Articles

Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian

Cardiometabolic diseases are complex traits which are influenced by several single nucleotide polymorphisms (SNPs). Thus, analysing the combined effects of multiple gene variants might provide a better underst...

Authors: Sooad Alsulami, A. S. Aji, U. Ariyasra, S. R. Sari, N. Tasrif, F. F. Yani, J. A. Lovegrove, I. R. Sudji, N. I. Lipoeto and K. S. Vimaleswaran

Moderately high folate level may offset the effects of aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and precancerous lesions

This study evaluated gene-nutrition interactions between folate and the aberrant DNA methylation of tumor suppressor genes in different stages of carcinogenesis of esophageal squamous cell carcinoma (ESCC).

Authors: Shaokang Wang, Da Pan, Ming Su, Guiling Huang and Guiju Sun

Food intake biomarkers for berries and grapes

Grapes and berries are two types of widely consumed fruits characterized by a high content in different phytochemicals. However, their accurate dietary assessment is particularly arduous, because of the alread...

Authors: M. Ulaszewska, M. Garcia-Aloy, N. Vázquez-Manjarrez, M. T. Soria-Florido, R. Llorach, F. Mattivi and C. Manach

Predictors of stakeholders’ intention to adopt nutrigenomics

Nutrigenomics is an emerging science that studies the relationship between genes, diet and nutrients that can help prevent chronic disease. The development of this science depends on whether the public accept ...

Authors: Muhammad Adzran Che Mustapa, Latifah Amin and Lynn J. Frewer

Low-grade chronic inflammation is attenuated by exercise training in obese adults through down-regulation of ASC gene in peripheral blood: a pilot study

Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associat...

Authors: Elisa Barrón-Cabrera, Karina González-Becerra, Gustavo Rosales-Chávez, Alondra Mora-Jiménez, Iván Hernández-Cañaveral and Erika Martínez-López

Testosterone deficiency caused by castration increases adiposity in male rats in a tissue-specific and diet-dependent manner

Testosterone deficiency in men is clinically associated with the development of metabolic syndrome, which manifests as obesity, hepatic steatosis, and type-2 diabetes. We investigated the effects of castration...

Authors: Myunggi Baik, Jin Young Jeong, Seung Ju Park, Seon Pil Yoo, Jin Oh. Lee, Jae Sung Lee, Md Najmul Haque and Hyun-Jeong Lee

Melanocortin-4 receptor (MC4R) rs17782313 polymorphism interacts with Dietary Approach to Stop Hypertension (DASH) and Mediterranean Dietary Score (MDS) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals

The association with obesity of a common variant near the melanocortin-4 receptor (MC4R) gene (rs17782313) has been indicated in various studies. Adherence to dietary quality indices also have shown to have po...

Authors: Mahdieh Khodarahmi, Mohammad Asghari Jafarabadi and Mahdieh Abbasalizad Farhangi

Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice

Adiponectin and resistin are typically secreted by the adipose tissue and are abnormally expressed in obesity. However, the underlying influential factors and mechanisms are to be elucidated. It is well known ...

Authors: Hongyang Yao, Chaonan Fan, Yuanyuan Lu, Xiuqin Fan, Lulu Xia, Ping Li, Rui Wang, Tiantian Tang, Yuanyuan Wang and Kemin Qi

Biomarkers of intake for tropical fruits

Consumption of fruit and vegetable is a key component of a healthy and sustainable diet. However, their accurate dietary assessment remains a challenge. Due to errors in self-reporting methods, the available d...

Authors: N. Vázquez-Manjarrez, M. Ulaszewska, M. Garcia-Aloy, F. Mattivi, G. Praticò, L. O. Dragsted and C. Manach

Genetic risk prediction of the plasma triglyceride response to independent supplementations with eicosapentaenoic and docosahexaenoic acids: the ComparED Study

We previously built a genetic risk score (GRS) highly predictive of the plasma triglyceride (TG) response to an omega-3 fatty acid (n-3 FA) supplementation from marine sources. The objective of the present stu...

Authors: Bastien Vallée Marcotte, Janie Allaire, Frédéric Guénard, Juan de Toro-Martín, Patrick Couture, Benoît Lamarche and Marie-Claude Vohl

Effect of flaxseed oil supplementation on the erythrocyte membrane fatty acid composition and endocannabinoid system modulation in patients with coronary artery disease: a double-blind randomized controlled trial

The endocannabinoid system (ECS) overactivation, associated with increased inflammatory process, may act as a risk factor for coronary artery disease (CAD). Dietary fat may influence the ECS tone. The aim of t...

Authors: Sevda Saleh-Ghadimi, Mohammad Alizadeh, Hamed Jafari-Vayghan, Masoud Darabi, Ali Golmohammadi and Sorayya Kheirouri

Expression profiling and analysis of some miRNAs in subcutaneous white adipose tissue during development of obesity

MicroRNAs are emerging as new mediators in the regulation of adipocyte physiology and have been approved to play a role in obesity. Despite several studies have focused on microRNA expression profiles and func...

Authors: Elham M. Youssef, Asmaa M. Elfiky, BanglySoliman, Nourhan Abu-Shahba and Mahmoud M. Elhefnawi

Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review

Numerous studies acknowledged the importance of an adequate vegetable consumption for human health. However, current methods to estimate vegetable intake are often prone to measurement errors due to self-repor...

Authors: Elske M. Brouwer-Brolsma, Beate Brandl, Marion E. C. Buso, Thomas Skurk and Claudine Manach

Docosahexaenoic acid inhibits zymogen activation by suppressing vacuolar ATPase activation in cerulein-stimulated pancreatic acinar cells

The premature activation of digestive enzyme zymogens within pancreatic acinar cells is an important early feature of acute pancreatitis. Supraphysiological concentrations of cholecystokinin (CCK) cause intrap...

Authors: Yeeun Park, Leeyeon Ku, Joo Weon Lim and Hyeyoung Kim

Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations

The frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D ...

Authors: Patrice Jones, Mark Lucock, George Chaplin, Nina G. Jablonski, Martin Veysey, Christopher Scarlett and Emma Beckett

Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans

Micronutrients cannot be synthesized by humans and are obtained from three different sources: diet, gut microbiota, and oral supplements. The microbiota generates significant quantities of micronutrients, but ...

Authors: Claire Maynard and David Weinkove

Correction to: The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis

Following publication of the original article [1], the authors flagged that the ‘Availability of data and materials’ declaration is incomplete.

Authors: Francesca Vacca, Amilcare Barca, Ana S. Gomes, Aurora Mazzei, Barbara Piccinni, Raffaella Cinquetti, Gianmarco Del Vecchio, Alessandro Romano, Ivar Rønnestad, Elena Bossi and Tiziano Verri

Inflexibility of the plasma miRNA response following a high-carbohydrate meal in overweight insulin-resistant women

Metabolic inflexibility is a characteristic of insulin resistance, limiting the ability to transiently regulate oxidative metabolism and gene expression in response to nutrient availability. Little is known of...

Authors: F. Ramzan, R. F. D’Souza, B. R. Durainayagam, A. M. Milan, N. C. Roy, M. C. Kruger, C. J. Henry, C. J. Mitchell and D. Cameron-Smith

Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans

Excessive intake of carbohydrates and fats causes over-nutrition, leading to a variety of diseases and complications. Here, we characterized the effects of different types of sugar and lipids on the growth and...

Authors: Xiong Wang, Lin Zhang, Lei Zhang, Wenli Wang, Sihan Wei, Jie Wang, Huilian Che and Yali Zhang

Biomarkers of meat and seafood intake: an extensive literature review

Meat, including fish and shellfish, represents a valuable constituent of most balanced diets. Consumption of different types of meat and fish has been associated with both beneficial and adverse health effects...

Authors: Cătălina Cuparencu, Giulia Praticó, Lieselot Y. Hemeryck, Pedapati S. C. Sri Harsha, Stefania Noerman, Caroline Rombouts, Muyao Xi, Lynn Vanhaecke, Kati Hanhineva, Lorraine Brennan and Lars O. Dragsted

Current basis and future directions of zebrafish nutrigenomics

This review investigates the current state of nutrigenomics in the zebrafish animal models. The zebrafish animal model has been used extensively in the study of disease onset and progression and associated mol...

Authors: Michael B. Williams and Stephen A. Watts

The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis

Peptide transporter 1 (PepT1, alias Slc15a1) mediates the uptake of dietary di/tripeptides in all vertebrates. However, in teleost fish, more than one PepT1-type transporter might function, due to specific whole ...

Authors: Francesca Vacca, Amilcare Barca, Ana S. Gomes, Aurora Mazzei, Barbara Piccinni, Raffaella Cinquetti, Gianmarco Del Vecchio, Alessandro Romano, Ivar Rønnestad, Elena Bossi and Tiziano Verri

Increased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach

Adequate protein intake among older adults is associated with better health outcomes such as immune function and metabolic regulation of skeletal muscle, but conflicting results make it difficult to define the...

Authors: Gyrd O. Gjevestad, Kirsten B. Holven, Amanda Rundblad, Arnar Flatberg, Mari Myhrstad, Karina Karlsen, Shivaprakash J. Mutt, Karl-Heinz Herzig, Inger Ottestad and Stine M. Ulven

The role of PPARγ in childhood obesity-induced fractures

Globally, obesity is on the rise with ~ 30% of the world’s population now obese, and childhood obesity is following similar trends. Childhood obesity has been associated with numerous chronic conditions, inclu...

Authors: Matthew R. McCann and Anusha Ratneswaran

Endorsing the STrengthening the Reporting of Observational Studies in Epidemiology-nutritional epidemiology (STROBE-nut) statement at Genes & Nutrition

Authors: Dana Hawwash and Carl Lachat

Estrogen biosynthesis in cultured skeletal muscle cells (L6) induced by amino acids

Previous investigations have indicated upregulation of gene expression in cellular pathways related to the biosynthesis of steroids in response to amino acids (AA) in skeletal muscle cells. This suggests AA as...

Authors: Britt-Marie Iresjö, Andreas Landin, Claes Ohlsson and Kent Lundholm

Biomarkers of cereal food intake

Cereal foods are major contributors to the daily energy, protein, and dietary fiber intake all over the world. The role of cereals in human health is dependent on whether they are consumed as refined or whole ...

Authors: Rikard Landberg, Kati Hanhineva, Kieran Tuohy, Mar Garcia-Aloy, Izabela Biskup, Rafael Llorach, Xiaofei Yin, Lorraine Brennan and Marjukka Kolehmainen

Logical modelling reveals the PDC-PDK interaction as the regulatory switch driving metabolic flexibility at the cellular level

Metabolic flexibility is the ability of an organism to switch between substrates for energy metabolism, in response to the changing nutritional state and needs of the organism. On the cellular level, metabolic...

Authors: Samar HK Tareen, Martina Kutmon, Ilja CW Arts, Theo M de Kok, Chris T Evelo and Michiel E Adriaens

Evidence for the association between FTO gene variants and vitamin B12 concentrations in an Asian Indian population

Low vitamin B12 concentrations have been associated with major clinical outcomes, including adiposity, in Indian populations. The Fat mass and obesity-associated gene (FTO) is an established obesity-susceptibilit...

Authors: Shelini Surendran, Ramamoorthy Jayashri, Lauren Drysdale, Dhanasekaran Bodhini, Nagarajan Lakshmipriya, Coimbatore Subramanian Shanthi Rani, Vasudevan Sudha, Julie A. Lovegrove, Ranjit M. Anjana, Viswanathan Mohan, Venkatesan Radha, Rajendra Pradeepa and Karani S. Vimaleswaran

Metabolic regulation of lifespan from a C. elegans perspective

Decline of cellular functions especially cognitive is a major deficit that arises with age in humans. Harnessing the strengths of small and genetic tractable model systems has revealed key conserved regulatory...

Authors: Kathrine B. Dall and Nils J. Færgeman

Biomarkers of seaweed intake

Seaweeds are marine macroalgae, some of which are edible. They are rich in specific dietary fibers and also contain other characteristic biological constituents. Biological activities have been investigated ma...

Authors: Muyao Xi and Lars O. Dragsted

Mechanism of continuous high temperature affecting growth performance, meat quality, and muscle biochemical properties of finishing pigs

The mechanism of high ambient temperature affecting meat quality is not clear till now. This study investigated the effect of high ambient temperature on meat quality and nutrition metabolism in finishing pigs.

Authors: Xianyong Ma, Li Wang, Zibiao Shi, Wei Chen, Xuefen Yang, Youjun Hu, Chuntian Zheng and Zongyong Jiang

Dietary protein sources and tumoral overexpression of RhoA, VEGF-A and VEGFR2 genes among breast cancer patients

High protein intake may promote angiogenesis giving support to the development of metastasis according to the experimental data. However, nutritional epidemiologic evidence is inconsistent with metastasis. The...

Authors: Ali Shokri, Saeed Pirouzpanah, Mitra Foroutan-Ghaznavi, Vahid Montazeri, Ashraf Fakhrjou, Hojjatollah Nozad-Charoudeh and Gholamreza Tavoosidana

Identification of the 12q24 locus associated with fish intake frequency by genome-wide meta-analysis in Japanese populations

Japan is traditionally a country with one of the highest levels of fish consumption worldwide, although the westernization of the Japanese diet has resulted in the reduction of fish consumption. A recent meta-...

Authors: Maki Igarashi, Shun Nogawa, Kaoru Kawafune, Tsuyoshi Hachiya, Shoko Takahashi, Huijuan Jia, Kenji Saito and Hisanori Kato

Effect of gestational oily fish intake on the risk of allergy in children may be influenced by FADS1/2, ELOVL5 expression and DNA methylation

Evidence suggests that prenatal exposure to n-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease in children. LCPUFAs are produced from dietary precursors catalyzed by des...

Authors: Purevsuren Losol, Faisal I. Rezwan, Veeresh K. Patil, Carina Venter, Susan Ewart, Hongmei Zhang, S. Hasan Arshad, Wilfried Karmaus and John W. Holloway

Interaction between the amount of dietary protein and the environmental temperature on the expression of browning markers in adipose tissue of rats

A low-protein diet increases the expression and circulating concentration of FGF21. FGF21 stimulates the browning process of WAT by enhancing the expression of UCP1 coupled with an increase in PGC1α. Interesti...

Authors: Gabriela Alemán, Ana Laura Castro, Ana Vigil-Martínez, Ivan Torre-Villalvazo, Andrea Díaz-Villaseñor, Lilia G. Noriega, Isabel Medina-Vera, Guillermo Ordáz, Nimbe Torres and Armando R. Tovar

Herbs and Spices- Biomarkers of Intake Based on Human Intervention Studies – A Systematic Review

Culinary herbs and spices have been used as both food flavoring and food preservative agents for centuries. Moreover, due to their known and presumptive health benefits, herbs and spices have also been used in...

Authors: Rosa Vázquez-Fresno, Albert Remus R. Rosana, Tanvir Sajed, Tuviere Onookome-Okome, Noah A. Wishart and David S. Wishart

Maternal dietary glycaemic change during gestation influences insulin-related gene methylation in the placental tissue: a genome-wide methylation analysis

Studies have shown that the effects of maternal nutrition exposure during gestation influence metabolic risk in early life through an epigenetic mechanism. Low glycaemic index (GI) diets benefit both maternal ...

Authors: Weili Yan, Yi Zhang, Liping Wang, Wenhong Yang, Chunying Li, Liling Wang, Ping Gu, Yingqian Xia, Juhua Yan, Ying Shen, Qian Zhao, Dayan Niu, Kai Mu and Yuan Jiang

Weighted gene co-expression network analysis to explain the relationship between plasma total carotenoids and lipid profile

Variability in circulating carotenoids may be attributable to several factors including, among others, genetic variants and lipid profile. However, relatively few studies have considered the impact of gene exp...

Authors: Bénédicte L. Tremblay, Frédéric Guénard, Benoît Lamarche, Louis Pérusse and Marie-Claude Vohl

The nutritional requirements of Caenorhabditis elegans

Animals require sufficient intake of a variety of nutrients to support their development, somatic maintenance and reproduction. An adequate diet provides cell building blocks, chemical energy to drive cellular...

Authors: Aleksandra Zečić, Ineke Dhondt and Bart P. Braeckman

Drosophila melanogaster as an alternative model organism in nutrigenomics

Nutrigenomics explains the interaction between the genome, the proteome, the epigenome, the metabolome, and the microbiome with the nutritional environment of an organism. It is therefore situated at the inter...

Authors: Nieves Baenas and Anika E. Wagner

TAS2R38 bitter taste genotype is associated with complementary feeding behavior in infants

Genetically mediated sensitivity to bitter taste has been associated with food preferences and eating behavior in adults and children. The aim of this study was to assess the association between TAS2R38 bitter...

Authors: Gabriele Cont, Giulia Paviotti, Marcella Montico, Paola Paganin, Martina Guerra, Antonella Trappan, Sergio Demarini, Paolo Gasparini and Antonietta Robino

Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach

Aging is a complex phenomenon caused by the time-dependent loss of cellular homeodynamics and consequently of physiological organismal functions. This process is affected by both genetic and environmental (e.g...

Authors: Zoi Evangelakou, Maria Manola, Sentiljana Gumeni and Ioannis P. Trougakos

Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes

Olfaction is an important sense influencing food preferences, appetite, and eating behaviors. This hypothesis-driven study aimed to assess associations between olfactory pathway gene methylation signatures, ob...

Authors: Omar Ramos-Lopez, Jose I. Riezu-Boj, Fermin I. Milagro, M. Angeles Zulet, Jose L. Santos and J. Alfredo Martinez

Differences in peripheral blood mononuclear cell gene expression and triglyceride composition in lipoprotein subclasses in plasma triglyceride responders and non-responders to omega-3 supplementation

Intake of the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduces fasting triglyceride (TG) levels and may thereby lower cardiovascular disease risk. However, there ar...

Authors: Amanda Rundblad, Sunniva V. Larsen, Mari C. Myhrstad, Inger Ottestad, Magne Thoresen, Kirsten B. Holven and Stine M. Ulven

Biomarkers of tuber intake

Tubers are important crops as well as staple foods in human nutrition. Among tubers, the potato in particular has been investigated for its health effects. However, except for its contribution to energy and ef...

Authors: Xiaomin Zhou, Qian Gao, Giulia Praticò, Jie Chen and Lars Ove Dragsted

Transcriptional response of cultured porcine intestinal epithelial cells to micro algae extracts in the presence and absence of enterotoxigenic Escherichia coli

Micro algae’s are worldwide considered as an alternative source of proteins in diets for animals and humans. Micro algae also produce an array of biological active substances with potential to induce beneficia...

Authors: Marcel Hulst, Rommie van der Weide, Arjan Hoekman and Marinus van Krimpen

Biomarkers of food intake for nuts and vegetable oils: an extensive literature search

Nuts and vegetable oils are important sources of fat and of a wide variety of micronutrients and phytochemicals. Following their intake, several of their constituents, as well as their derived metabolites, are...

Authors: Mar Garcia-Aloy, Paul J. M. Hulshof, Sheila Estruel-Amades, Maryse C. J. Osté, Maria Lankinen, Johanna M. Geleijnse, Janette de Goede, Marynka Ulaszewska, Fulvio Mattivi, Stephan J. L. Bakker, Ursula Schwab and Cristina Andres-Lacueva

High-throughput sequencing of small RNAs and analysis of differentially expressed microRNAs associated with high-fat diet-induced hepatic insulin resistance in mice

Hepatic insulin resistance (IR) plays a crucial role in the development of many metabolic diseases, such as type 2 diabetes. MicroRNAs (miRNAs) are involved in the pathogenesis of IR and related diseases; howe...

Authors: Xue Zhao, Zhao Chen, Zengyuan Zhou, Yuzheng Li, Yuanyuan Wang, Zihao Zhou, Huimin Lu, Changhao Sun and Xia Chu

Current knowledge and interest of French Canadians regarding nutrigenetics

The purpose of this study was to draw a global portrait of the current knowledge and interest regarding nutrigenetics in a population of French Canadians from the province of Quebec (Canada).

Authors: Bastien Vallée Marcotte, Hubert Cormier, Véronique Garneau, Julie Robitaille, Sophie Desroches and Marie-Claude Vohl