Fig. 7From: Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative CrossDifferences in diet macronutrient composition and genetic background perturb MEs (PC1). Most module eigengene (ME) average gene expression profiles (PC1) significantly correlated with body fat % also significantly differed by diet to different degrees, as ascertained with Wilcoxon ranked-sum tests. The MEs that significantly differed by diet were A yellow (p < 0.001), B red (p < 0.01), C magenta (p < 0.001), D pink (p < 0.001), and E tan (p < 0.001), but not salmon (p > 0.1). Most module eigengene (ME) average gene expression profiles (PC1) significantly correlated with body fat % also significantly differed by CC strain to different degrees, as ascertained with Kruskal-Wallis tests. The pink and tan MEs did not differ significantly by CC strain (p > 0.07), but the MEs for the F yellow (p = 6.0 × 10−4), G red (p = 2.8 × 10−9), H magenta (p = 8.1 × 10−4), and I salmon (p = 1.3 × 10−8) modules differed significantly by CC strain. Points indicate individual calculated ME expression for each mouse, and CC strains are ordered numericallyBack to article page