Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein −493 G/T polymorphism and the usual diet in women

Wolff, Estelle; Vergnes, Marie-France; Defoort, Catherine; Planells, Richard; Portugal, Henri; Nicolay, Alain; Lairon, Denis

doi:10.1007/s12263-010-0174-x

Table 4 Fasting biochemical parameters under a Western-type diet (WD) at entry and after a 3-mo low-saturated fat, low-cholesterol/Mediterranean-type diet (LFLCD) according to MTTP−493G/T polymorphism

From: Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein −493 G/T polymorphism and the usual diet in women

69 women	G/G + G/T n = 60	T/T n = 9	P value^a
Cholestanol^b
Entry	133.0 ± 7.4	199.0 ± 30.0	0.002
Month 3	143.3 ± 7.8	173.5 ± 20.1	ns
Mean change	9.98 ± 6.14	−25.59 ± 24.21	0.045
Sitosterol^b
Entry	109.0 ± 9.9	261.1 ± 104.7	0.002
Month 3	133.9 ± 11.9	215.7 ± 80.0	0.081
Mean change	23.67 ± 11.08	−45.37 ± 43.37	0.035
Desmosterol^b
Entry	110.1 ± 4.5	109.2 ± 4.2	ns
Month 3	107.7 ± 4.4	102.5 ± 6.2	ns
Mean change	−3.81 ± 4.00	−6.64 ± 6.86	ns
Lathosterol^c
Entry	147.6 ± 9.1	188.7 ± 21.8	0.101
Month 3	144.8 ± 10.7	195.5 ± 22.0	0.032
Mean change	−4.42 ± 8.89	6.77 ± 12.80	ns
Cholesterol (mmol/l)
Entry	6.63 ± 0.12	7.37 ± 0.22	0.023
Month 3	6.35 ± 0.12*	6.70 ± 0.21*	ns
Mean change	−0.277 ± 0.096	−0.663 ± 0.267	ns
HDL cholesterol (mmol/l)
Entry	1.66 ± 0.06	1.65 ± 0.19	ns
Month 3	1.66 ± 0.08	1.63 ± 0.23	ns
Mean change	−0.004 ± 0.046	−0.013 ± 0.093	ns
LDL cholesterol (mmol/l)
Entry	4.25 ± 0.13	4.81 ± 0.22	0.107
Month 3	4.08 ± 0.10	4.41 ± 0.18*	0.130
Mean change	−0.177 ± 0.104	−0.403 ± 0.164	ns
TRL cholesterol (mmol/l)
Entry	0.95 ± 0.08	1.37 ± 0.31	0.091
Month 3	0.93 ± 0.08	0.88 ± 0.17	ns
Mean change	−0.017 ± 0.078	−0.493 ± 0.294	0.050
ApoB-cholesterol (mmol/l)
Entry	5.16 ± 0.16	6.07 ± 0.47	0.056
Month 3	5.07 ± 1.08	5.42 ± 0.98	ns
Mean change	−0.14 ± 0.13	−0.90 ± 0.40	0.049
Triglycerides (mmol/l)
Entry	1.592 ± 0.088	1.623 ± 0.321	ns
Month 3	1.453 ± 0.081	1.199 ± 0.173	ns
Mean change	−0.137 ± 0.064	−0.424 ± 0.370	ns
TRL TG (mmol/l)
Entry	0.86 ± 0.08	0.85 ± 0.17	ns
Month 3	0.81 ± 0.07	0.78 ± 0.18	ns
Mean change	−0.023 ± 0.067	−0.071 ± 0.094	ns
ApoB (mmol/l)
Entry	1.27 ± 0.03	1.21 ± 0.09	ns
Month 3	1.21 ± 0.03*	1.21 ± 0.10	ns
Mean change	−0.065 ± 0.026	−0.041 ± 0.047	ns
Insulin (μU/ml)
Entry	10.22 ± 0.87	8.78 ± 1.66	ns
Month 3	8.33 ± 0.56*	7.41 ± 2.02	ns
Mean change	−2.04 ± 0.54	−1.21 ± 1.14	ns

Values are mean ± SEM. Mean changes are calculated as 3-mo value minus entry value. ApoB-cholesterol is the calculated sum of apoB-containing LDL and TRL-cholesterol levels
^aComparison between genotypes at entry with Western-type diet (WD) and in their response to low-saturated fat, low-cholesterol/Mediterranean-type diet (LFLCD) tested with general linear models and adjusted for age, menopausal status and BMI. ns non-significant (P ≥ 0.05)
^b10²mmol/mol cholesterol
* P < 0.05 for comparison between entry and 3-mo (calculated by Student’s t paired test for G/G and G/T and by Wilcoxon test for T/T)

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ISSN: 1865-3499

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