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  1. Content type: Research

    Hepatic insulin resistance (IR) plays a crucial role in the development of many metabolic diseases, such as type 2 diabetes. MicroRNAs (miRNAs) are involved in the pathogenesis of IR and related diseases; howe...

    Authors: Xue Zhao, Zhao Chen, Zengyuan Zhou, Yuzheng Li, Yuanyuan Wang, Zihao Zhou, Huimin Lu, Changhao Sun and Xia Chu

    Citation: Genes & Nutrition 2019 14:6

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  2. Content type: Research

    The purpose of this study was to draw a global portrait of the current knowledge and interest regarding nutrigenetics in a population of French Canadians from the province of Quebec (Canada).

    Authors: Bastien Vallée Marcotte, Hubert Cormier, Véronique Garneau, Julie Robitaille, Sophie Desroches and Marie-Claude Vohl

    Citation: Genes & Nutrition 2019 14:5

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  3. Content type: Research

    Nearly 10 years ago, the World Health Organization reported the increasing prevalence of overweight and obesity worldwide as a challenge for public health due to the associated adverse consequences. Epidemiolo...

    Authors: Giuseppe Iacomino, Paola Russo, Pasquale Marena, Fabio Lauria, Antonella Venezia, Wolfgang Ahrens, Stefaan De Henauw, Pasquale De Luca, Ronja Foraita, Kathrin Günther, Lauren Lissner, Dénes Molnár, Luis A. Moreno, Michael Tornaritis, Toomas Veidebaum and Alfonso Siani

    Citation: Genes & Nutrition 2019 14:2

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  4. Content type: Commentary

    The suitability of C. elegans as a model for the question of nutritional science is a controversial topic. The discussion makes clear that C. elegans is its own best model for revealing, via genetic approaches, b...

    Authors: Dieter-Christian Gottschling and Frank Döring

    Citation: Genes & Nutrition 2019 14:1

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  5. Content type: Review

    Allium vegetables are widely consumed around the world and are known for their potential bioactive components improving human health. These effects have been extensively investigated; however, the results were in...

    Authors: Giulia Praticò, Qian Gao, Claudine Manach and Lars O. Dragsted

    Citation: Genes & Nutrition 2018 13:34

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  6. Content type: Research

    Hypovitaminosis D is prevalent worldwide. It is more prevalent in Eastern Asia region, including Korea. In addition to various environmental factors that influence serum 25-hydroxyvitamin D (25(OH)D) concentra...

    Authors: Songhwa Choi, Hyeonyoung Ko, Kayoung Lee, Joohon Sung and Yun-Mi Song

    Citation: Genes & Nutrition 2018 13:33

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  7. Content type: Research

    There is increasing evidence indicating an aberrant expression of miRNAs in colorectal cancer (CRC) development. Growing evidence has suggested that polyunsaturated fatty acids (PUFAs) could modulate the remod...

    Authors: Mostafa Moradi Sarabi, Seyed Abdollah Zahedi, Naser Pajouhi, Peyman Khosravi, Shahrokh Bagheri, Hassan Ahmadvand and Soroosh Shahryarhesami

    Citation: Genes & Nutrition 2018 13:32

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  8. Content type: Research

    Microbial communities are influenced by environmental factors including host genetics. We investigated the relationship between host bitter taste receptor genotype hTAS2R38 and oral microbiota, together with t...

    Authors: Mari A. Sandell and Maria Carmen Collado

    Citation: Genes & Nutrition 2018 13:30

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  9. Content type: Research

    Several muscle-specific microRNAs (myomiRs) are differentially expressed during cellular senescence. However, the role of dietary compounds on myomiRs remains elusive. This study aimed to elucidate the modulat...

    Authors: Azraul Mumtazah Razak, Shy Cian Khor, Faizul Jaafar, Norwahidah Abdul Karim and Suzana Makpol

    Citation: Genes & Nutrition 2018 13:31

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  10. Content type: Review

    Fruit is a key component of a healthy diet. However, it is still not clear whether some classes of fruit may be more beneficial than others and whether all individuals whatever their age, gender, health status...

    Authors: Marynka Ulaszewska, Natalia Vázquez-Manjarrez, Mar Garcia-Aloy, Rafael Llorach, Fulvio Mattivi, Lars O. Dragsted, Giulia Praticò and Claudine Manach

    Citation: Genes & Nutrition 2018 13:29

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  11. Content type: Research

    Energy homeostasis is regulated by the hypothalamus but fails when animals are fed a high-fat diet (HFD), and leptin insensitivity and obesity develops. To elucidate the possible mechanisms underlying these ef...

    Authors: Domenico Sergi, Fiona M. Campbell, Christine Grant, Amanda C. Morris, Eva-Maria Bachmair, Christiane Koch, Fiona H. McLean, Aifric Muller, Nigel Hoggard, Baukje de Roos, Begona Porteiro, Mark V. Boekschoten, Fiona C. McGillicuddy, Darcy Kahn, Phyllis Nicol, Jonas Benzler…

    Citation: Genes & Nutrition 2018 13:28

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  12. Content type: Correction

    Following publication of the original article [1], the authors reported a spelling error of the third author’s name, Mar Garcia Aloy.

    Authors: Pedapati S C Sri Harsha, Roshaida Abdul Wahab, Mar Garcia-Aloy, Francisco Madrid-Gambin, Sheila Estruel-Amades, Bernhard Watzl, Cristina Andrés-Lacueva and Lorraine Brennan

    Citation: Genes & Nutrition 2018 13:27

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    The original article was published in Genes & Nutrition 2018 13:25

  13. Content type: Review

    Dairy and egg products constitute an important part of Western diets as they represent an excellent source of high-quality proteins, vitamins, minerals and fats. Dairy and egg products are highly diverse and t...

    Authors: Linda H Münger, Mar Garcia-Aloy, Rosa Vázquez-Fresno, Doreen Gille, Albert Remus R Rosana, Anna Passerini, María-Trinidad Soria-Florido, Grégory Pimentel, Tanvir Sajed, David S Wishart, Cristina Andres Lacueva, Guy Vergères and Giulia Praticò

    Citation: Genes & Nutrition 2018 13:26

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  14. Content type: Review

    There is a growing interest in assessing dietary intake more accurately across different population groups, and biomarkers have emerged as a complementary tool to replace traditional dietary assessment methods...

    Authors: Pedapati S. C. Sri Harsha, Roshaida Abdul Wahab, Mar Garcia-Aloy, Francisco Madrid-Gambin, Sheila Estruel-Amades, Bernhard Watzl, Cristina Andrés-Lacueva and Lorraine Brennan

    Citation: Genes & Nutrition 2018 13:25

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    The Correction to this article has been published in Genes & Nutrition 2018 13:27

  15. Content type: Research

    Ninety-seven independent single nucleotide polymorphisms (SNPs) are robustly associated with adult body mass index (BMI kg/m2) in Caucasian populations. The relevance of such variants in African populations at di...

    Authors: Richard J. Munthali, Venesa Sahibdeen, Juliana Kagura, Liesl M. Hendry, Shane A. Norris, Ken K. Ong, Felix R. Day and Zané Lombard

    Citation: Genes & Nutrition 2018 13:24

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  16. Content type: Research

    Intrauterine growth-restricted (IUGR) neonates impair postnatal skeletal muscle growth. The aim of this study was to investigate whether high nutrient intake (HNI) during the suckling period could improve musc...

    Authors: Liang Hu, Fei Han, Lin Chen, Xie Peng, Daiwen Chen, De Wu, Lianqiang Che and Keying Zhang

    Citation: Genes & Nutrition 2018 13:23

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  17. Content type: Review

    To unravel true links between diet and health, it is important that dietary exposure is accurately measured. Currently, mainly self-reporting methods (e.g. food frequency questionnaires and 24-h recalls) are u...

    Authors: Charlotte C. J. R. Michielsen, Enrique Almanza-Aguilera, Elske M. Brouwer-Brolsma, Mireia Urpi-Sarda and Lydia A. Afman

    Citation: Genes & Nutrition 2018 13:22

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  18. Content type: Research

    The neurodegenerative disorder Alzheimer’s disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor fo...

    Authors: Anne Leiteritz, Benjamin Dilberger, Uwe Wenzel and Elena Fitzenberger

    Citation: Genes & Nutrition 2018 13:21

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  19. Content type: Research

    Selenium is an essential trace element and is suggested to play a role in the etiology of a number of chronic diseases. Genetic variation in genes encoding selenoproteins, such as selenoprotein P and the gluta...

    Authors: Tine Iskov Kopp, Malene Outzen, Anja Olsen, Ulla Vogel and Gitte Ravn-Haren

    Citation: Genes & Nutrition 2018 13:20

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  20. Content type: Research

    Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D3 (1,25D; active vitamin D metabolite), are proposed to play a role in the atypical social behaviors ...

    Authors: Marya S. Sabir, Mark R. Haussler, Sanchita Mallick, Ichiro Kaneko, Daniel A. Lucas, Carol A. Haussler, G. Kerr Whitfield and Peter W. Jurutka

    Citation: Genes & Nutrition 2018 13:19

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  21. Content type: Research

    Milk in mammals is a key source of lipids for offspring, providing both critical energy and essential fatty acids. For lactating sows, palmitic acid is one of the most abundant fatty acids in milk, providing 1...

    Authors: Yantao Lv, Shihai Zhang, Wutai Guan, Fang Chen, Yinzhi Zhang, Jun Chen and Yang Liu

    Citation: Genes & Nutrition 2018 13:18

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  22. Content type: Review

    Metabolic flexibility is the ability of cells to change substrates for energy production based on the nutrient availability and energy requirement. It has been shown that metabolic flexibility is impaired in o...

    Authors: Samar H. K. Tareen, Martina Kutmon, Michiel E. Adriaens, Edwin C. M. Mariman, Theo M. de Kok, Ilja C. W. Arts and Chris T. Evelo

    Citation: Genes & Nutrition 2018 13:17

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  23. Content type: Correction

    Unfortunately, after publication of this article [1], it was noticed that some corrections to Table 2 were not carried out. The corrected Table 2 can be seen below and the original article has also been update...

    Authors: Sunniva V. Larsen, Kirsten B. Holven, Inger Ottestad, Kine N. Dagsland, Mari C. W. Myhrstad and Stine M. Ulven

    Citation: Genes & Nutrition 2018 13:16

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    The original article was published in Genes & Nutrition 2018 13:9

  24. Content type: Review

    Non-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases. A wide variety of beverage constituents...

    Authors: Joseph A. Rothwell, Francisco Madrid-Gambin, Mar Garcia-Aloy, Cristina Andres-Lacueva, Caomhan Logue, Alison M. Gallagher, Carina Mack, Sabine E. Kulling, Qian Gao, Giulia Praticò, Lars O. Dragsted and Augustin Scalbert

    Citation: Genes & Nutrition 2018 13:15

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  25. Content type: Review

    Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess complia...

    Authors: L. O. Dragsted, Q. Gao, A. Scalbert, G. Vergères, M. Kolehmainen, C. Manach, L. Brennan, L. A. Afman, D. S. Wishart, C. Andres Lacueva, M. Garcia-Aloy, H. Verhagen, E. J. M. Feskens and G. Praticò

    Citation: Genes & Nutrition 2018 13:14

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  26. Content type: Research

    Both lifestyle and genetic predisposition determine the development of type 2 diabetes (T2D), and studies have indicated interactions between specific dietary components and individual genetic variants. Howeve...

    Authors: Ulrika Ericson, George Hindy, Isabel Drake, Christina-Alexandra Schulz, Louise Brunkwall, Sophie Hellstrand, Peter Almgren and Marju Orho-Melander

    Citation: Genes & Nutrition 2018 13:13

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  27. Content type: Research

    The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semant...

    Authors: Francesco Vitali, Rosario Lombardo, Damariz Rivero, Fulvio Mattivi, Pietro Franceschi, Alessandra Bordoni, Alessia Trimigno, Francesco Capozzi, Giovanni Felici, Francesco Taglino, Franco Miglietta, Nathalie De Cock, Carl Lachat, Bernard De Baets, Guy De Tré, Mariona Pinart…

    Citation: Genes & Nutrition 2018 13:12

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  28. Content type: Research

    Skeletal muscle injury activates satellite cells to initiate processes of proliferation, differentiation, and hypertrophy in order to regenerate muscle fibers. The number of microRNAs and their target genes ar...

    Authors: Karolina A. Chodkowska, Anna Ciecierska, Kinga Majchrzak, Piotr Ostaszewski and Tomasz Sadkowski

    Citation: Genes & Nutrition 2018 13:10

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  29. Content type: Research

    Solid evidence indicates that intake of marine n-3 fatty acids lowers serum triglycerides and that replacing saturated fatty acids (SFA) with polyunsaturated fatty acids (PUFA) reduces plasma total cholesterol...

    Authors: Sunniva V. Larsen, Kirsten B. Holven, Inger Ottestad, Kine N. Dagsland, Mari C. W. Myhrstad and Stine M. Ulven

    Citation: Genes & Nutrition 2018 13:9

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    The Correction to this article has been published in Genes & Nutrition 2018 13:16

  30. Content type: Research

    The presence of chemotherapy-resistant colorectal cancer stem cells (CCSCs) with KRAS mutation is thought to be one of the primary causes for treatment failure in colorectal cancer (CRC). P53, survivin, and mi...

    Authors: Mohammad Reza Sam, Mohammad Tavakoli-Mehr and Reza Safaralizadeh

    Citation: Genes & Nutrition 2018 13:8

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  31. Content type: Research

    Angiopoietin-like protein 3 (ANGPTL3), a liver-derived protein, plays an important role in the lipid and lipoprotein metabolism. Using data available from the DiOGenes study, we assessed the link with clinical...

    Authors: Anne Lundby Hess, Jérôme Carayol, Trine Blædel, Jörg Hager, Alessandro Di Cara, Arne Astrup, Wim H. M. Saris, Lesli Hingstrup Larsen and Armand Valsesia

    Citation: Genes & Nutrition 2018 13:7

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  32. Content type: Research

    Liver is the crucial organ as a hub for metabolic reactions. p16(INK4a) is a well-established cyclin-dependent kinase (CDK) inhibitor that plays important role in the molecular pathways of senescence, which le...

    Authors: Xiyuan Zhang, Guanying Bianca Xu, Dan Zhou and Yuan-Xiang Pan

    Citation: Genes & Nutrition 2018 13:6

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  33. Content type: Research

    Variation in the fat mass and obesity-associated gene (FTO) has been associated with susceptibility to obesity, but the association appears to be modified by diet. We investigated whether dietary protein intake m...

    Authors: David C. Merritt, Joseph Jamnik and Ahmed El-Sohemy

    Citation: Genes & Nutrition 2018 13:4

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  34. Content type: Review

    Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessme...

    Authors: Giulia Praticò, Qian Gao, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Sri Harsha Pedapati, Lydia A. Afman, David S. Wishart, Rosa Vázquez-Fresno, Cristina Andres-Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens and Lars O. Dragsted

    Citation: Genes & Nutrition 2018 13:3

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  35. Content type: Review

    Vitamin B12 is an essential micronutrient in humans needed for health maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and genetic factors. Evidence for the genetic basis of vit...

    Authors: S. Surendran, A. Adaikalakoteswari, P. Saravanan, I. A. Shatwaan, J. A. Lovegrove and K. S. Vimaleswaran

    Citation: Genes & Nutrition 2018 13:2

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  36. Content type: Research

    Genetic polymorphisms of antioxidant enzymes CAT, GPX, and SOD are involved in the etiology of obesity and its principal comorbidities. The aim of the present study was to analyze the effect of aforementioned ...

    Authors: César Hernández-Guerrero, Alicia Parra-Carriedo, Diana Ruiz-de-Santiago, Oscar Galicia-Castillo, Mario Buenrostro-Jáuregui and Carmen Díaz-Gutiérrez

    Citation: Genes & Nutrition 2018 13:1

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  37. Content type: Review

    Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical ap...

    Authors: Keith A. Grimaldi, Ben van Ommen, Jose M. Ordovas, Laurence D. Parnell, John C. Mathers, Igor Bendik, Lorraine Brennan, Carlos Celis-Morales, Elisa Cirillo, Hannelore Daniel, Brenda de Kok, Ahmed El-Sohemy, Susan J. Fairweather-Tait, Rosalind Fallaize, Michael Fenech, Lynnette R. Ferguson…

    Citation: Genes & Nutrition 2017 12:35

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  38. Content type: Review

    Biomarkers are an efficient means to examine intakes or exposures and their biological effects and to assess system susceptibility. Aided by novel profiling technologies, the biomarker research field is underg...

    Authors: Qian Gao, Giulia Praticò, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Lydia A. Afman, David S. Wishart, Cristina Andres-Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens and Lars O. Dragsted

    Citation: Genes & Nutrition 2017 12:34

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  39. Content type: Research

    The inverse relationship between exercise capacity and its variation over time and both cardiovascular and all-cause mortality suggests the existence of an etiological nexus between cardiometabolic diseases an...

    Authors: Natalia Gomes Gonçalves, Stephanie Heffer Cavaletti, Carlos Augusto Pasqualucci, Milton Arruda Martins and Chin Jia Lin

    Citation: Genes & Nutrition 2017 12:33

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  40. Content type: Research

    A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the “PhenFlex test” (PFT). Recently, it has been shown tha...

    Authors: T. J. van den Broek, G. C. M. Bakker, C. M. Rubingh, S. Bijlsma, J. H. M. Stroeve, B. van Ommen, M. J. van Erk and S. Wopereis

    Citation: Genes & Nutrition 2017 12:32

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  41. Content type: Research

    We investigated whether the long-term consumption of a symbiotic formulation with Lactobacillus fermentum (probiotic) and β-glucan from cauliflower mushroom (prebiotic) would delay the progression of post-menopau...

    Authors: Seong-Yeop Jeong, Suna Kang, Cao Shi Hua, Zhang Ting and Sunmin Park

    Citation: Genes & Nutrition 2017 12:31

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  42. Content type: Research

    The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in SLC30A8 is associated with an ...

    Authors: Isabel Drake, George Hindy, Ulrika Ericson and Marju Orho-Melander

    Citation: Genes & Nutrition 2017 12:30

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  43. Content type: Review

    A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with c...

    Authors: Joseph J. Castillo, Robert A. Orlando and William S. Garver

    Citation: Genes & Nutrition 2017 12:29

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  44. Content type: Research

    During evolution, humans colonized different ecological niches and adopted a variety of subsistence strategies that gave rise to diverse selective pressures acting across the genome. Environmentally induced se...

    Authors: Silvia Parolo, Sébastien Lacroix, Jim Kaput and Marie-Pier Scott-Boyer

    Citation: Genes & Nutrition 2017 12:28

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  45. Content type: Review

    Dietary supplementation of essential amino acids (EAAs) has been shown to promote healthspan. EAAs regulate, in fact, glucose and lipid metabolism and energy balance, increase mitochondrial biogenesis, and mai...

    Authors: Francesco Bifari, Chiara Ruocco, Ilaria Decimo, Guido Fumagalli, Alessandra Valerio and Enzo Nisoli

    Citation: Genes & Nutrition 2017 12:27

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  46. Content type: Review

    Obesity, a major cause of death and disability, is increasing worldwide. Obesity is characterized by a chronic, low-grade inflammatory state which is suggested to play a critical role in the development of obe...

    Authors: Vibeke H. Telle-Hansen, Jacob J. Christensen, Stine M. Ulven and Kirsten B. Holven

    Citation: Genes & Nutrition 2017 12:26

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