Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative Cross

Table 3 Module gene composition

Module colors	BF% correlated genes	Diet DEGs	Strain DEGs	GWAS obesity traits genes	Total genes
Turquoise	564	268	2497	719	3319
Blue	108	85	499	104	716
Brown	104	80	659	142	687
Yellow	258	172	618	123	665
Green	113	30	363	71	440
Red	137	68	371	74	378
Black	75	72	263	75	345
Pink	80	102	151	43	206
Magenta	42	52	145	27	163
Purple	30	13	155	23	157
Greenyellow	27	16	102	10	107
Tan	35	33	63	20	79
Salmon	29	0	42	11	42

WCGNA identified 13 gene modules each assigned an arbitrary color with the number of genes contained in each module ranging from 42 (salmon) to 3119 (turquoise). Each gene module showed variation in terms of the number of genes with expression significantly correlated with post-diet body fat (BF%), genes differentially expressed by diet, genes differentially expressed by strain, and genes associated with obesity traits in humans according to the GWAS catalog

ISSN: 1865-3499