Fig. 7
Cell type responses in mitochondrial mass. Decreased SHMT2 leads to increased mitochondrial mass. Citrate synthase activity in A HAP1 cells and ΔSHMT2 cells and B Shmt2+/+ and Shmt2+/− MEF cells. Citrate synthase activity was normalized to total protein. Two-way ANOVA with Tukey’s post hoc analysis was used to determine media by genotype interaction and main effects of media and genotype with a statistical significance at p < 0.05. Levels not connected by the same letter are significantly different. Data represent means ± SD values, n = 4 per group with 2 embryo cells lines represented in each group. CS, citrate synthase