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Fig. 2 | Genes & Nutrition

Fig. 2

From: Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma

Fig. 2

Overexpression of PD-L1 promoted CAL27 cell proliferation, migration, and invasion and inhibited apoptosis, while lycopene reversed the effect. A CCK-8 assay was used to measure CAL27 cell proliferation. B and C Transwell assay was carried out to measure CAL27 cells’ migratory and invasive ability. D TUNEL was used to detect CAL27 cell apoptosis. *P < 0.05 vs NC, #P < 0.05 vs CD274. NC means negative control, BC means blank control. CD274 also known as PD-L1

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