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Table 2 Odds ratios of low L-carnitine, choline, and betaine and rs7747752 for gestational diabetes mellitus

From: Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus

 

Multivariable model 1

Multivariable model 2

OR (95% CI)

P

OR (95% CI)

P

Metabolites

 Betaine ≤ vs. > 200 nmol/mL

6.02 (2.87–12.6)

<0.001

2.31 (0.93–5.76)

0.073

 L-carnitine ≤ vs. > 150 nmol/mL

8.27 (4.53–15.1)

<0.001

5.73 (2.96–11.1)

<0.001

 Choline

  ≤ 110 nmol/mL

4.63 (2.60–8.24)

<0.001

2.82 (1.44–5.53)

0.003

  > 110 to ≤ 270 nmol/mL

1.00

-

1.00

-

  > 270 nmol/mL

2.86 (1.18–6.94)

0.020

4.21 (1.42–12.5)

0.009

Genetic varianta

 rs7747752

  GG

1.00

-

1.00

-

  CG

1.51 (0.95–2.41)

0.080

2.06 (1.20–3.53)

0.009

  CC

2.19 (1.24–3.85)

0.007

2.99 (1.54–5.81)

0.001

  Additive (CC vs. CG vs. GG)

1.48 (1.12–1.96)

0.007

1.74 (1.25–2.42)

0.001

  Dominant (CC/CG vs. GG)

1.68 (1.08–2.62)

0.023

2.28 (1.35–3.83)

0.002

  Recessive (CC vs. CG/GG)

1.63 (1.04–2.57)

0.034

1.79 (1.06–3.00)

0.029

  1. Abbreviations: OR odds ratio, CI confidence interval
  2. Multivariable model 1, adjusted for traditional risk factors, including pre-pregnancy BMI, family history of diabetes in first-degree relatives, systolic blood pressure, current smoker before pregnancy, gestational weeks at glucose challenge test, and weight gain to the time of glucose challenge test
  3. Multivariable model 2, adjusted for choline at ≤ 110 vs. > 110 nmol/mL and ≤ 270 vs. > 270 nmol/mL, betaine ≤ 200 nmol/mL, and L-carnitine ≤ 150 nmol/mL (except for testing of its own significance), in addition to the variables listed in multivariable model 1
  4. aOnly tested its own significance and included no other variables in the multivariable model 1 and adjusted for traditional risk factors that included pre-pregnancy BMI, family history of diabetes in first-degree relatives, systolic blood pressure, current smoker before pregnancy, gestational weeks at glucose challenge test, and weight gain to the time of glucose challenge test in multivariable model 2
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Genes & Nutrition

ISSN: 1865-3499

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