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  1. Research

    Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition

    Obesity is a complex pathology associated with dysbiosis, metabolic alterations, and low-grade chronic inflammation promoted by immune cells, infiltrating and populating the adipose tissue. Probiotic supplemen...

    Marianna Roselli, Chiara Devirgiliis, Paola Zinno, Barbara Guantario, Alberto Finamore, Rita Rami and Giuditta Perozzi

    Genes & Nutrition 2017 12:25

    Published on: 4 October 2017

  2. Review

    Does dietary fat affect inflammatory markers in overweight and obese individuals?—a review of randomized controlled trials from 2010 to 2016

    Obesity, a major cause of death and disability, is increasing worldwide. Obesity is characterized by a chronic, low-grade inflammatory state which is suggested to play a critical role in the development of obe...

    Vibeke H. Telle-Hansen, Jacob J. Christensen, Stine M. Ulven and Kirsten B. Holven

    Genes & Nutrition 2017 12:26

    Published on: 4 October 2017

  3. Review

    Amino acid supplements and metabolic health: a potential interplay between intestinal microbiota and systems control

    Dietary supplementation of essential amino acids (EAAs) has been shown to promote healthspan. EAAs regulate, in fact, glucose and lipid metabolism and energy balance, increase mitochondrial biogenesis, and mai...

    Francesco Bifari, Chiara Ruocco, Ilaria Decimo, Guido Fumagalli, Alessandra Valerio and Enzo Nisoli

    Genes & Nutrition 2017 12:27

    Published on: 4 October 2017

  4. Research

    Ancestors’ dietary patterns and environments could drive positive selection in genes involved in micronutrient metabolism—the case of cofactor transporters

    During evolution, humans colonized different ecological niches and adopted a variety of subsistence strategies that gave rise to diverse selective pressures acting across the genome. Environmentally induced se...

    Silvia Parolo, Sébastien Lacroix, Jim Kaput and Marie-Pier Scott-Boyer

    Genes & Nutrition 2017 12:28

    Published on: 4 October 2017

  5. Commentary

    Dietary and health biomarkers—time for an update

    In the dietary and health research area, biomarkers are extensively used for multiple purposes. These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects...

    Lars O. Dragsted, Qian Gao, Giulia Praticò, Claudine Manach, David S. Wishart, Augustin Scalbert and Edith J. M. Feskens

    Genes & Nutrition 2017 12:24

    Published on: 29 September 2017

  6. Review

    Role of microRNAs in obesity and obesity-related diseases

    In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in mai...

    Giuseppe Iacomino and Alfonso Siani

    Genes & Nutrition 2017 12:23

    Published on: 25 September 2017

  7. Research

    Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology

    Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administer...

    Isabelle R. Miousse, Rupak Pathak, Sarita Garg, Charles M. Skinner, Stepan Melnyk, Oleksandra Pavliv, Howard Hendrickson, Reid D. Landes, Annie Lumen, Alan J. Tackett, Nicolaas E.P. Deutz, Martin Hauer-Jensen and Igor Koturbash

    Genes & Nutrition 2017 12:22

    Published on: 6 September 2017

  8. Research

    Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

    A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultane...

    Suzan Wopereis, Johanna H. M. Stroeve, Annette Stafleu, Gertruud C. M. Bakker, Jacobus Burggraaf, Marjan J. van Erk, Linette Pellis, Ruud Boessen, Alwine A. F. Kardinaal and Ben van Ommen

    Genes & Nutrition 2017 12:21

    Published on: 29 August 2017

  9. Research

    Lactase persistence in Tunisia as a result of admixture with other Mediterranean populations

    The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of...

    Yosra Ben Halima, Rym Kefi, Marco Sazzini, Cristina Giuliani, Sara De Fanti, Chokri Nouali, Majdi Nagara, Giacomo Mengozzi, Sahar Elouej, Abdelmajid Abid, Henda Jamoussi, Lotfi Chouchane, Giovanni Romeo, Sonia Abdelhak and Donata Luiselli

    Genes & Nutrition 2017 12:20

    Published on: 24 August 2017

  10. Research

    Bioavailability of transgenic microRNAs in genetically modified plants

    Transgenic expression of small RNAs is a prevalent approach in agrobiotechnology for the global enhancement of plant foods. Meanwhile, emerging studies have, on the one hand, emphasized the potential of transg...

    Jian Yang, Cecilia Primo, Ismail Elbaz-Younes and Kendal D. Hirschi

    Genes & Nutrition 2017 12:17

    Published on: 7 July 2017

  11. Research

    Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study

    A polymorphism in a gene may exert its effects on multiple phenotypes. The aim of this study is to explore the association of 10 metabolic syndrome candidate genes with excess weight and adiposity and evaluate...

    Angélica María Muñoz, Claudia María Velásquez, Gloria María Agudelo, Rosa Magdalena Uscátegui, Alejandro Estrada, Fredy Alonso Patiño, Beatriz Elena Parra, María Victoria Parra and Gabriel Bedoya

    Genes & Nutrition 2017 12:19

    Published on: 4 July 2017

  12. Discussion

    Diet-derived microRNAs: unicorn or silver bullet?

    In ancient lore, a bullet cast from silver is the only effective weapon against monsters. The uptake of active diet-derived microRNAs (miRNAs) in consumers may be the silver bullet long sought after in nutriti...

    Kenneth W. Witwer and Chen-Yu Zhang

    Genes & Nutrition 2017 12:15

    Published on: 22 June 2017

  13. Editorial

    Navigating dietary small RNAs

    When a novel nutritional concept comes along, scientists become enthusiastic and start new explorations. In 2012, the field was enthralled with a study suggesting plant-based nucleic acid “information” acts as...

    Kendal D. Hirschi

    Genes & Nutrition 2017 12:16

    Published on: 22 June 2017

  14. Commentary

    Milk exosomes: beyond dietary microRNAs

    Extracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line ...

    Janos Zempleni

    Genes & Nutrition 2017 12:12

    Published on: 22 June 2017

  15. Review

    Obesity and microbiota: an example of an intricate relationship

    It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression ...

    Sabrina Duranti, Chiara Ferrario, Douwe van Sinderen, Marco Ventura and Francesca Turroni

    Genes & Nutrition 2017 12:18

    Published on: 15 June 2017

  16. Research

    Enrichment of in vivo transcription data from dietary intervention studies with in vitro data provides improved insight into gene regulation mechanisms in the intestinal mucosa

    Gene expression profiles of intestinal mucosa of chickens and pigs fed over long-term periods (days/weeks) with a diet rich in rye and a diet supplemented with zinc, respectively, or of chickens after a one-da...

    Marcel Hulst, Alfons Jansman, Ilonka Wijers, Arjan Hoekman, Stéphanie Vastenhouw, Marinus van Krimpen, Mari Smits and Dirkjan Schokker

    Genes & Nutrition 2017 12:11

    Published on: 13 April 2017

  17. Research

    Transcriptomic responses of the liver and adipose tissues to altered carbohydrate-fat ratio in diet: an isoenergetic study in young rats

    To elucidate the effects of altered dietary carbohydrate and fat balance on liver and adipose tissue transcriptomes, 3-week-old rats were fed three kinds of diets: low-, moderate-, and high-fat diets (L, M, an...

    Mitsuru Tanaka, Akihito Yasuoka, Manae Shimizu, Yoshikazu Saito, Kei Kumakura, Tomiko Asakura and Toshitada Nagai

    Genes & Nutrition 2017 12:10

    Published on: 8 April 2017

  18. Research

    Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise

    High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expressi...

    Gyrd O. Gjevestad, Håvard Hamarsland, Truls Raastad, Inger Ottestad, Jacob J. Christensen, Kristin Eckardt, Christian A. Drevon, Anne S. Biong, Stine M. Ulven and Kirsten B. Holven

    Genes & Nutrition 2017 12:8

    Published on: 3 March 2017

  19. Review

    Food components and contaminants as (anti)androgenic molecules

    Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood...

    Daniele Marcoccia, Marco Pellegrini, Marco Fiocchetti, Stefano Lorenzetti and Maria Marino

    Genes & Nutrition 2017 12:6

    Published on: 16 February 2017

  20. Research

    The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility

    Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respo...

    Tim J. van den Broek, Bas H. A. Kremer, Marisa Marcondes Rezende, Femke P. M. Hoevenaars, Peter Weber, Ulrich Hoeller, Ben van Ommen and Suzan Wopereis

    Genes & Nutrition 2017 12:5

    Published on: 8 February 2017

  21. Research

    A porcine gluteus medius muscle genome-wide transcriptome analysis: dietary effects of omega-6 and omega-3 fatty acids on biological mechanisms

    The level of omega-6 and omega-3 polyunsaturated fatty acids can affect many cellular systems and function via nuclear receptors or the bioactive lipid regulation of gene expression. The objective of this stud...

    Magdalena Ogłuszka, Agnieszka Szostak, Marinus F. W. te Pas, Ewa Poławska, Paweł Urbański, Tadeusz Blicharski, Chandra S. Pareek, Edyta Juszczuk-Kubiak, Jenelle R. Dunkelberger, Jarosław O. Horbańczuk and Mariusz Pierzchała

    Genes & Nutrition 2017 12:4

    Published on: 31 January 2017

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