Fig. 7

Gene expression and methylation status in rat liver. Pregnant animals were fed control or low-protein diets throughout gestation [24]. A third group were fed the low-protein diet, with supplemental folate. Methylation status and gene expression were assessed in the livers of the adult offspring. Methylation of the glucocorticoid receptor (GR) gene and PPAR alpha was sensitive to maternal dietary factors and accordingly the expression of these genes was increased. PPAR gamma methylation and expression were not influenced by the maternal diet (*P < 0.05) [24]