Impact of diet on adult hippocampal neurogenesis

Genes & Nutrition

Table 1 Modulation of adult hippocampal neurogenesis (AHN) by diet

Diet	Study models	Effect on AHN	References
Caloric restriction/dietary restriction	Rat	Increased survival	[60]
Caloric restriction/dietary restriction	Mouse	Increased survival	[62], [61], [54], [8]
Omega 3 fatty acids	Rat	Increased (DHA)	[46]
Flavonoids	Rat, chronically stressed	Increased proliferation	[3]
Blueberry	Rat	Increased proliferation	[12]
Curcumin low concentrations	Mouse	Increased proliferation	[53]
Retinoic acid excess	Mouse	Decreased proliferation	[16]
Vitamin A deficiency	Rat	Decreased proliferation (rescued with retinoic acid)	[9]
Thiamine deficiency	Mouse	Decreased proliferation/survival	[128]
Zinc deficiency	Rat male	Decreased proliferation/survival	[14]
Folate deficiency	Mouse	Inhibited proliferation	[56]
Increased homocysteine	Mouse	Inhibited proliferation	[93] [57]
High fat	Male rat	Decreased proliferation	[67]
High fat	Female rat	No change	[67]
Soft diet	Rat	Decreased proliferation	[4]
Caffeine
At physiologically relevant doses	Mouse	Decreased proliferation	[121]
At supraphysiological doses	Mouse	Increased proliferation/decreased survival	[121]
Low doses, chronically	Rat	Decreased proliferation	[36]
Ethanol	Rat	Decreased proliferation	[84], [37]
Ethanol	Mouse	Decreased proliferation	[103]

ISSN: 1865-3499