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  1. Content type: Research

    Liver is the crucial organ as a hub for metabolic reactions. p16(INK4a) is a well-established cyclin-dependent kinase (CDK) inhibitor that plays important role in the molecular pathways of senescence, which le...

    Authors: Xiyuan Zhang, Guanying Bianca Xu, Dan Zhou and Yuan-Xiang Pan

    Citation: Genes & Nutrition 2018 13:6

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  2. Content type: Research

    Variation in the fat mass and obesity-associated gene (FTO) has been associated with susceptibility to obesity, but the association appears to be modified by diet. We investigated whether dietary protein intake m...

    Authors: David C. Merritt, Joseph Jamnik and Ahmed El-Sohemy

    Citation: Genes & Nutrition 2018 13:4

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  3. Content type: Review

    Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessme...

    Authors: Giulia Praticò, Qian Gao, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Sri Harsha Pedapati, Lydia A. Afman, David S. Wishart, Rosa Vázquez-Fresno, Cristina Andres Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens and Lars O. Dragsted

    Citation: Genes & Nutrition 2018 13:3

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  4. Content type: Review

    Vitamin B12 is an essential micronutrient in humans needed for health maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and genetic factors. Evidence for the genetic basis of vit...

    Authors: S. Surendran, A. Adaikalakoteswari, P. Saravanan, I. A. Shatwaan, J. A. Lovegrove and K. S. Vimaleswaran

    Citation: Genes & Nutrition 2018 13:2

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  5. Content type: Research

    Genetic polymorphisms of antioxidant enzymes CAT, GPX, and SOD are involved in the etiology of obesity and its principal comorbidities. The aim of the present study was to analyze the effect of aforementioned ...

    Authors: César Hernández-Guerrero, Alicia Parra-Carriedo, Diana Ruiz-de-Santiago, Oscar Galicia-Castillo, Mario Buenrostro-Jáuregui and Carmen Díaz-Gutiérrez

    Citation: Genes & Nutrition 2018 13:1

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  6. Content type: Review

    Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical ap...

    Authors: Keith A. Grimaldi, Ben van Ommen, Jose M. Ordovas, Laurence D. Parnell, John C. Mathers, Igor Bendik, Lorraine Brennan, Carlos Celis-Morales, Elisa Cirillo, Hannelore Daniel, Brenda de Kok, Ahmed El-Sohemy, Susan J. Fairweather-Tait, Rosalind Fallaize, Michael Fenech, Lynnette R. Ferguson…

    Citation: Genes & Nutrition 2017 12:35

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  7. Content type: Review

    Biomarkers are an efficient means to examine intakes or exposures and their biological effects and to assess system susceptibility. Aided by novel profiling technologies, the biomarker research field is underg...

    Authors: Qian Gao, Giulia Praticò, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Lydia A. Afman, David S. Wishart, Cristina Andres-Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens and Lars O. Dragsted

    Citation: Genes & Nutrition 2017 12:34

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  8. Content type: Research

    The inverse relationship between exercise capacity and its variation over time and both cardiovascular and all-cause mortality suggests the existence of an etiological nexus between cardiometabolic diseases an...

    Authors: Natalia Gomes Gonçalves, Stephanie Heffer Cavaletti, Carlos Augusto Pasqualucci, Milton Arruda Martins and Chin Jia Lin

    Citation: Genes & Nutrition 2017 12:33

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  9. Content type: Research

    A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the “PhenFlex test” (PFT). Recently, it has been shown tha...

    Authors: T. J. van den Broek, G. C. M. Bakker, C. M. Rubingh, S. Bijlsma, J. H. M. Stroeve, B. van Ommen, M. J. van Erk and S. Wopereis

    Citation: Genes & Nutrition 2017 12:32

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  10. Content type: Research

    We investigated whether the long-term consumption of a symbiotic formulation with Lactobacillus fermentum (probiotic) and β-glucan from cauliflower mushroom (prebiotic) would delay the progression of post-menopau...

    Authors: Seong-Yeop Jeong, Suna Kang, Cao Shi Hua, Zhang Ting and Sunmin Park

    Citation: Genes & Nutrition 2017 12:31

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  11. Content type: Research

    The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in SLC30A8 is associated with an ...

    Authors: Isabel Drake, George Hindy, Ulrika Ericson and Marju Orho-Melander

    Citation: Genes & Nutrition 2017 12:30

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  12. Content type: Review

    A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with c...

    Authors: Joseph J. Castillo, Robert A. Orlando and William S. Garver

    Citation: Genes & Nutrition 2017 12:29

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  13. Content type: Research

    Obesity is a complex pathology associated with dysbiosis, metabolic alterations, and low-grade chronic inflammation promoted by immune cells, infiltrating and populating the adipose tissue. Probiotic supplemen...

    Authors: Marianna Roselli, Chiara Devirgiliis, Paola Zinno, Barbara Guantario, Alberto Finamore, Rita Rami and Giuditta Perozzi

    Citation: Genes & Nutrition 2017 12:25

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  14. Content type: Review

    Obesity, a major cause of death and disability, is increasing worldwide. Obesity is characterized by a chronic, low-grade inflammatory state which is suggested to play a critical role in the development of obe...

    Authors: Vibeke H. Telle-Hansen, Jacob J. Christensen, Stine M. Ulven and Kirsten B. Holven

    Citation: Genes & Nutrition 2017 12:26

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  15. Content type: Review

    Dietary supplementation of essential amino acids (EAAs) has been shown to promote healthspan. EAAs regulate, in fact, glucose and lipid metabolism and energy balance, increase mitochondrial biogenesis, and mai...

    Authors: Francesco Bifari, Chiara Ruocco, Ilaria Decimo, Guido Fumagalli, Alessandra Valerio and Enzo Nisoli

    Citation: Genes & Nutrition 2017 12:27

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  16. Content type: Research

    During evolution, humans colonized different ecological niches and adopted a variety of subsistence strategies that gave rise to diverse selective pressures acting across the genome. Environmentally induced se...

    Authors: Silvia Parolo, Sébastien Lacroix, Jim Kaput and Marie-Pier Scott-Boyer

    Citation: Genes & Nutrition 2017 12:28

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  17. Content type: Commentary

    In the dietary and health research area, biomarkers are extensively used for multiple purposes. These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects...

    Authors: Lars O. Dragsted, Qian Gao, Giulia Praticò, Claudine Manach, David S. Wishart, Augustin Scalbert and Edith J. M. Feskens

    Citation: Genes & Nutrition 2017 12:24

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  18. Content type: Review

    In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in mai...

    Authors: Giuseppe Iacomino and Alfonso Siani

    Citation: Genes & Nutrition 2017 12:23

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  19. Content type: Research

    Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administer...

    Authors: Isabelle R. Miousse, Rupak Pathak, Sarita Garg, Charles M. Skinner, Stepan Melnyk, Oleksandra Pavliv, Howard Hendrickson, Reid D. Landes, Annie Lumen, Alan J. Tackett, Nicolaas E.P. Deutz, Martin Hauer-Jensen and Igor Koturbash

    Citation: Genes & Nutrition 2017 12:22

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  20. Content type: Research

    A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultane...

    Authors: Suzan Wopereis, Johanna H. M. Stroeve, Annette Stafleu, Gertruud C. M. Bakker, Jacobus Burggraaf, Marjan J. van Erk, Linette Pellis, Ruud Boessen, Alwine A. F. Kardinaal and Ben van Ommen

    Citation: Genes & Nutrition 2017 12:21

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  21. Content type: Research

    The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of...

    Authors: Yosra Ben Halima, Rym Kefi, Marco Sazzini, Cristina Giuliani, Sara De Fanti, Chokri Nouali, Majdi Nagara, Giacomo Mengozzi, Sahar Elouej, Abdelmajid Abid, Henda Jamoussi, Lotfi Chouchane, Giovanni Romeo, Sonia Abdelhak and Donata Luiselli

    Citation: Genes & Nutrition 2017 12:20

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  22. Content type: Research

    A polymorphism in a gene may exert its effects on multiple phenotypes. The aim of this study is to explore the association of 10 metabolic syndrome candidate genes with excess weight and adiposity and evaluate...

    Authors: Angélica María Muñoz, Claudia María Velásquez, Gloria María Agudelo, Rosa Magdalena Uscátegui, Alejandro Estrada, Fredy Alonso Patiño, Beatriz Elena Parra, María Victoria Parra and Gabriel Bedoya

    Citation: Genes & Nutrition 2017 12:19

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