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Fig. 2 | Genes & Nutrition

Fig. 2

From: Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model

Fig. 2

AA supplementation rescues HFD-induced metabolic dysregulation in GLUT10G128E mice. Mice were treated as described in Fig. 1A. A HFD feeding significantly increased fasting blood glucose (FBG) levels in GLUT10G128E mice at 20 weeks of age. FBG levels were determined at the indicated time point in CD- and HFD-fed WT and GLUT10G128E mice. The data are shown as mean ± SEM. Statistical significance was determined by a two-tailed Student’s t-test. *P < 0.05. BD AA supplementation improves metabolism-related readouts in HFD-fed GLUT10G128E mice. Data were collected from mice at the conclusion of feeding (20 weeks of age). B Fasting glucose, C fasting HbA1c levels, and D fasting insulin levels. E and F AA supplementation had more pronounced effects on improving glucose tolerance and insulin sensitivity in HFD-fed GLUT10G128E mice. E Glucose tolerance test (GTT) was performed on 16-week-old mice, and F insulin tolerance test (ITT) was performed on 18-week-old animals. Right panels in E and F show the areas under the GTT and ITT curves (AUC), respectively. The AUC were calculated using GraphPad Prism 7 software. n = 4 mice per group. B–F The data are shown as mean ± SEM. Statistical significance was determined by one-way ANOVA followed by Tukey’s test for multiple comparisons. The compact letter display indicates significant differences in pairwise comparisons; groups with different letters are significantly different

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