Table 1 Genes regulated by trans-10, cis-12 CLA involved in lipid and glucose metabolism
Gene title | Gene symbol | Entrez gene | Fold change |
|---|---|---|---|
Lipid transport/storage | |||
Apolipoprotein A-IV | APOA4 | 337 | 6.98 |
Fatty acid binding protein 6, ileal (gastrotropin) | FABP6 | 2172 | 2.94 |
Fatty acid binding protein 1, liver | FABP1 | 2168 | 2.04 |
Low density lipoprotein receptor (familial hypercholesterolemia) | LDLR | 3948 | 1.72 |
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 | APOBEC1 | 9582 | −1.76 |
Solute carrier family 27 (fatty acid transporter), member 3 | SLC27A3 | 11000 | −1.76 |
Apolipoprotein D | APOD | 347 | −3.32 |
ATP-binding cassette, sub-family A (ABC1), member 1 | ABCA1 | 19 | −4.63 |
Lipolysis | |||
Monoglyceride lipase | MGLL | 11343 | 2.22 |
Lipase, endothelial | LIPG | 9388 | 1.65 |
Lipase, hepatic | LIPC | 390 | −2.09 |
Fatty acid metabolism | |||
Stearoyl-CoA desaturase (delta-9-desaturase) | SCD | 6319 | 2.14 |
Acyl-CoA synthetase long-chain family member 1 | ACSL1 | 2180 | 2.00 |
Acyl-CoA synthetase long-chain family member 4 | ACSL4 | 2182 | 1.65 |
Thioesterase, adipose associated | THEA | 26027 | 1.65 |
Brain acyl-CoA hydrolase | BACH | 11332 | −1.66 |
Stearoyl-CoA desaturase 5 | SCD5 | 79966 | −2.77 |
LAG1 longevity assurance homologue 6 (S. cerevisiae) | LASS6 | 253782 | −1.67 |
Fatty acid β-oxidation | |||
Carnitine palmitoyltransferase 1A (liver) | CPT1A | 1374 | 2.81 |
Steroid metabolism | |||
Hydroxysteroid (17-beta) dehydrogenase 2 | HSD17B2 | 3294 | 3.26 |
Sulfotransferase family, cytosolic, 1B, member 1 | SULT1B1 | 27284 | 3.06 |
Cytochrome P450, family 3, subfamily A, polypeptide 5 | CYP3A5 | 1577 | 2.07 |
Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | SULT1A1 | 6817 | 1.97 |
Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 | SULT1A2 | 6799 | 1.88 |
Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 | SULT1A3 | 6818 | 1.83 |
Dehydrogenase/reductase (SDR family) member 9 | DHRS9 | 10170 | 1.80 |
Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | LSS | 4047 | 1.73 |
Steroid sulfatase (microsomal), arylsulfatase C, isozyme S | STS | 412 | −1.95 |
Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | SULT2A1 | 6822 | −1.98 |
UDP glycosyltransferase 2 family, polypeptide B17 | UGT2B17 | 7367 | −4.87 |
Cholesterol biosynthesis | |||
Protein kinase, AMP-activated, gamma 2 non-catalytic subunit | PRKAG2 | 51322 | 2.33 |
Mevalonate (diphospho) decarboxylase | MVD | 4597 | 1.72 |
7-Dehydrocholesterol reductase | DHCR7 | 1717 | 1.66 |
Membrane lipid metabolism | |||
Annexin A1 | ANXA1 | 301 | 2.78 |
Lysophosphatidylglycerol acyltransferase 1 | LPGAT1 | 9926 | 2.37 |
Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | SMPD3 | 55512 | 2.25 |
Phospholipase D1, phosphatidylcholine-specific | PLD1 | 2822 | 1.81 |
Sphingosine-1-phosphate lyase 1 | SGPL1 | 8879 | 1.79 |
Phospholipase A2-activating protein | PLAA | 9373 | 1.77 |
Hypothetical protein MGC26963 | MGC26963 | 166929 | 1.66 |
Selenoprotein I | SELI | 85465 | 1.64 |
Glycerol-3-phosphate acyltransferase, mitochondrial | GPAM | 57678 | −1.63 |
Phosphatidic acid phosphatase type 2B | PPAP2B | 8613 | −1.78 |
GM2 ganglioside activator | GM2A | 2760 | −1.83 |
Adipocyte secretory products | |||
Adiponutrin | ADPN | 80339 | 1.66 |
Lipin 1 | LPIN1 | 23175 | 2.08 |
Adipose differentiation- related protein | ADFP | 123 | 1.75 |
Glycolysis and gluconeogenesis | |||
Phosphofructokinase, platelet | PFKP | 5214 | 1.69 |
Fructose-1,6-bisphosphatase 1 | FBP1 | 2203 | 2.00 |
Aldolase B, fructose-bisphosphate | ALDOB | 229 | 3.67 |
Hexokinase 2 | HK2 | 3099 | 1.84 |
Citrate cycle | |||
ATP citrate lyase | ACLY | 47 | 1.65 |
Isocitrate dehydrogenase 2 (NADP+), mitochondrial | IDH2 | 3418 | −1.66 |
Phosphoenolpyruvate carboxykinase 1 (soluble) | PCK1 | 5105 | 3.33 |
Transcription factors | |||
Nuclear receptor subfamily 1, group H, member 4 (farnesoid X receptor) | NR1H4 | 9971 | 5.25 |
Peroxisome proliferative activated receptor, gamma | PPARG | 5468 | 2.82 |
Hepatocyte nuclear factor 4, alpha | HNF4A | 3172 | 2.23 |
Nuclear receptor subfamily 1, group I, member 2 (Pregnane X receptor) | NR1I2 | 8856 | 1.86 |
Peroxisome proliferative activated receptor, delta | PPARD | 5467 | 1.79 |
Nuclear receptor subfamily 2, group F, member 2 (COUP-transcription factor 2) | NR2F2 | 7026 | −3.08 |