Fig. 5

Involvement of naturally occurring chalcone derivatives in regulation of the cell cycle. Chalcone derivatives may induce ATM (chalcone 2), which in turn phosphorylates p53, thus decreasing p53/MDM2 interaction. However, ATM augmentation subsequently leads to phosphorylation of Chk1 and Chk2 and reduces the level of Cdc25c resulting in G2/M arrest. By activating inhibitors of Cdks (p21 and p27), chalcone derivatives may participate in cell cycle arrest in either G1 or G2/M phase (chalcones 2, 10, 18, 23). Arrows represent induction/activation and blunt-ended lines represent repression/inactivation. Abbreviations: Cdk cyclin-dependent kinase, ATM ataxia telangiectasia mutated, Chk checkpoint homolog serine/threonine-protein kinase, Cdc25c cell division cycle 25 homolog C. This figure was generated with ScienceSlides software