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  1. Glycogen storage disease type Ia (GSDIa) is an inborn metabolic disorder caused by the deficiency of glucose-6-phospatase-α (G6Pase-α) leading to mitochondrial dysfunction. It remains unclear whether mitochond...

    Authors: Alessandro Rossi, Antonia Assunto, Carmen Rosano, Sara Tucci, Margherita Ruoppolo, Marianna Caterino, Francesca Pirozzi, Pietro Strisciuglio, Giancarlo Parenti and Daniela Melis
    Citation: Genes & Nutrition 2023 18:10
    Content type: Research Published on:

  4. The predominant source of alcohol in the diet is alcoholic beverages, including beer, wine, spirits and liquors, sweet wine, and ciders. Self-reported alcohol intakes are likely to be influenced by measurement...

    Authors: Marta Trius-Soler, Giulia Praticò, Gözde Gürdeniz, Mar Garcia-Aloy, Raffaella Canali, Natella Fausta, Elske M. Brouwer-Brolsma, Cristina Andrés-Lacueva and Lars Ove Dragsted
    Citation: Genes & Nutrition 2023 18:7
    Content type: Review Published on:

    The Correction to this article has been published in Genes & Nutrition 2023 18:9

  5. FOXO has long been associated with aging, exercise, and tissue homeostasis, but it remains unclear what the role is of the muscle FOXO gene in E against high-salt intake(HSI)-induced age-related defects of the...

    Authors: Deng-tai Wen, Ying-hui Gao, Jingfeng Wang, Shijie Wang, Qi Zhong and Wen-qi Hou
    Citation: Genes & Nutrition 2023 18:6
    Content type: Research Published on:

  6. Serine hydroxymethyltransferase 2 (SHMT2) catalyzes the reversible conversion of tetrahydrofolate (THF) and serine-producing THF-conjugated one-carbon units and glycine in the mitochondria. Biallelic SHMT2 varian...

    Authors: Joanna L. Fiddler, Jamie E. Blum, Katarina E. Heyden, Luisa F. Castillo, Anna E. Thalacker-Mercer and Martha S. Field
    Citation: Genes & Nutrition 2023 18:5
    Content type: Research Published on:

  7. Flavonoids may help ameliorate the incidence of the major causes of tumor-related mortality, such as pancreatic ductal adenocarcinoma (PDAC) and lung cancer, which are predicted to steadily increase between 20...

    Authors: Eman M. Ragab, Doaa M. El Gamal, Tarek M. Mohamed and Abeer A. Khamis
    Citation: Genes & Nutrition 2023 18:4
    Content type: Research Published on:

  8. Metabotyping is a novel concept to group metabolically similar individuals. Different metabotypes may respond differently to dietary interventions; hence, metabotyping may become an important future tool in pr...

    Authors: Amanda Rundblad, Jacob J. Christensen, Kristin S. Hustad, Nasser E. Bastani, Inger Ottestad, Kirsten B. Holven and Stine M. Ulven
    Citation: Genes & Nutrition 2023 18:3
    Content type: Research Published on:

  9. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by brain parenchymal abundance of amyloid-beta (Aβ) and the accumulation of lipofuscin material that is rich in...

    Authors: Zachary J. D’Alonzo, Virginie Lam, Ryu Takechi, Michael Nesbit, Mauro Vaccarezza and John C. L. Mamo
    Citation: Genes & Nutrition 2023 18:2
    Content type: Review Published on:

  10. Authors: Sahar Cheshmeh, Negin Elahi, Maysa Ghayyem, Elaheh Mosaieby, Shima Moradi, Yahya Pasdar, Susan Tahmasebi and Mehdi Moradinazar
    Citation: Genes & Nutrition 2023 18:1
    Content type: Correction Published on:

    The original article was published in Genes & Nutrition 2022 17:17

  11. Polycystic ovary syndrome (PCOS) is an endocrine disease in which related to obesity, metabolic disorders and is considered as one of the main causes of infertility in women. This trial was investigated the ef...

    Authors: Sahar Cheshmeh, Negin Elahi, Maysa Ghayyem, Elaheh Mosaieby, Shima Moradi, Yahya Pasdar, Susan Tahmasebi and Mehdi Moradinazar
    Citation: Genes & Nutrition 2022 17:17
    Content type: Research Published on:

    The Correction to this article has been published in Genes & Nutrition 2023 18:1

  13. Prebiotic/probiotic supplementation represents a viable option for addressing elevated systemic inflammation and chronic disease risk in overweight individuals. The purpose of this study was to determine if 90...

    Authors: Brian K. McFarlin, Elizabeth A. Tanner, David W. Hill and Jakob L. Vingren
    Citation: Genes & Nutrition 2022 17:15
    Content type: Research Published on:

  14. Interactions between genetic, metabolic, and environmental factors lead to gestational diabetes mellitus (GDM). We aimed to examine interactive effects of cyclin-dependent kinase 5 regulatory subunit-associate...

    Authors: Hui Wang, Jing Li, Jinnan Liu, Junhong Leng, Weiqin Li, Zhijie Yu, Claudia H. T. Tam, Gang Hu, Ronald C. W. Ma, Zhongze Fang, Ying Wang and Xilin Yang
    Citation: Genes & Nutrition 2022 17:14
    Content type: Research Published on:

  15. Obesity is a serious disease with a complex etiology characterized by overaccumulation of adiposity resulting in detrimental health outcomes. Given the liver’s critical role in the biological processes that at...

    Authors: Phoebe Yam, Melissa VerHague, Jody Albright, Erik Gertz, Fernando Pardo-Manuel de Villena and Brian J. Bennett
    Citation: Genes & Nutrition 2022 17:13
    Content type: Research Published on:

  16. Phenylthiocarbamide (PTC) sensitivity, a sensory trait mediated by the bitter taste receptor 38 (TAS2R38), has been described as a promising biomarker of health status or disease risk. The aim of this cross-se...

    Authors: Marta Trius-Soler, Paz A. Bersano-Reyes, Clara Góngora, Rosa M. Lamuela-Raventós, Gema Nieto and Juan J. Moreno
    Citation: Genes & Nutrition 2022 17:12
    Content type: Research Published on:

  17. MicroRNAs (miRNAs) targeting has been revealed to be an appealing strategy for the treatment and management of atrial fibrillation (AF). In this research, we aimed to explore the mechanisms of miR-205-5p in re...

    Authors: Zezhou Xiao, Yu Xie, Fangze Huang, Jie Yang, Ximao Liu, Xuefeng Lin, Peng Zhu and Shaoyi Zheng
    Citation: Genes & Nutrition 2022 17:11
    Content type: Research Published on:

  18. The development of type 2 diabetes mellitus (T2DM) is highly influenced by complex interactions between genetic and environmental (dietary and lifestyle) factors. While vitamin C (ascorbic acid, AA) has been s...

    Authors: Chung-Lin Jiang, Chang-Yu Tsao and Yi-Ching Lee
    Citation: Genes & Nutrition 2022 17:10
    Content type: Research Published on:

  19. We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-t...

    Authors: Bruno Rafael Virginio de Sousa, Lydiane de Lima Tavares Toscano, Eder Jackson Bezerra de Almeida Filho, Klécia Farias Sena, Matheus Silveira Costa, Rebeka Correia de Souza Cunha, Jullyana de Souza Siqueira Quintans, Luana Heimfarth, Aline Telles Biasoto Marques, Darcilene Fiuza da Silva, Luis Felipe Castelli Correia de Campos, Darlene Camati Persuhn and Alexandre Sérgio Silva
    Citation: Genes & Nutrition 2022 17:9
    Content type: Research Published on:

  21. Early life vitamin D exposure is linked to later skeletal health with maternal vitamin D status in pregnancy associated with neonatal bone mass. The MAVIDOS study has demonstrated that vitamin D supplementatio...

    Authors: Nevena Krstic, Nick Bishop, Beth Curtis, Cyrus Cooper, Nick Harvey, Karen Lilycrop, Robert Murray, Robert Owen, Gwen Reilly, Tim Skerry and Steph Borg
    Citation: Genes & Nutrition 2022 17:7
    Content type: Research Published on:

  22. Genetic instability leads to genome mutations, changes in nucleotide sequences, rearrangements, and gains or losses of part of the chromosomes. This instability can initiate and develop cancer. This study eval...

    Authors: Abeer A. Khamis, Rana M. Ibrahim, Gad B. El-hefnawy, Wafaa M. Ibrahim and Ehab M. Ali
    Citation: Genes & Nutrition 2022 17:6
    Content type: Research Published on:

  23. Metabolic syndrome (MetS) is characterized by the coexistence of disorders such as diabetes, hypertension, hyperlipidemia, and obesity and is affected by genetic factors. Previous genome-wide association studi...

    Authors: Woo Jeong Choi and Dayeon Shin
    Citation: Genes & Nutrition 2022 17:5
    Content type: Research Published on:

  25. Cancer therapy targeting programmed death receptor-1 (PD-1 or CD279) or programmed death-ligand 1 (PD-L1 or CD274) gives hope to Tongue Squamous Cell Carcinoma (TSCC) treatment. However, the tumor-intrinsic me...

    Authors: Mingjing Peng, Songqing Fan, Junjun Li, Xiao Zhou, Qianjin Liao, Faqing Tang and Wei Liu
    Citation: Genes & Nutrition 2022 17:3
    Content type: Research Published on:

  26. Previous observational studies have demonstrated inconsistent and inconclusive results of changes in the intestinal microbiota in patients with obesity and metabolic disorders. We performed a systematic review...

    Authors: Zhilu XU, Wei JIANG, Wenli HUANG, Yu LIN, Francis K.L. CHAN and Siew C. NG
    Citation: Genes & Nutrition 2022 17:2
    Content type: Review Published on:

  27. Vitamin D (Vit-D) promotes vascular repair and its deficiency is closely linked to the development of type 2 diabetes mellitus (T2DM) and hypertension. Whether genetially predicted vitamin D status (serologica...

    Authors: Yap-Hang Chan, C. Mary Schooling, Jie V. Zhao, Shiu-Lun Au Yeung, Jo Jo Hai, G. Neil Thomas, Kar-Keung Cheng, Chao-Qiang Jiang, Yuen-Kwun Wong, Ka-Wing Au, Clara S. Tang, Chloe Y. Y. Cheung, Aimin Xu, Pak-Chung Sham, Tai-Hing Lam, Karen Siu-Ling Lam…
    Citation: Genes & Nutrition 2022 17:1
    Content type: Research Published on:

  28. Worldwide, the prevalence of obesity and insulin resistance has grown dramatically. Gene expression profiling in blood represents a powerful means to explore disease pathogenesis, but the potential impact of i...

    Authors: Marianthi Kalafati, Martina Kutmon, Chris T. Evelo, Carla J. H. van der Kallen, Casper G. Schalkwijk, Coen D. A. Stehouwer, B. I. O. S. Consortium, Ellen E. Blaak, Marleen M. J. van Greevenbroek and Michiel Adriaens
    Citation: Genes & Nutrition 2021 16:22
    Content type: Research Published on:

  29. Copy number (CN) variation (CNV) of the salivary amylase gene (AMY1) influences the ability to digest starch and may influence glucose homeostasis, obesity and gut microbiota composition. Hence, the aim was to ex...

    Authors: Mary Farrell, Stina Ramne, Phébée Gouinguenet, Louise Brunkwall, Ulrika Ericson, Anne Raben, Peter M. Nilsson, Marju Orho-Melander, Yvonne Granfeldt, Juscelino Tovar and Emily Sonestedt
    Citation: Genes & Nutrition 2021 16:21
    Content type: Research Published on:

  30. Circulating branched chain amino acids (BCAAs) increase the risk of type 2 diabetes (T2D). The genetic variants in the BCAA metabolic pathway influence the individual metabolic ability of BCAAs and may affect ...

    Authors: Weiqi Wang, Zengjiao Liu, Lin Liu, Tianshu Han, Xue Yang and Changhao Sun
    Citation: Genes & Nutrition 2021 16:20
    Content type: Research Published on:

  31. Until now, observational studies have explored the impact of vitamin C intake on Alzheimer’s disease (AD) risk, however, reported ambiguous findings. To develop effective therapies or prevention, the causal li...

    Authors: Haijie Liu, Yan Zhang, Yang Hu, Haihua Zhang, Tao Wang, Zhifa Han, Shan Gao, Longcai Wang and Guiyou Liu
    Citation: Genes & Nutrition 2021 16:19
    Content type: Research Published on:

  33. Quantitative real-time polymerase chain reaction (qPCR) is a reliable and efficient method for quantitation of gene expression. Due to the increased use of qPCR in examining nutrient-gene interactions, it is i...

    Authors: Joanna L. Fiddler and Stephen L. Clarke
    Citation: Genes & Nutrition 2021 16:17
    Content type: Research Published on:

  34. Nutrient composition of vegetarian diets is greatly different from that of omnivore diets, which may fundamentally influence the gut microbiota and fecal metabolites. The interactions between diet pattern and ...

    Authors: Xinqi Deng, Jiangtao Si, Yonglong Qu, Li Jie, Yuansong He, Chunguo Wang and Yuping Zhang
    Citation: Genes & Nutrition 2021 16:16
    Content type: Research Published on:

  35. Vitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies. Inconsistencies among findings may be explained by unaccounted genetic ...

    Authors: Alicia C. Jarosz, Daniel Noori, Tara Zeitoun, Bibiana Garcia-Bailo and Ahmed El-Sohemy
    Citation: Genes & Nutrition 2021 16:15
    Content type: Research Published on:

    The Correction to this article has been published in Genes & Nutrition 2021 16:18

  36. Given the key role of methionine (Met) in biological processes like protein translation, methylation, and antioxidant defense, inadequate Met supply can limit performance. This study investigated the effect of...

    Authors: Stella Romanet, Jörg R. Aschenbach, Robert Pieper, Jürgen Zentek, John K. Htoo, Rose A. Whelan and Lucia Mastrototaro
    Citation: Genes & Nutrition 2021 16:14
    Content type: Research Published on:

  37. It is reported that circular RNAs (circRNAs) play a key role in atherosclerosis (AS). Foam cell formation, which is the main feature of AS, can be significantly inhibited by cholesterol efflux.

    Authors: Jie Liu, Yue Wei, Yong Lin, Peiwen Zhang, Zhexiao Zhang, Hairong Huang, Hongfu Wu and Tangbin Zou
    Citation: Genes & Nutrition 2021 16:13
    Content type: Research Published on:

  38. Peripheral blood mononuclear cells (PBMCs) have shown promise as a tissue sensitive to subtle and possibly systemic transcriptomic changes, and as such may be useful in identifying responses to weight loss int...

    Authors: Kaitlin Day, Aimee L. Dordevic, Helen Truby, Melissa C. Southey, Susan Coort and Chiara Murgia
    Citation: Genes & Nutrition 2021 16:12
    Content type: Review Published on:

  40. In recent years, the exciting emergence of circulating miRNAs as stable, reproducible, and consistent among individuals has opened a promising research opportunity for the detection of non-invasive biomarkers....

    Authors: Giuseppe Iacomino, Fabio Lauria, Paola Russo, Antonella Venezia, Nunzia Iannaccone, Pasquale Marena, Wolfgang Ahrens, Stefaan De Henauw, Dénes Molnár, Gabriele Eiben, Ronja Foraita, Antje Hebestreit, Giannis Kourides, Luis A. Moreno, Toomas Veidebaum and Alfonso Siani
    Citation: Genes & Nutrition 2021 16:10
    Content type: Research Published on:

  41. Previous observational studies have provided conflicting results on the association between serum iron status and the risk of breast cancer. Considering the relevance of this relationship to breast cancer prev...

    Authors: Chenyang Hou, Qingzhi Hou, Xing Xie, Huifeng Wang, Yueliang Chen, Tingxi Lu, Qunying Wu, Yongcong Liang, Yanling Hu and Yuang Mao
    Citation: Genes & Nutrition 2021 16:9
    Content type: Research Published on:

  42. Chronic exposure of pancreatic β cells to high levels of stearic acid (C18:0) leads to impaired insulin secretion, which accelerates the progression of type 2 diabetes mellitus (T2DM). Recently, long noncoding...

    Authors: Rui Guo, Yunjin Zhang, Yue Yu, Shenghan Su, Qingrui Zhao, Xia Chu, Shenglong Li, Huimin Lu✉ and Changhao Sun
    Citation: Genes & Nutrition 2021 16:8
    Content type: Research Published on:

    The Correction to this article has been published in Genes & Nutrition 2021 16:11

  43. Blueberries contain high levels of polyphenolic compounds with high in vitro antioxidant capacities. Their consumption has been associated with improved vascular and metabolic health.

    Authors: Michèle Rousseau, Justine Horne, Frédéric Guénard, Juan de Toro-Martín, Véronique Garneau, Valérie Guay, Michèle Kearney, Geneviève Pilon, Denis Roy, Patrick Couture, Charles Couillard, André Marette and Marie-Claude Vohl
    Citation: Genes & Nutrition 2021 16:7
    Content type: Research Published on:

  44. This study aimed to evaluate the association of single nucleotide polymorphisms (SNPs) of vitamin D metabolic pathway genes with susceptibility to pulmonary tuberculosis (PTB).

    Authors: Tian-Ping Zhang, Shuang-Shuang Chen, Gen-You Zhang, Si-Jiu Shi, Li Wei and Hong-Miao Li
    Citation: Genes & Nutrition 2021 16:6
    Content type: Research Published on:

  45. Fermented foods are ubiquitous in human diets and often lauded for their sensory, nutritious, and health-promoting qualities. However, precise associations between the intake of fermented foods and health have...

    Authors: Katherine J. Li, Elske M. Brouwer-Brolsma, Kathryn J. Burton-Pimentel, Guy Vergères and Edith J. M. Feskens
    Citation: Genes & Nutrition 2021 16:5
    Content type: Review Published on:

  46. Previous studies have found the important gene-diet interactions on type 2 diabetes (T2D) incident but have not followed branched-chain amino acids (BCAAs), even though they have shown heterogeneous effectiven...

    Authors: Weiqi Wang, Haiyang Jiang, Ziwei Zhang, Wei Duan, Tianshu Han and Changhao Sun
    Citation: Genes & Nutrition 2021 16:4
    Content type: Research Published on:

  47. Despite the increasing number of personalized nutrition services available on the market, nutrigenomics-based level of personalization is still the exception rather than a mainstream activity. This can be part...

    Authors: Zoltán Szakály, Bence Kovács, Márk Szakály, Dorka T. Nagy-Pető, Péter Popovics and Marietta Kiss
    Citation: Genes & Nutrition 2021 16:3
    Content type: Research Published on:

  49. Periconceptional folic acid (FA) supplementation not only reduces the incidence of neural tube defects, but also improves cognitive performances in offspring. However, the genes or pathways that are epigenetic...

    Authors: Xinyan Wang, Zhenshu Li, Yun Zhu, Jing Yan, Huan Liu, Guowei Huang and Wen Li
    Citation: Genes & Nutrition 2021 16:1
    Content type: Research Published on:

  50. Increased adipogenesis and altered adipocyte function contribute to the development of obesity and associated comorbidities. Fructose modified adipocyte metabolism compared to glucose, but the regulatory mecha...

    Authors: Giulia Tini, Vijayalakshmi Varma, Rosario Lombardo, Greg T. Nolen, Gregory Lefebvre, Patrick Descombes, Sylviane Métairon, Corrado Priami, Jim Kaput and Marie-Pier Scott-Boyer
    Citation: Genes & Nutrition 2020 15:21
    Content type: Research Published on:
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Genes & Nutrition

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