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  1. Research

    Bioavailability of transgenic microRNAs in genetically modified plants

    Transgenic expression of small RNAs is a prevalent approach in agrobiotechnology for the global enhancement of plant foods. Meanwhile, emerging studies have, on the one hand, emphasized the potential of transg...

    Jian Yang, Cecilia Primo, Ismail Elbaz-Younes and Kendal D. Hirschi

    Genes & Nutrition 2017 12:17

    Published on: 7 July 2017

  2. Research

    Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study

    A polymorphism in a gene may exert its effects on multiple phenotypes. The aim of this study is to explore the association of 10 metabolic syndrome candidate genes with excess weight and adiposity and evaluate...

    Angélica María Muñoz, Claudia María Velásquez, Gloria María Agudelo, Rosa Magdalena Uscátegui, Alejandro Estrada, Fredy Alonso Patiño, Beatriz Elena Parra, María Victoria Parra and Gabriel Bedoya

    Genes & Nutrition 2017 12:19

    Published on: 4 July 2017

  3. Discussion

    Diet-derived microRNAs: unicorn or silver bullet?

    In ancient lore, a bullet cast from silver is the only effective weapon against monsters. The uptake of active diet-derived microRNAs (miRNAs) in consumers may be the silver bullet long sought after in nutriti...

    Kenneth W. Witwer and Chen-Yu Zhang

    Genes & Nutrition 2017 12:15

    Published on: 22 June 2017

  4. Editorial

    Navigating dietary small RNAs

    When a novel nutritional concept comes along, scientists become enthusiastic and start new explorations. In 2012, the field was enthralled with a study suggesting plant-based nucleic acid “information” acts as...

    Kendal D. Hirschi

    Genes & Nutrition 2017 12:16

    Published on: 22 June 2017

  5. Commentary

    Milk exosomes: beyond dietary microRNAs

    Extracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line ...

    Janos Zempleni

    Genes & Nutrition 2017 12:12

    Published on: 22 June 2017

  6. Review

    Obesity and microbiota: an example of an intricate relationship

    It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression ...

    Sabrina Duranti, Chiara Ferrario, Douwe van Sinderen, Marco Ventura and Francesca Turroni

    Genes & Nutrition 2017 12:18

    Published on: 15 June 2017

  7. Research

    Enrichment of in vivo transcription data from dietary intervention studies with in vitro data provides improved insight into gene regulation mechanisms in the intestinal mucosa

    Gene expression profiles of intestinal mucosa of chickens and pigs fed over long-term periods (days/weeks) with a diet rich in rye and a diet supplemented with zinc, respectively, or of chickens after a one-da...

    Marcel Hulst, Alfons Jansman, Ilonka Wijers, Arjan Hoekman, Stéphanie Vastenhouw, Marinus van Krimpen, Mari Smits and Dirkjan Schokker

    Genes & Nutrition 2017 12:11

    Published on: 13 April 2017

  8. Research

    Transcriptomic responses of the liver and adipose tissues to altered carbohydrate-fat ratio in diet: an isoenergetic study in young rats

    To elucidate the effects of altered dietary carbohydrate and fat balance on liver and adipose tissue transcriptomes, 3-week-old rats were fed three kinds of diets: low-, moderate-, and high-fat diets (L, M, an...

    Mitsuru Tanaka, Akihito Yasuoka, Manae Shimizu, Yoshikazu Saito, Kei Kumakura, Tomiko Asakura and Toshitada Nagai

    Genes & Nutrition 2017 12:10

    Published on: 8 April 2017

  9. Research

    Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise

    High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expressi...

    Gyrd O. Gjevestad, Håvard Hamarsland, Truls Raastad, Inger Ottestad, Jacob J. Christensen, Kristin Eckardt, Christian A. Drevon, Anne S. Biong, Stine M. Ulven and Kirsten B. Holven

    Genes & Nutrition 2017 12:8

    Published on: 3 March 2017

  10. Review

    Food components and contaminants as (anti)androgenic molecules

    Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood...

    Daniele Marcoccia, Marco Pellegrini, Marco Fiocchetti, Stefano Lorenzetti and Maria Marino

    Genes & Nutrition 2017 12:6

    Published on: 16 February 2017

  11. Research

    The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility

    Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respo...

    Tim J. van den Broek, Bas H. A. Kremer, Marisa Marcondes Rezende, Femke P. M. Hoevenaars, Peter Weber, Ulrich Hoeller, Ben van Ommen and Suzan Wopereis

    Genes & Nutrition 2017 12:5

    Published on: 8 February 2017

  12. Research

    A porcine gluteus medius muscle genome-wide transcriptome analysis: dietary effects of omega-6 and omega-3 fatty acids on biological mechanisms

    The level of omega-6 and omega-3 polyunsaturated fatty acids can affect many cellular systems and function via nuclear receptors or the bioactive lipid regulation of gene expression. The objective of this stud...

    Magdalena Ogłuszka, Agnieszka Szostak, Marinus F. W. te Pas, Ewa Poławska, Paweł Urbański, Tadeusz Blicharski, Chandra S. Pareek, Edyta Juszczuk-Kubiak, Jenelle R. Dunkelberger, Jarosław O. Horbańczuk and Mariusz Pierzchała

    Genes & Nutrition 2017 12:4

    Published on: 31 January 2017

  13. Editorial

    Propelling the paradigm shift from reductionism to systems nutrition

    The complex physiology of living organisms represents a challenge for mechanistic understanding of the action of dietary bioactives in the human body and of their possible role in health and disease. Animal, c...

    Jim Kaput, Giuditta Perozzi, Marijana Radonjic and Fabio Virgili

    Genes & Nutrition 2017 12:3

    Published on: 25 January 2017

  14. Research

    Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat’s liver

    Hepatic fatty acids (FAs) are modified through different metabolic pathways including elongation and desaturation. These processes are catalyzed by elongases and desaturases, respectively. Glucose, by transcri...

    Jagoda Drąg, Anna Goździalska, Małgorzata Knapik-Czajka, Anna Gawędzka, Katarzyna Gawlik and Jerzy Jaśkiewicz

    Genes & Nutrition 2017 12:2

    Published on: 25 January 2017

  15. Research

    Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny

    Epidemiological studies suggest that hyponutrition during the fetal period increases the risk of mental disorders such as attention deficit hyperactivity disorder and autism-spectrum disorder, which has been e...

    Tamio Furuse, Kunio Miyake, Takashi Kohda, Hideki Kaneda, Takae Hirasawa, Ikuko Yamada, Tomoko Kushida, Misho Kashimura, Kimio Kobayashi, Fumitoshi Ishino, Takeo Kubota and Shigeharu Wakana

    Genes & Nutrition 2017 12:1

    Published on: 19 January 2017

  16. Research

    Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells

    We have previously reported that γ- and δ-tocotrienols (γ- and δ-T3) induce gene expression and apoptosis in human breast cancer cells (MDA-MB-231 and MCF-7). This effect is mediated, at least in part, by a sp...

    Raffaella Comitato, Barbara Guantario, Guido Leoni, Kalanithi Nesaretnam, Maria Beatrice Ronci, Raffaella Canali and Fabio Virgili

    Genes & Nutrition 2016 11:32

    Published on: 23 December 2016

  17. Research

    Time-course microarray analysis for identifying candidate genes involved in obesity-associated pathological changes in the mouse colon

    Obesity is known to increase the risk of colorectal cancer. However, mechanisms underlying the pathogenesis of obesity-induced colorectal cancer are not completely understood. The purposes of this study were t...

    Yun Jung Bae, Sung-Eun Kim, Seong Yeon Hong, Taesun Park, Sang Gyu Lee, Myung-Sook Choi and Mi-Kyung Sung

    Genes & Nutrition 2016 11:30

    Published on: 22 November 2016

  18. Research

    Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats

    The Nile rat (NR, Arvicanthis niloticus) is a model of carbohydrate-induced type 2 diabetes mellitus (T2DM) and the metabolic syndrome. A previous study found that palm fruit juice (PFJ) delayed or prevented diab...

    Soon-Sen Leow, Julia Bolsinger, Andrzej Pronczuk, K. C. Hayes and Ravigadevi Sambanthamurthi

    Genes & Nutrition 2016 11:29

    Published on: 22 October 2016

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