Impairment of electron transport chain and induction of apoptosis by chrysin nanoparticles targeting succinate-ubiquinone oxidoreductase in pancreatic and lung cancer cells

Table 2 IC₅₀ of chrysin, CCNPs, CNPs, and 5-FLU on non-cancerous, A549, and PANC-1 cell lines for 48 h

IC₅₀ Concentration of treatment (μg/mL)	Cell lines
IC₅₀ Concentration of treatment (μg/mL)	Normal	A549	PANC-1
Negative control (untreated cells)	100 ± 0	100 ± 0	100 ± 0
Chrysin
mean ± SEM	129 ± 0.00849	57 ± 0.02	93 ± 0.004
*p value	p < 0.01	p < 0.01	p < 0.01
CCNPs
mean ± SEM	156 ± 0.00849	14 ± 0.014	20 ± 0.012
*p value	p < 0.01	p < 0.01	p < 0.01
5 FLU
mean ± SEM	8.07 ± 0.025	5.8 ± 0.05	2.8 ± 0. 13
*p value	p < 0.01	p < 0.01	p < 0.01
CNPs
mean ± SEM	311.1 ± 0.013	394 ± 0. 05	285 ± 0. 005
*p value	p < 0.01	p < 0.001	p < 0.0001

ISSN: 1865-3499