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Fig. 1 | Genes & Nutrition

Fig. 1

From: Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model

Fig. 1

Ascorbic acid (AA) supplementation reduces HFD-induced weight gain. A Experimental overview. GLUT10G128E or WT mating pairs, pregnant dams, nursing mothers, and weaned mice were supplied with drinking water supplemented with or without AA (3.3 g/L). The weaned mice were fed with normal diet (CD) for 2 weeks and then assigned to a CD or HFD from 5 to 20 weeks of age. B and C AA supplementation increases serum AA levels in mice at 3 weeks of age. Serum plasma AA levels were determined at 3 weeks of age (B) and 20 weeks of age (C) using the Ascorbic Acid Assay Kit. D and E AA supplementation reduces body weight gains in both WT and GLUT10G128E mice. D Body weights were determined at indicated ages; n = 20 mice per group. E Fasting body weight at 20 weeks of age. The data are shown as mean ± SEM. Statistical significance was determined by one-way analysis of variance (ANOVA) followed by Tukey’s test for multiple comparisons. The compact letter display indicates significant differences in pairwise comparisons; groups with different letters are significantly different

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