Articles

Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesis

Peripheral blood mononuclear cells (PBMCs) have shown promise as a tissue sensitive to subtle and possibly systemic transcriptomic changes, and as such may be useful in identifying responses to weight loss int...

Authors: Kaitlin Day, Aimee L. Dordevic, Helen Truby, Melissa C. Southey, Susan Coort and Chiara Murgia

Correction to: TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis

Authors: Rui Guo, Yunjin Zhang, Yue Yu, Shenghan Su, Qingrui Zhao, Xia Chu, Shenglong Li, Huimin Lu and Changhao Sun

The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study

In recent years, the exciting emergence of circulating miRNAs as stable, reproducible, and consistent among individuals has opened a promising research opportunity for the detection of non-invasive biomarkers....

Authors: Giuseppe Iacomino, Fabio Lauria, Paola Russo, Antonella Venezia, Nunzia Iannaccone, Pasquale Marena, Wolfgang Ahrens, Stefaan De Henauw, Dénes Molnár, Gabriele Eiben, Ronja Foraita, Antje Hebestreit, Giannis Kourides, Luis A. Moreno, Toomas Veidebaum and Alfonso Siani

Serum iron status and the risk of breast cancer in the European population: a two-sample Mendelian randomisation study

Previous observational studies have provided conflicting results on the association between serum iron status and the risk of breast cancer. Considering the relevance of this relationship to breast cancer prev...

Authors: Chenyang Hou, Qingzhi Hou, Xing Xie, Huifeng Wang, Yueliang Chen, Tingxi Lu, Qunying Wu, Yongcong Liang, Yanling Hu and Yuang Mao

TCONS_00230836 silencing restores stearic acid-induced β cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis

Chronic exposure of pancreatic β cells to high levels of stearic acid (C18:0) leads to impaired insulin secretion, which accelerates the progression of type 2 diabetes mellitus (T2DM). Recently, long noncoding...

Authors: Rui Guo, Yunjin Zhang, Yue Yu, Shenghan Su, Qingrui Zhao, Xia Chu, Shenglong Li, Huimin Lu✉ and Changhao Sun

An 8-week freeze-dried blueberry supplement impacts immune-related pathways: a randomized, double-blind placebo-controlled trial

Blueberries contain high levels of polyphenolic compounds with high in vitro antioxidant capacities. Their consumption has been associated with improved vascular and metabolic health.

Authors: Michèle Rousseau, Justine Horne, Frédéric Guénard, Juan de Toro-Martín, Véronique Garneau, Valérie Guay, Michèle Kearney, Geneviève Pilon, Denis Roy, Patrick Couture, Charles Couillard, André Marette and Marie-Claude Vohl

Association of vitamin D pathway genes polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population

This study aimed to evaluate the association of single nucleotide polymorphisms (SNPs) of vitamin D metabolic pathway genes with susceptibility to pulmonary tuberculosis (PTB).

Authors: Tian-Ping Zhang, Shuang-Shuang Chen, Gen-You Zhang, Si-Jiu Shi, Li Wei and Hong-Miao Li

A systematic review to identify biomarkers of intake for fermented food products

Fermented foods are ubiquitous in human diets and often lauded for their sensory, nutritious, and health-promoting qualities. However, precise associations between the intake of fermented foods and health have...

Authors: Katherine J. Li, Elske M. Brouwer-Brolsma, Kathryn J. Burton-Pimentel, Guy Vergères and Edith J. M. Feskens

Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese

Previous studies have found the important gene-diet interactions on type 2 diabetes (T2D) incident but have not followed branched-chain amino acids (BCAAs), even though they have shown heterogeneous effectiven...

Authors: Weiqi Wang, Haiyang Jiang, Ziwei Zhang, Wei Duan, Tianshu Han and Changhao Sun

Consumer acceptance of genetic-based personalized nutrition in Hungary

Despite the increasing number of personalized nutrition services available on the market, nutrigenomics-based level of personalization is still the exception rather than a mainstream activity. This can be part...

Authors: Zoltán Szakály, Bence Kovács, Márk Szakály, Dorka T. Nagy-Pető, Péter Popovics and Marietta Kiss

Will guidelines on alcohol consumption be personalized by a genetic approach?

Authors: Simona Costanzo, Fabio Virgili and Salvatore Panico

Maternal folic acid impacts DNA methylation profile in male rat offspring implicated in neurodevelopment and learning/memory abilities

Periconceptional folic acid (FA) supplementation not only reduces the incidence of neural tube defects, but also improves cognitive performances in offspring. However, the genes or pathways that are epigenetic...

Authors: Xinyan Wang, Zhenshu Li, Yun Zhu, Jing Yan, Huan Liu, Guowei Huang and Wen Li

DNA methylation during human adipogenesis and the impact of fructose

Increased adipogenesis and altered adipocyte function contribute to the development of obesity and associated comorbidities. Fructose modified adipocyte metabolism compared to glucose, but the regulatory mecha...

Authors: Giulia Tini, Vijayalakshmi Varma, Rosario Lombardo, Greg T. Nolen, Gregory Lefebvre, Patrick Descombes, Sylviane Métairon, Corrado Priami, Jim Kaput and Marie-Pier Scott-Boyer

Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies

This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women.

Authors: Jun Long Liao, Qiang Qin, Yong Sheng Zhou, Ru Ping Ma, He Chao Zhou, Mao Rong Gu, Yun Ping Feng, Bo Yuan Wang and Ling Yang

Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian

Cardiometabolic diseases are complex traits which are influenced by several single nucleotide polymorphisms (SNPs). Thus, analysing the combined effects of multiple gene variants might provide a better underst...

Authors: Sooad Alsulami, A. S. Aji, U. Ariyasra, S. R. Sari, N. Tasrif, F. F. Yani, J. A. Lovegrove, I. R. Sudji, N. I. Lipoeto and K. S. Vimaleswaran

Moderately high folate level may offset the effects of aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and precancerous lesions

This study evaluated gene-nutrition interactions between folate and the aberrant DNA methylation of tumor suppressor genes in different stages of carcinogenesis of esophageal squamous cell carcinoma (ESCC).

Authors: Shaokang Wang, Da Pan, Ming Su, Guiling Huang and Guiju Sun

Food intake biomarkers for berries and grapes

Grapes and berries are two types of widely consumed fruits characterized by a high content in different phytochemicals. However, their accurate dietary assessment is particularly arduous, because of the alread...

Authors: M. Ulaszewska, M. Garcia-Aloy, N. Vázquez-Manjarrez, M. T. Soria-Florido, R. Llorach, F. Mattivi and C. Manach

Predictors of stakeholders’ intention to adopt nutrigenomics

Nutrigenomics is an emerging science that studies the relationship between genes, diet and nutrients that can help prevent chronic disease. The development of this science depends on whether the public accept ...

Authors: Muhammad Adzran Che Mustapa, Latifah Amin and Lynn J. Frewer

Low-grade chronic inflammation is attenuated by exercise training in obese adults through down-regulation of ASC gene in peripheral blood: a pilot study

Obesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associat...

Authors: Elisa Barrón-Cabrera, Karina González-Becerra, Gustavo Rosales-Chávez, Alondra Mora-Jiménez, Iván Hernández-Cañaveral and Erika Martínez-López

Testosterone deficiency caused by castration increases adiposity in male rats in a tissue-specific and diet-dependent manner

Testosterone deficiency in men is clinically associated with the development of metabolic syndrome, which manifests as obesity, hepatic steatosis, and type-2 diabetes. We investigated the effects of castration...

Authors: Myunggi Baik, Jin Young Jeong, Seung Ju Park, Seon Pil Yoo, Jin Oh. Lee, Jae Sung Lee, Md Najmul Haque and Hyun-Jeong Lee

Melanocortin-4 receptor (MC4R) rs17782313 polymorphism interacts with Dietary Approach to Stop Hypertension (DASH) and Mediterranean Dietary Score (MDS) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals

The association with obesity of a common variant near the melanocortin-4 receptor (MC4R) gene (rs17782313) has been indicated in various studies. Adherence to dietary quality indices also have shown to have po...

Authors: Mahdieh Khodarahmi, Mohammad Asghari Jafarabadi and Mahdieh Abbasalizad Farhangi

Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice

Adiponectin and resistin are typically secreted by the adipose tissue and are abnormally expressed in obesity. However, the underlying influential factors and mechanisms are to be elucidated. It is well known ...

Authors: Hongyang Yao, Chaonan Fan, Yuanyuan Lu, Xiuqin Fan, Lulu Xia, Ping Li, Rui Wang, Tiantian Tang, Yuanyuan Wang and Kemin Qi

Biomarkers of intake for tropical fruits

Consumption of fruit and vegetable is a key component of a healthy and sustainable diet. However, their accurate dietary assessment remains a challenge. Due to errors in self-reporting methods, the available d...

Authors: N. Vázquez-Manjarrez, M. Ulaszewska, M. Garcia-Aloy, F. Mattivi, G. Praticò, L. O. Dragsted and C. Manach

Genetic risk prediction of the plasma triglyceride response to independent supplementations with eicosapentaenoic and docosahexaenoic acids: the ComparED Study

We previously built a genetic risk score (GRS) highly predictive of the plasma triglyceride (TG) response to an omega-3 fatty acid (n-3 FA) supplementation from marine sources. The objective of the present stu...

Authors: Bastien Vallée Marcotte, Janie Allaire, Frédéric Guénard, Juan de Toro-Martín, Patrick Couture, Benoît Lamarche and Marie-Claude Vohl

Effect of flaxseed oil supplementation on the erythrocyte membrane fatty acid composition and endocannabinoid system modulation in patients with coronary artery disease: a double-blind randomized controlled trial

The endocannabinoid system (ECS) overactivation, associated with increased inflammatory process, may act as a risk factor for coronary artery disease (CAD). Dietary fat may influence the ECS tone. The aim of t...

Authors: Sevda Saleh-Ghadimi, Mohammad Alizadeh, Hamed Jafari-Vayghan, Masoud Darabi, Ali Golmohammadi and Sorayya Kheirouri

Expression profiling and analysis of some miRNAs in subcutaneous white adipose tissue during development of obesity

MicroRNAs are emerging as new mediators in the regulation of adipocyte physiology and have been approved to play a role in obesity. Despite several studies have focused on microRNA expression profiles and func...

Authors: Elham M. Youssef, Asmaa M. Elfiky, BanglySoliman, Nourhan Abu-Shahba and Mahmoud M. Elhefnawi

Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review

Numerous studies acknowledged the importance of an adequate vegetable consumption for human health. However, current methods to estimate vegetable intake are often prone to measurement errors due to self-repor...

Authors: Elske M. Brouwer-Brolsma, Beate Brandl, Marion E. C. Buso, Thomas Skurk and Claudine Manach

Docosahexaenoic acid inhibits zymogen activation by suppressing vacuolar ATPase activation in cerulein-stimulated pancreatic acinar cells

The premature activation of digestive enzyme zymogens within pancreatic acinar cells is an important early feature of acute pancreatitis. Supraphysiological concentrations of cholecystokinin (CCK) cause intrap...

Authors: Yeeun Park, Leeyeon Ku, Joo Weon Lim and Hyeyoung Kim

Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations

The frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D ...

Authors: Patrice Jones, Mark Lucock, George Chaplin, Nina G. Jablonski, Martin Veysey, Christopher Scarlett and Emma Beckett

Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans

Micronutrients cannot be synthesized by humans and are obtained from three different sources: diet, gut microbiota, and oral supplements. The microbiota generates significant quantities of micronutrients, but ...

Authors: Claire Maynard and David Weinkove

Correction to: The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis

Following publication of the original article [1], the authors flagged that the ‘Availability of data and materials’ declaration is incomplete.

Authors: Francesca Vacca, Amilcare Barca, Ana S. Gomes, Aurora Mazzei, Barbara Piccinni, Raffaella Cinquetti, Gianmarco Del Vecchio, Alessandro Romano, Ivar Rønnestad, Elena Bossi and Tiziano Verri

Inflexibility of the plasma miRNA response following a high-carbohydrate meal in overweight insulin-resistant women

Metabolic inflexibility is a characteristic of insulin resistance, limiting the ability to transiently regulate oxidative metabolism and gene expression in response to nutrient availability. Little is known of...

Authors: F. Ramzan, R. F. D’Souza, B. R. Durainayagam, A. M. Milan, N. C. Roy, M. C. Kruger, C. J. Henry, C. J. Mitchell and D. Cameron-Smith

Effects of excess sugars and lipids on the growth and development of Caenorhabditis elegans

Excessive intake of carbohydrates and fats causes over-nutrition, leading to a variety of diseases and complications. Here, we characterized the effects of different types of sugar and lipids on the growth and...

Authors: Xiong Wang, Lin Zhang, Lei Zhang, Wenli Wang, Sihan Wei, Jie Wang, Huilian Che and Yali Zhang

Biomarkers of meat and seafood intake: an extensive literature review

Meat, including fish and shellfish, represents a valuable constituent of most balanced diets. Consumption of different types of meat and fish has been associated with both beneficial and adverse health effects...

Authors: Cătălina Cuparencu, Giulia Praticó, Lieselot Y. Hemeryck, Pedapati S. C. Sri Harsha, Stefania Noerman, Caroline Rombouts, Muyao Xi, Lynn Vanhaecke, Kati Hanhineva, Lorraine Brennan and Lars O. Dragsted

Current basis and future directions of zebrafish nutrigenomics

This review investigates the current state of nutrigenomics in the zebrafish animal models. The zebrafish animal model has been used extensively in the study of disease onset and progression and associated mol...

Authors: Michael B. Williams and Stephen A. Watts

The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis

Peptide transporter 1 (PepT1, alias Slc15a1) mediates the uptake of dietary di/tripeptides in all vertebrates. However, in teleost fish, more than one PepT1-type transporter might function, due to specific whole ...

Authors: Francesca Vacca, Amilcare Barca, Ana S. Gomes, Aurora Mazzei, Barbara Piccinni, Raffaella Cinquetti, Gianmarco Del Vecchio, Alessandro Romano, Ivar Rønnestad, Elena Bossi and Tiziano Verri

Increased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach

Adequate protein intake among older adults is associated with better health outcomes such as immune function and metabolic regulation of skeletal muscle, but conflicting results make it difficult to define the...

Authors: Gyrd O. Gjevestad, Kirsten B. Holven, Amanda Rundblad, Arnar Flatberg, Mari Myhrstad, Karina Karlsen, Shivaprakash J. Mutt, Karl-Heinz Herzig, Inger Ottestad and Stine M. Ulven

The role of PPARγ in childhood obesity-induced fractures

Globally, obesity is on the rise with ~ 30% of the world’s population now obese, and childhood obesity is following similar trends. Childhood obesity has been associated with numerous chronic conditions, inclu...

Authors: Matthew R. McCann and Anusha Ratneswaran

Endorsing the STrengthening the Reporting of Observational Studies in Epidemiology-nutritional epidemiology (STROBE-nut) statement at Genes & Nutrition

Authors: Dana Hawwash and Carl Lachat

Estrogen biosynthesis in cultured skeletal muscle cells (L6) induced by amino acids

Previous investigations have indicated upregulation of gene expression in cellular pathways related to the biosynthesis of steroids in response to amino acids (AA) in skeletal muscle cells. This suggests AA as...

Authors: Britt-Marie Iresjö, Andreas Landin, Claes Ohlsson and Kent Lundholm

Biomarkers of cereal food intake

Cereal foods are major contributors to the daily energy, protein, and dietary fiber intake all over the world. The role of cereals in human health is dependent on whether they are consumed as refined or whole ...

Authors: Rikard Landberg, Kati Hanhineva, Kieran Tuohy, Mar Garcia-Aloy, Izabela Biskup, Rafael Llorach, Xiaofei Yin, Lorraine Brennan and Marjukka Kolehmainen

Logical modelling reveals the PDC-PDK interaction as the regulatory switch driving metabolic flexibility at the cellular level

Metabolic flexibility is the ability of an organism to switch between substrates for energy metabolism, in response to the changing nutritional state and needs of the organism. On the cellular level, metabolic...

Authors: Samar HK Tareen, Martina Kutmon, Ilja CW Arts, Theo M de Kok, Chris T Evelo and Michiel E Adriaens

Evidence for the association between FTO gene variants and vitamin B12 concentrations in an Asian Indian population

Low vitamin B12 concentrations have been associated with major clinical outcomes, including adiposity, in Indian populations. The Fat mass and obesity-associated gene (FTO) is an established obesity-susceptibilit...

Authors: Shelini Surendran, Ramamoorthy Jayashri, Lauren Drysdale, Dhanasekaran Bodhini, Nagarajan Lakshmipriya, Coimbatore Subramanian Shanthi Rani, Vasudevan Sudha, Julie A. Lovegrove, Ranjit M. Anjana, Viswanathan Mohan, Venkatesan Radha, Rajendra Pradeepa and Karani S. Vimaleswaran

Metabolic regulation of lifespan from a C. elegans perspective

Decline of cellular functions especially cognitive is a major deficit that arises with age in humans. Harnessing the strengths of small and genetic tractable model systems has revealed key conserved regulatory...

Authors: Kathrine B. Dall and Nils J. Færgeman

Biomarkers of seaweed intake

Seaweeds are marine macroalgae, some of which are edible. They are rich in specific dietary fibers and also contain other characteristic biological constituents. Biological activities have been investigated ma...

Authors: Muyao Xi and Lars O. Dragsted

Mechanism of continuous high temperature affecting growth performance, meat quality, and muscle biochemical properties of finishing pigs

The mechanism of high ambient temperature affecting meat quality is not clear till now. This study investigated the effect of high ambient temperature on meat quality and nutrition metabolism in finishing pigs.

Authors: Xianyong Ma, Li Wang, Zibiao Shi, Wei Chen, Xuefen Yang, Youjun Hu, Chuntian Zheng and Zongyong Jiang

Dietary protein sources and tumoral overexpression of RhoA, VEGF-A and VEGFR2 genes among breast cancer patients

High protein intake may promote angiogenesis giving support to the development of metastasis according to the experimental data. However, nutritional epidemiologic evidence is inconsistent with metastasis. The...

Authors: Ali Shokri, Saeed Pirouzpanah, Mitra Foroutan-Ghaznavi, Vahid Montazeri, Ashraf Fakhrjou, Hojjatollah Nozad-Charoudeh and Gholamreza Tavoosidana

Identification of the 12q24 locus associated with fish intake frequency by genome-wide meta-analysis in Japanese populations

Japan is traditionally a country with one of the highest levels of fish consumption worldwide, although the westernization of the Japanese diet has resulted in the reduction of fish consumption. A recent meta-...

Authors: Maki Igarashi, Shun Nogawa, Kaoru Kawafune, Tsuyoshi Hachiya, Shoko Takahashi, Huijuan Jia, Kenji Saito and Hisanori Kato

Effect of gestational oily fish intake on the risk of allergy in children may be influenced by FADS1/2, ELOVL5 expression and DNA methylation

Evidence suggests that prenatal exposure to n-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease in children. LCPUFAs are produced from dietary precursors catalyzed by des...

Authors: Purevsuren Losol, Faisal I. Rezwan, Veeresh K. Patil, Carina Venter, Susan Ewart, Hongmei Zhang, S. Hasan Arshad, Wilfried Karmaus and John W. Holloway

Interaction between the amount of dietary protein and the environmental temperature on the expression of browning markers in adipose tissue of rats

A low-protein diet increases the expression and circulating concentration of FGF21. FGF21 stimulates the browning process of WAT by enhancing the expression of UCP1 coupled with an increase in PGC1α. Interesti...

Authors: Gabriela Alemán, Ana Laura Castro, Ana Vigil-Martínez, Ivan Torre-Villalvazo, Andrea Díaz-Villaseñor, Lilia G. Noriega, Isabel Medina-Vera, Guillermo Ordáz, Nimbe Torres and Armando R. Tovar