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  1. The apolipoprotein E (APOE) genotype is an important risk factor for ageing and age-related diseases. The APOE4 genotype (in contrast to APOE3) has been shown to be associated with oxidative stress and chronic...

    Authors: Anne-Christin Graeser, Patricia Huebbe, Niels Storm, Wolfgang Höppner, Frank Döring, Anika E. Wagner and Gerald Rimbach
    Citation: Genes & Nutrition 2012 7:282
  2. Signal transducers and activators of transcription (STAT) proteins were described as a family of latent cytosolic transcription factors whose activation is dependent on phosphorylation via growth factor- and c...

    Authors: Anne Trécul, Franck Morceau, Mario Dicato and Marc Diederich
    Citation: Genes & Nutrition 2012 7:281
  3. Epidemiological studies have indicated a positive association between the intake of foods rich in anthocyanins and the protection against cardiovascular diseases. Some authors have shown that anthocyanins are ...

    Authors: Maria Hidalgo, Sonsoles Martin-Santamaria, Isidra Recio, Concepcion Sanchez-Moreno, Beatriz de Pascual-Teresa, Gerald Rimbach and Sonia de Pascual-Teresa
    Citation: Genes & Nutrition 2012 7:263
  4. Nonalcoholic fatty liver disease begins with a relatively benign hepatic steatosis, often associated with increased adiposity, but may progress to a more severe nonalcoholic steatohepatitis with inflammation. ...

    Authors: Kate S. Collison, Marya Z. Zaidi, Soad M. Saleh, Nadine J. Makhoul, Angela Inglis, Joey Burrows, Joseph A. Araujo and Futwan A. Al-Mohanna
    Citation: Genes & Nutrition 2011 7:261
  5. There is controversy as to the recommended daily intake of selenium (Se), and whether current New Zealand diets are adequate in this nutrient. Various functional single-nucleotide polymorphisms (SNPs) polymorp...

    Authors: Nishi Karunasinghe, Dug Yeo Han, Shuotun Zhu, Jie Yu, Katja Lange, He Duan, Roxanne Medhora, Nabitha Singh, James Kan, Waseem Alzaher, Benson Chen, Sarah Ko, Christopher M. Triggs and Lynnette R. Ferguson
    Citation: Genes & Nutrition 2011 7:259
  6. Functional polymorphisms in endogenous antioxidant defense genes including manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX-1) have been linked with risk of cancer at mul...

    Authors: Umaima Al-Alem, Peter H. Gann, Jeffrey Dahl, Richard B. van Breemen, Vilas Mistry, Patricia M. W. Lam, Mark D. Evans, Linda Van Horn and Margaret E. Wright
    Citation: Genes & Nutrition 2011 7:257
  7. Selenium (Se) is essential for human health. Despite evidence that Se intake affects inflammatory responses, the mechanisms by which Se and the selenoproteins modulate inflammatory signalling, especially in th...

    Authors: G. Gong, C. Méplan, H. Gautrey, J. Hall and J. E. Hesketh
    Citation: Genes & Nutrition 2011 7:256
  8. Consumption of trans fatty acids is positively correlated with cardiovascular diseases and with atherogenic risk factors. Trans fatty acids might play their atherogenic effects through lipid metabolism alteration...

    Authors: M. Minville-Walz, J. Gresti, L. Pichon, S. Bellenger, J. Bellenger, M. Narce and M. Rialland
    Citation: Genes & Nutrition 2011 7:258
  9. Lipoprotein lipase (LPL) polymorphism correlated with LPL activity is associated with plasma lipid and lipoprotein levels. We aimed to investigate the frequency of LPL PvuII polymorphism and effects of LPL PvuII ...

    Authors: Eunjung Shin, Na-Young Park, Yangsoo Jang, Hyunhee Oh, Jayoung Jeong, Yunsook Lim and Myoungsook Lee
    Citation: Genes & Nutrition 2011 7:251
  10. Due to protection of oncogenic proteins from degradation and enhancement of glycolytic phosphometabolites for synthetic processes, respectively, heat shock protein 90 (HSP90) and pyruvate kinase type M2 (PKM2)...

    Authors: Franziska Jahns, Anne Wilhelm, Karl Otto Greulich, Henning Mothes, Mariya Radeva, Anja Wölfert and Michael Glei
    Citation: Genes & Nutrition 2011 7:254
  11. Maternal diet during gestation can exert a long-term effect on the progeny’s health by programming their developmental scheme and metabolism. The aim of this study is to analyze the influence of maternal diet ...

    Authors: Agata Chmurzynska, Monika Stachowiak, Jan Gawecki, Ewa Pruszynska-Oszmalek and Małgorzata Tubacka
    Citation: Genes & Nutrition 2011 7:253
  12. There is a need for a tool to assess dietary intake related to the habitual dietary glycaemic index (GI) and fibre in groups with large numbers of individuals. Novel metabolite-profiling techniques may be a us...

    Authors: Lone G. Rasmussen, Hanne Winning, Francesco Savorani, Christian Ritz, Søren B. Engelsen, Arne Astrup, Thomas M. Larsen and Lars O. Dragsted
    Citation: Genes & Nutrition 2011 7:250
  13. The medicinal properties of the leaves and fruit of Olea Europaea (olive tree) have been known since antiquity. Numerous contemporary studies have linked the Mediterranean diet with increased health. In particula...

    Authors: Haloom Rafehi, Andrea J. Smith, Aneta Balcerczyk, Mark Ziemann, Jenny Ooi, Shanon J. Loveridge, Emma K. Baker, Assam El-Osta and Tom C. Karagiannis
    Citation: Genes & Nutrition 2011 7:249
  14. Changes in the inner mitochondrial membrane potential (∆ψ) may lead either to apoptosis or to protective autophagy. Connexin 43 (Cx43), a gap junction protein, is suggested to affect mitochondrial membrane per...

    Authors: Beata Kiec-Wilk, Urszula Czech, Katarzyna Janczarska, Anna Knapp, Joanna Goralska, Urszula Cialowicz, Maciej T. Malecki and Aldona Dembinska-Kiec
    Citation: Genes & Nutrition 2011 7:247
  15. Zinc (Zn) is an essential component of Zn-finger proteins and acts as a cofactor for enzymes required for cellular metabolism and in the maintenance of DNA integrity. The study investigated the genotoxic and c...

    Authors: Razinah Sharif, Philip Thomas, Peter Zalewski and Michael Fenech
    Citation: Genes & Nutrition 2011 7:248
  16. The most commonly used methods for assessing the selenium (Se) status in humans involve analysis of Se concentration, selenoprotein activity, and concentration in the blood and its compartments. Recently, it h...

    Authors: Edyta Reszka, Ewa Jablonska, Jolanta Gromadzinska and Wojciech Wasowicz
    Citation: Genes & Nutrition 2011 7:246
  17. Ginsenosides, bioactive compounds of Panax Ginseng C.A. Meyer, are divided into protopanaxadiol (PD) and protopanaxtriol (PT). The aim of this study was to evaluate the protective effects of diffe...

    Authors: Soojeong Jang, Yunsook Lim, Giuseppe Valacchi, Sungbin Sorn, Hyon Park, Na-Young Park and Myoungsook Lee
    Citation: Genes & Nutrition 2011 7:245
  18. Exacerbated production of matrix metalloproteinases (MMPs) is a key event in the progression of osteoarthritis (OA) and represents a promising target for the management of OA with nutraceuticals. In this study...

    Authors: Stefan Toegel, Shengqian Q. Wu, Miguel Otero, Mary B. Goldring, Pimporn Leelapornpisid, Catharina Chiari, Alexander Kolb, Frank M. Unger, Reinhard Windhager and Helmut Viernstein
    Citation: Genes & Nutrition 2011 7:244
  19. The essential trace mineral selenium is an important determinant of oxidative stress susceptibility, with several studies showing an inverse relationship between selenium intake and cancer. Because different c...

    Authors: Jamie L. Barger, Tsuyoshi Kayo, Thomas D. Pugh, James A. Vann, Ronan Power, Karl Dawson, Richard Weindruch and Tomas A. Prolla
    Citation: Genes & Nutrition 2011 7:243
  20. Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Identifying novel chemotherapeutic and chemopreventive approaches is critical in the prevention and treatment of can...

    Authors: Dorrelyn Patacsil, Sylvester Osayi, Anh Thu Tran, Francisco Saenz, Lydia Yimer, Ayesha N. Shajahan, Prafulla C. Gokhale, Mukesh Verma, Robert Clarke, Subhash C. Chauhan and Deepak Kumar
    Citation: Genes & Nutrition 2011 7:242
  21. It has been established beyond doubt that, as well as the liver, the small intestine is an important site of first-pass metabolism of numerous drugs, food components and toxic xenobiotics. However, there is no...

    Authors: Artur Pałasz, Anna Wiaderkiewicz, Ryszard Wiaderkiewicz, Piotr Czekaj, Beata Czajkowska, Tomasz Lebda-Wyborny, Aneta Piwowarczyk and Aleksandra Bryzek
    Citation: Genes & Nutrition 2011 7:240
  22. Maternal nutrition during gestation influences the development of the fetus, thereby determining its phenotype, including nutrient metabolism, appetite, and feeding behavior. The control of appetite is a very ...

    Authors: Agata Chmurzynska, Monika Stachowiak and Ewa Pruszynska-Oszmalek
    Citation: Genes & Nutrition 2011 7:239
  23. Although vitamin C deficiency and scurvy are generally considered as pure nutritional disorders, only a minority of the vitamin C concentration is determined by food intake. In the presence of transition metal...

    Authors: Joris R. Delanghe, Michel R. Langlois, Marc L. De Buyzere, Na Na, Jin Ouyang, Marijn M. Speeckaert and Mathieu A. Torck
    Citation: Genes & Nutrition 2011 6:237
  24. Tocotrienols (T3s), members of the vitamin E family, exhibit potent anti-cancer, anti-oxidative, anti-inflammatory, and some other biological activities. To better understand the bioavailability and metabolism...

    Authors: Zhihong Yang, Mao-Jung Lee, Yang Zhao and Chung S. Yang
    Citation: Genes & Nutrition 2011 7:233
  25. Anti-angiogenic therapy is widely being used to halt tumour angiogenesis. In this study, the anti-angiogenic activity of palm tocotrienol-rich fraction (TRF) and its individual components (γ- and δ-tocotrienol...

    Authors: Kanga Rani Selvaduray, Ammu K. Radhakrishnan, Methil Kannan Kutty and Kalanithi Nesaretnam
    Citation: Genes & Nutrition 2011 7:223
  26. Among the eight naturally occurring vitamin E analogs, γ-tocotrienol (GT3) is a particularly potent radioprophylactic agent in vivo. Moreover, GT3 protects endothelial cells from radiation injury not only by v...

    Authors: Maaike Berbée, Qiang Fu, Marjan Boerma, K. Sree Kumar, David S. Loose and Martin Hauer-Jensen
    Citation: Genes & Nutrition 2011 7:228
  27. Breast cancer is the second most frequent cancer affecting women worldwide after lung cancer. The toxicity factor associated with synthetic drugs has turned the attention toward natural compounds as the primar...

    Authors: Kalanithi Nesaretnam, Puvaneswari Meganathan, Sheela Devi Veerasenan and Kanga Rani Selvaduray
    Citation: Genes & Nutrition 2011 7:224
  28. The selective constraint of liver uptake and the sustained metabolism of tocotrienols (T3) demonstrate the need for a prompt detoxification of this class of lipophilic vitamers, and thus the potential for cyto...

    Authors: Valentina Viola, Francesca Pilolli, Marta Piroddi, Elisa Pierpaoli, Fiorenza Orlando, Mauro Provinciali, Michele Betti, Francesco Mazzini and Francesco Galli
    Citation: Genes & Nutrition 2011 7:219
  29. Encoding ribonuclease L (RNASEL) is a ubiquitously expressed latent endoribonuclease involved in the mediation of antiviral and pro-apoptotic activities of the interferon-inducible 2-5A system. Although the relat...

    Authors: Yuan-Yuan Mi, Li-Jie Zhu, Sheng Wu and Ning-Han Feng
    Citation: Genes & Nutrition 2011 6:221
  30. Cancer cells are distinguished by several distinct characteristics, such as self-sufficiency in growth signal, resistance to growth inhibition, limitless replicative potential, evasion of apoptosis, sustained ...

    Authors: Ramaswamy Kannappan, Subash C. Gupta, Ji Hye Kim and Bharat B. Aggarwal
    Citation: Genes & Nutrition 2011 7:220
  31. The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult i...

    Authors: Maria Fernanda Martínez-Salazar, Damianys Almenares-López, Sara García-Jiménez, Miguel Angel Sánchez-Alemán, Alina Juantorena-Ugás, Camilo Ríos and Antonio Monroy-Noyola
    Citation: Genes & Nutrition 2011 6:215

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