Fig. 6
From: The interactions of flavonoids within neuronal signalling pathways
The structure of MEK inhibitor PD98059 and the PI3K inhibitors, LY294002, have close structural homology to that of flavonoids. LY294002 and quercetin both fit into the ATP binding pocket of the PI3K, inhibiting its activity. It appears that the number and substitution of hydroxyl groups on the flavonoid B-ring and the degree of un-saturation of the C2–C3 bond are important determinants of their activity. Such inhibitory actions have been proposed as potential mechanisms by which flavonoids act to modulate neuronal function