Table 3 Gene expression changes 12 h post ethanol bolus and the effects of SAMe on these changes

CYP1a1

7.84

8.11

Cytochrome p450 1a1

CYP17A

4.56

2.71

Cytochrome p450 17A1

Cycl 1

4.06

15.67

Chemokine legand 1

Gadd45b

4.06

3.2

Growth arrest and DNA damage 45b

CYP7a1

3.63

nc

Cytochrome p450 7a 1

Gsta2

3.01

−2

Glutathionine S-transferase a2

Garld45g

2.87

nc

Growth arrest and DNA damage 45q

Hmoxl

2.51

nc

Homogenase 1

Fabp4

1.58

nc

Fatty acid binding protein 4

Mknk2

1.82

nc

MAP kinase-threonine kinase 2

Adipor2

1.67

2.13

Adiponectin receptor 2

Cth

−1.88

2.77

Cystathionase

Lepr

−2.71

9.58

Leptin receptor

Jak3

nc

3.03

Janus kinase 3

Adhi

nc

2.81

Alcohol dehydrogenase 1

CYP4a1

nc

2.35

Cytochrome p450 4a1

Stat3

nc

2.35

Signal transdura activator transcription 3

Jun b

nc

2.1

Jun B oncogene

Timp2

nc

1.74

Tissue inhibitor metalloproteinase 2

HAT1

nc

−1.83

Histone aminotransferase 1

Aldh5a1

nc

−1.87

Aldehyde dehydrogenase 5

FOXa2

nc

−2.06

Forehead box AZ

Hdac2

nc

−2.06

Histone deacetylase 2

Bhmt

nc

−2.27

Betaine homocysteine methyltransferase

Ubd

nc

2.41

Ubiquitin D

Aldh1b1

nc

2.41

Aldehyde dehydrogenase 1