0.871	0.563
CD8T cells (%)	9 ± 10	10 ± 10	10 ± 10	10 ± 10	0.953	0.762	0.493
Monocytes (%)	12 ± 5	12 ± 5	12 ± 5	12 ± 5	0.814	0.956	0.736
Neutrophils (%)	27 ± 15	27 ± 15	27 ± 15	27 ± 15	0.959	0.827	0.885
Eosinophils (%)	0 ± 0	0 ± 0	0 ± 0	0 ± 0	0.753	0.810	0.781

EpiDISH was used to estimate the WBC profile from the DNA methylation data. Data are median ± MAD. P values were calculated with the Wilcoxon rank-sum test and the “without adjustment group” was used as a reference. The median eosinophil composition of 0% means very low abundance

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