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Fig. 8 | Genes & Nutrition

Fig. 8

From: Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

Fig. 8

Cell type responses in NAD/NADH ratio. NAD/NADH ratio is impaired with homozygous SHMT2 loss but not heterozygous loss. NAD/NADH ratio in A HAP1 cells and ΔSHMT2 cells and B Shmt2+/+ and Shmt2+/− MEF cells. NAD/NADH ratio was normalized to total cell count. Student’s t-test was used to determine genotype effects with a statistical significance (*) at p < 0.05. Data represent means ± SD values, n = 4–8 per group with 2 embryo cells lines represented in each group for the MEF cell analyses

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Genes & Nutrition

ISSN: 1865-3499

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