Fig. 2

Three-dimensional confocal immunomicrographs of Apo B, GFAP, Iba1 and lipids. Apo B (yellow), activated astrocytes (GFAP; green) and activated microglia (Iba1; magenta) were all measured in the hippocampus of wild-type (WT) control mice and hepatic-specific-human amyloid (HSHA) mice (cell nuclei indicated in blue), with lipid inclusion bodies (LIB’s) measured in the cerebral cortex. Apolipoprotein (Apo) B, an exclusive marker of hepatic and intestinally derived lipoproteins, was measured at 8 months whilst glial fibrillar acidic protein (GFAP) GFAP, ionized calcium-binding adaptor molecule 1(Iba1) and lipids were all measured at 6 months. Apo B, GFAP and Iba1 all use same scale; white scale bar = 50 μm. LIBs of the cortex; black scale bar = 20 μm). WT, wild type; HSHA, hepatocyte-specific human amyloid; Apo B, apolipoprotein B; GFAP, glial fibrillary acidic protein; Iba1, ionized calcium-binding adaptor molecule 1; LIBs, lipid-inclusion bodies