Genes & Nutrition is affiliated with the European Nutrigenomics Organisation (NuGO). NuGO is an association of universities and research institutes focusing on the joint development of the research area of molecular nutrition, personalized nutrition, nutrigenomics and nutritional systems biology.
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Citation: Genes & Nutrition 2023 18:1
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Effect of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with polycystic ovary syndrome: a double blind randomized controlled trial
Polycystic ovary syndrome (PCOS) is an endocrine disease in which related to obesity, metabolic disorders and is considered as one of the main causes of infertility in women. This trial was investigated the ef...
Citation: Genes & Nutrition 2022 17:17 -
Comparison of apical and basolateral Cu treatment for iron-related gene regulation during deferoxamine induced iron deficiency
Intestinal copper transporter (Atp7a) mutant-brindled mice with systemic Cu deficiency had elevated Cu levels in enterocyte cells without any perturbation of iron-regulating genes, suggesting that blood Cu lev...
Citation: Genes & Nutrition 2022 17:16 -
Prebiotic/probiotic supplementation resulted in reduced visceral fat and mRNA expression associated with adipose tissue inflammation, systemic inflammation, and chronic disease risk
Prebiotic/probiotic supplementation represents a viable option for addressing elevated systemic inflammation and chronic disease risk in overweight individuals. The purpose of this study was to determine if 90...
Citation: Genes & Nutrition 2022 17:15 -
Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus
Interactions between genetic, metabolic, and environmental factors lead to gestational diabetes mellitus (GDM). We aimed to examine interactive effects of cyclin-dependent kinase 5 regulatory subunit-associate...
Citation: Genes & Nutrition 2022 17:14 -
Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative Cross
Obesity is a serious disease with a complex etiology characterized by overaccumulation of adiposity resulting in detrimental health outcomes. Given the liver’s critical role in the biological processes that at...
Citation: Genes & Nutrition 2022 17:13 -
Association of phenylthiocarbamide perception with anthropometric variables and intake and liking for bitter vegetables
Phenylthiocarbamide (PTC) sensitivity, a sensory trait mediated by the bitter taste receptor 38 (TAS2R38), has been described as a promising biomarker of health status or disease risk. The aim of this cross-se...
Citation: Genes & Nutrition 2022 17:12 -
MicroRNA-205-5p plays a suppressive role in the high-fat diet-induced atrial fibrosis through regulation of the EHMT2/IGFBP3 axis
MicroRNAs (miRNAs) targeting has been revealed to be an appealing strategy for the treatment and management of atrial fibrillation (AF). In this research, we aimed to explore the mechanisms of miR-205-5p in re...
Citation: Genes & Nutrition 2022 17:11 -
Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model
The development of type 2 diabetes mellitus (T2DM) is highly influenced by complex interactions between genetic and environmental (dietary and lifestyle) factors. While vitamin C (ascorbic acid, AA) has been s...
Citation: Genes & Nutrition 2022 17:10 -
Purple grape juice improves performance of recreational runners, but the effect is genotype dependent: a double blind, randomized, controlled trial
We examined the influence of superoxide dismutase 3 (SOD3) Arg213Gly and Peroxisome Proliferator-Activated α-Receptor (PPARα) 7G/C polymorphisms to a single dose of purple grape juice supplementation on time-t...
Citation: Genes & Nutrition 2022 17:9 -
Genetic support of a causal relationship between iron status and atrial fibrillation: a Mendelian randomization study
Atrial fibrillation is the most common arrhythmia disease. Animal and observational studies have found a link between iron status and atrial fibrillation. However, the causal relationship between iron status a...
Citation: Genes & Nutrition 2022 17:8 -
Early life vitamin D depletion and mechanical loading determine methylation changes in the RUNX2, RXRA, and osterix promoters in mice
Early life vitamin D exposure is linked to later skeletal health with maternal vitamin D status in pregnancy associated with neonatal bone mass. The MAVIDOS study has demonstrated that vitamin D supplementatio...
Citation: Genes & Nutrition 2022 17:7 -
Impact of anthocyanin on genetic stability in mammary adenocarcinoma-induced mice treated with methotrexate
Genetic instability leads to genome mutations, changes in nucleotide sequences, rearrangements, and gains or losses of part of the chromosomes. This instability can initiate and develop cancer. This study eval...
Citation: Genes & Nutrition 2022 17:6 -
Interactions between red and processed meat consumption and APOA5 gene variants associated with the incidence of metabolic syndrome in Korean adults
Metabolic syndrome (MetS) is characterized by the coexistence of disorders such as diabetes, hypertension, hyperlipidemia, and obesity and is affected by genetic factors. Previous genome-wide association studi...
Citation: Genes & Nutrition 2022 17:5 -
Genistein protects against ultraviolet B–induced wrinkling and photoinflammation in in vitro and in vivo models
Chronic exposure to ultraviolet (UV) rays causes severe skin damage by inducing oxidative stress and inflammation. Identifying a safe and natural substance for skin protection is a crucial research goal.
Citation: Genes & Nutrition 2022 17:4 -
Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma
Cancer therapy targeting programmed death receptor-1 (PD-1 or CD279) or programmed death-ligand 1 (PD-L1 or CD274) gives hope to Tongue Squamous Cell Carcinoma (TSCC) treatment. However, the tumor-intrinsic me...
Citation: Genes & Nutrition 2022 17:3 -
Gut microbiota in patients with obesity and metabolic disorders — a systematic review
Previous observational studies have demonstrated inconsistent and inconclusive results of changes in the intestinal microbiota in patients with obesity and metabolic disorders. We performed a systematic review...
Citation: Genes & Nutrition 2022 17:2 -
Mendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control
Vitamin D (Vit-D) promotes vascular repair and its deficiency is closely linked to the development of type 2 diabetes mellitus (T2DM) and hypertension. Whether genetially predicted vitamin D status (serologica...
Citation: Genes & Nutrition 2022 17:1 -
An interferon-related signature characterizes the whole blood transcriptome profile of insulin-resistant individuals—the CODAM study
Worldwide, the prevalence of obesity and insulin resistance has grown dramatically. Gene expression profiling in blood represents a powerful means to explore disease pathogenesis, but the potential impact of i...
Citation: Genes & Nutrition 2021 16:22 -
Effect of AMY1 copy number variation and various doses of starch intake on glucose homeostasis: data from a cross-sectional observational study and a crossover meal study
Copy number (CN) variation (CNV) of the salivary amylase gene (AMY1) influences the ability to digest starch and may influence glucose homeostasis, obesity and gut microbiota composition. Hence, the aim was to ex...
Citation: Genes & Nutrition 2021 16:21 -
Genetic predisposition to impaired metabolism of the branched chain amino acids, dietary intakes, and risk of type 2 diabetes
Circulating branched chain amino acids (BCAAs) increase the risk of type 2 diabetes (T2D). The genetic variants in the BCAA metabolic pathway influence the individual metabolic ability of BCAAs and may affect ...
Citation: Genes & Nutrition 2021 16:20 -
Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer’s disease
Until now, observational studies have explored the impact of vitamin C intake on Alzheimer’s disease (AD) risk, however, reported ambiguous findings. To develop effective therapies or prevention, the causal li...
Citation: Genes & Nutrition 2021 16:19 -
Correction to: Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms
Citation: Genes & Nutrition 2021 16:18 -
Evaluation of candidate reference genes for quantitative real-time PCR analysis in a male rat model of dietary iron deficiency
Quantitative real-time polymerase chain reaction (qPCR) is a reliable and efficient method for quantitation of gene expression. Due to the increased use of qPCR in examining nutrient-gene interactions, it is i...
Citation: Genes & Nutrition 2021 16:17 -
Vegetarian diet duration’s influence on women’s gut environment
Nutrient composition of vegetarian diets is greatly different from that of omnivore diets, which may fundamentally influence the gut microbiota and fecal metabolites. The interactions between diet pattern and ...
Citation: Genes & Nutrition 2021 16:16 -
Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms
Vitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies. Inconsistencies among findings may be explained by unaccounted genetic ...
Citation: Genes & Nutrition 2021 16:15 -
Expression of proposed methionine transporters along the gastrointestinal tract of pigs and their regulation by dietary methionine sources
Given the key role of methionine (Met) in biological processes like protein translation, methylation, and antioxidant defense, inadequate Met supply can limit performance. This study investigated the effect of...
Citation: Genes & Nutrition 2021 16:14 -
Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq
It is reported that circular RNAs (circRNAs) play a key role in atherosclerosis (AS). Foam cell formation, which is the main feature of AS, can be significantly inhibited by cholesterol efflux.
Citation: Genes & Nutrition 2021 16:13 -
Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesis
Peripheral blood mononuclear cells (PBMCs) have shown promise as a tissue sensitive to subtle and possibly systemic transcriptomic changes, and as such may be useful in identifying responses to weight loss int...
Citation: Genes & Nutrition 2021 16:12 -
Correction to: TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis
Citation: Genes & Nutrition 2021 16:11 -
The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study
In recent years, the exciting emergence of circulating miRNAs as stable, reproducible, and consistent among individuals has opened a promising research opportunity for the detection of non-invasive biomarkers....
Citation: Genes & Nutrition 2021 16:10 -
Serum iron status and the risk of breast cancer in the European population: a two-sample Mendelian randomisation study
Previous observational studies have provided conflicting results on the association between serum iron status and the risk of breast cancer. Considering the relevance of this relationship to breast cancer prev...
Citation: Genes & Nutrition 2021 16:9 -
TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis
Chronic exposure of pancreatic β cells to high levels of stearic acid (C18:0) leads to impaired insulin secretion, which accelerates the progression of type 2 diabetes mellitus (T2DM). Recently, long noncoding...
Citation: Genes & Nutrition 2021 16:8 -
An 8-week freeze-dried blueberry supplement impacts immune-related pathways: a randomized, double-blind placebo-controlled trial
Blueberries contain high levels of polyphenolic compounds with high in vitro antioxidant capacities. Their consumption has been associated with improved vascular and metabolic health.
Citation: Genes & Nutrition 2021 16:7 -
Association of vitamin D pathway genes polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population
This study aimed to evaluate the association of single nucleotide polymorphisms (SNPs) of vitamin D metabolic pathway genes with susceptibility to pulmonary tuberculosis (PTB).
Citation: Genes & Nutrition 2021 16:6 -
A systematic review to identify biomarkers of intake for fermented food products
Fermented foods are ubiquitous in human diets and often lauded for their sensory, nutritious, and health-promoting qualities. However, precise associations between the intake of fermented foods and health have...
Citation: Genes & Nutrition 2021 16:5 -
Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese
Previous studies have found the important gene-diet interactions on type 2 diabetes (T2D) incident but have not followed branched-chain amino acids (BCAAs), even though they have shown heterogeneous effectiven...
Citation: Genes & Nutrition 2021 16:4 -
Consumer acceptance of genetic-based personalized nutrition in Hungary
Despite the increasing number of personalized nutrition services available on the market, nutrigenomics-based level of personalization is still the exception rather than a mainstream activity. This can be part...
Citation: Genes & Nutrition 2021 16:3 -
Will guidelines on alcohol consumption be personalized by a genetic approach?
Citation: Genes & Nutrition 2021 16:2 -
Maternal folic acid impacts DNA methylation profile in male rat offspring implicated in neurodevelopment and learning/memory abilities
Periconceptional folic acid (FA) supplementation not only reduces the incidence of neural tube defects, but also improves cognitive performances in offspring. However, the genes or pathways that are epigenetic...
Citation: Genes & Nutrition 2021 16:1 -
DNA methylation during human adipogenesis and the impact of fructose
Increased adipogenesis and altered adipocyte function contribute to the development of obesity and associated comorbidities. Fructose modified adipocyte metabolism compared to glucose, but the regulatory mecha...
Citation: Genes & Nutrition 2020 15:21 -
Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies
This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women.
Citation: Genes & Nutrition 2020 15:20 -
Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian
Cardiometabolic diseases are complex traits which are influenced by several single nucleotide polymorphisms (SNPs). Thus, analysing the combined effects of multiple gene variants might provide a better underst...
Citation: Genes & Nutrition 2020 15:19 -
Moderately high folate level may offset the effects of aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and precancerous lesions
This study evaluated gene-nutrition interactions between folate and the aberrant DNA methylation of tumor suppressor genes in different stages of carcinogenesis of esophageal squamous cell carcinoma (ESCC).
Citation: Genes & Nutrition 2020 15:18 -
Food intake biomarkers for berries and grapes
Grapes and berries are two types of widely consumed fruits characterized by a high content in different phytochemicals. However, their accurate dietary assessment is particularly arduous, because of the alread...
Citation: Genes & Nutrition 2020 15:17 -
Predictors of stakeholders’ intention to adopt nutrigenomics
Nutrigenomics is an emerging science that studies the relationship between genes, diet and nutrients that can help prevent chronic disease. The development of this science depends on whether the public accept ...
Citation: Genes & Nutrition 2020 15:16 -
Low-grade chronic inflammation is attenuated by exercise training in obese adults through down-regulation of ASC gene in peripheral blood: a pilot study
Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associat...
Citation: Genes & Nutrition 2020 15:15 -
Testosterone deficiency caused by castration increases adiposity in male rats in a tissue-specific and diet-dependent manner
Testosterone deficiency in men is clinically associated with the development of metabolic syndrome, which manifests as obesity, hepatic steatosis, and type-2 diabetes. We investigated the effects of castration...
Citation: Genes & Nutrition 2020 15:14 -
Melanocortin-4 receptor (MC4R) rs17782313 polymorphism interacts with Dietary Approach to Stop Hypertension (DASH) and Mediterranean Dietary Score (MDS) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals
The association with obesity of a common variant near the melanocortin-4 receptor (MC4R) gene (rs17782313) has been indicated in various studies. Adherence to dietary quality indices also have shown to have po...
Citation: Genes & Nutrition 2020 15:13 -
Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice
Adiponectin and resistin are typically secreted by the adipose tissue and are abnormally expressed in obesity. However, the underlying influential factors and mechanisms are to be elucidated. It is well known ...
Citation: Genes & Nutrition 2020 15:12
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